BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
CA12 carbonic anhydrase XII
CD163 CD163 molecule
COMT catechol-O-methyltransferase
CPA3 carboxypeptidase A3 (mast cell)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFA5 defensin, alpha 5, Paneth cell-specific
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GOLM1 golgi membrane protein 1
GPX2 glutathione peroxidase 2
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IRS2 insulin receptor substrate 2
LTF lactotransferrin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
NQO1 NAD(P)H dehydrogenase, quinone 1
PCDH9 protocadherin 9
PDLIM5 PDZ and LIM domain 5
PIR pirin (iron-binding nuclear protein)
PNKP polynucleotide kinase 3'-phosphatase
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TP53I3 tumor protein p53 inducible protein 3
TRBC1 T cell receptor beta constant 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSPO translocator protein (18kDa)
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADGRL2 adhesion G protein-coupled receptor L2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMIGO2 adhesion molecule with Ig-like domain 2
ARMCX1 armadillo repeat containing, X-linked 1
C7 complement component 7
CCNA2 cyclin A2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
DPP4 dipeptidyl-peptidase 4
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FHL1 four and a half LIM domains 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNAS GNAS complex locus
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
IRF8 interferon regulatory factor 8
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
LUM lumican
MCM7 minichromosome maintenance complex component 7
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTGIS prostaglandin I2 (prostacyclin) synthase
RBBP8 retinoblastoma binding protein 8
RFTN1 raftlin, lipid raft linker 1
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
SCGB2A1 secretoglobin, family 2A, member 1
SPON1 spondin 1, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM2 tropomyosin 2 (beta)
TRIB3 tribbles pseudokinase 3
TSPAN8 tetraspanin 8
XBP1 X-box binding protein 1
ZNF512B zinc finger protein 512B