BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
ATF3 activating transcription factor 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CD163 CD163 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
FLT1 fms-related tyrosine kinase 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP12 matrix metallopeptidase 12
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A1 nuclear receptor subfamily 4, group A, member 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCDH9 protocadherin 9
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PER1 period circadian clock 1
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRO protein tyrosine phosphatase, receptor type, O
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RPL38 ribosomal protein L38
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TIMP3 TIMP metallopeptidase inhibitor 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
APOD apolipoprotein D
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CD44 CD44 molecule (Indian blood group)
COL13A1 collagen, type XIII, alpha 1
DUSP6 dual specificity phosphatase 6
FAM129A family with sequence similarity 129, member A
FGF13 fibroblast growth factor 13
FLRT2 fibronectin leucine rich transmembrane protein 2
G0S2 G0/G1 switch 2
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
JADE2 jade family PHD finger 2
KRT15 keratin 15, type I
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
MGP matrix Gla protein
MSH6 mutS homolog 6
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDE4B phosphodiesterase 4B, cAMP-specific
PLA2G16 phospholipase A2, group XVI
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
RRAGA Ras-related GTP binding A
SACS sacsin molecular chaperone
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TRAPPC3 trafficking protein particle complex 3
TRIM14 tripartite motif containing 14
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
UGCG UDP-glucose ceramide glucosyltransferase
VAV3 vav 3 guanine nucleotide exchange factor
ZBTB18 zinc finger and BTB domain containing 18