BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUTS2 autism susceptibility candidate 2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EHD3 EH-domain containing 3
ENO2 enolase 2 (gamma, neuronal)
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IRX5 iroquois homeobox 5
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
LIMCH1 LIM and calponin homology domains 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NKX3-1 NK3 homeobox 1
PENK proenkephalin
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIEZO1 piezo-type mechanosensitive ion channel component 1
PSAP prosaposin
QPCT glutaminyl-peptide cyclotransferase
SAMD4A sterile alpha motif domain containing 4A
SLC48A1 solute carrier family 48 (heme transporter), member 1
SPP1 secreted phosphoprotein 1
SULF1 sulfatase 1
TOX3 TOX high mobility group box family member 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2

decreased expression

Symbol Name
ANGPT1 angiopoietin 1
ARMCX1 armadillo repeat containing, X-linked 1
BTG2 BTG family, member 2
DAPK1 death-associated protein kinase 1
DLK1 delta-like 1 homolog (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM107A family with sequence similarity 107, member A
FBXL12 F-box and leucine-rich repeat protein 12
GAS1 growth arrest-specific 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA5 homeobox A5
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC17 leucine rich repeat containing 17
MEIS1 Meis homeobox 1
PLAGL1 pleiomorphic adenoma gene-like 1
POSTN periostin, osteoblast specific factor
PSPH phosphoserine phosphatase
PTGER4 prostaglandin E receptor 4 (subtype EP4)
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLPI secretory leukocyte peptidase inhibitor
SRPX sushi-repeat containing protein, X-linked
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)