BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AEBP1 AE binding protein 1
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C2CD2 C2 calcium-dependent domain containing 2
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CD163 CD163 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CLEC7A C-type lectin domain family 7, member A
CXCL11 chemokine (C-X-C motif) ligand 11
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EML1 echinoderm microtubule associated protein like 1
EPAS1 endothelial PAS domain protein 1
EVI2A ecotropic viral integration site 2A
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GAS6 growth arrest-specific 6
GATA6 GATA binding protein 6
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGHM immunoglobulin heavy constant mu
INSM1 insulinoma-associated 1
JUN jun proto-oncogene
KLHL24 kelch-like family member 24
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAST4 microtubule associated serine/threonine kinase family member 4
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
NDRG1 N-myc downstream regulated 1
NEB nebulin
NRCAM neuronal cell adhesion molecule
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDPN podoplanin
PDZD2 PDZ domain containing 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAU plasminogen activator, urokinase
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLVAP plasmalemma vesicle associated protein
PRKCI protein kinase C, iota
PRUNE2 prune homolog 2 (Drosophila)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SFRP4 secreted frizzled-related protein 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SPATA7 spermatogenesis associated 7
ST18 suppression of tumorigenicity 18, zinc finger
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STON1 stonin 1
THBS1 thrombospondin 1
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TREM2 triggering receptor expressed on myeloid cells 2
TRIM36 tripartite motif containing 36
TWIST1 twist family bHLH transcription factor 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTN1 actinin, alpha 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
AMD1 adenosylmethionine decarboxylase 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARF4 ADP-ribosylation factor 4
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BASP1 brain abundant, membrane attached signal protein 1
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
CLU clusterin
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COL9A3 collagen, type IX, alpha 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CRLF1 cytokine receptor-like factor 1
CST3 cystatin C
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EIF4E eukaryotic translation initiation factor 4E
ERLIN1 ER lipid raft associated 1
FUCA1 fucosidase, alpha-L- 1, tissue
GCH1 GTP cyclohydrolase 1
GMDS GDP-mannose 4,6-dehydratase
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTM3 glutathione S-transferase mu 3 (brain)
HN1 hematological and neurological expressed 1
IER3 immediate early response 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
MAMLD1 mastermind-like domain containing 1
MARCKSL1 MARCKS-like 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MPC1 mitochondrial pyruvate carrier 1
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PDHB pyruvate dehydrogenase (lipoamide) beta
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SEC23IP SEC23 interacting protein
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SIAH2 siah E3 ubiquitin protein ligase 2
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SORBS2 sorbin and SH3 domain containing 2
SORD sorbitol dehydrogenase
SRSF6 serine/arginine-rich splicing factor 6
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TEX10 testis expressed 10
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM2 translocation associated membrane protein 2
TRAPPC4 trafficking protein particle complex 4
UBE2N ubiquitin-conjugating enzyme E2N