BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANGPTL4 angiopoietin-like 4
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAMBI BMP and activin membrane-bound inhibitor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA1 chloride channel accessory 1
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
CTH cystathionine gamma-lyase
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGR1 early growth response 1
FABP4 fatty acid binding protein 4, adipocyte
FOLR1 folate receptor 1 (adult)
FOXO1 forkhead box O1
GOLGA8A golgin A8 family, member A
GUCA2A guanylate cyclase activator 2A (guanylin)
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BG histone cluster 1, H2bg
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIF14 kinesin family member 14
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LOC100272216 uncharacterized LOC100272216
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MAST4 microtubule associated serine/threonine kinase family member 4
MFSD10 major facilitator superfamily domain containing 10
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSX1 msh homeobox 1
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRL platelet-derived growth factor receptor-like
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS16 regulator of G-protein signaling 16
RNMT RNA (guanine-7-) methyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERTAD2 SERTA domain containing 2
SFRP4 secreted frizzled-related protein 4
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOCS2 suppressor of cytokine signaling 2
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STC1 stanniocalcin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2A transformer 2 alpha homolog (Drosophila)
TSPYL2 TSPY-like 2
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZG16 zymogen granule protein 16
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ACAD8 acyl-CoA dehydrogenase family, member 8
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
AREG amphiregulin
ARF4 ADP-ribosylation factor 4
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ATF1 activating transcription factor 1
AURKA aurora kinase A
B3GNT1
BAG5 BCL2-associated athanogene 5
BANK1 B-cell scaffold protein with ankyrin repeats 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
C12ORF29 chromosome 12 open reading frame 29
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTNND1 catenin (cadherin-associated protein), delta 1
DAPK1 death-associated protein kinase 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DICER1 dicer 1, ribonuclease type III
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FEN1 flap structure-specific endonuclease 1
FLG filaggrin
GAS2L1 growth arrest-specific 2 like 1
GPX1 glutathione peroxidase 1
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IPO5 importin 5
KDM5D lysine (K)-specific demethylase 5D
KIAA0391 KIAA0391
KRT1 keratin 1, type II
KRT10 keratin 10, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGST2 microsomal glutathione S-transferase 2
MSH6 mutS homolog 6
MTCL1 microtubule crosslinking factor 1
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOTCH2 notch 2
NPTX2 neuronal pentraxin II
NPY neuropeptide Y
NSF N-ethylmaleimide-sensitive factor
PAIP1 poly(A) binding protein interacting protein 1
PCGF2 polycomb group ring finger 2
PDHB pyruvate dehydrogenase (lipoamide) beta
PDLIM5 PDZ and LIM domain 5
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
RANBP6 RAN binding protein 6
RIN2 Ras and Rab interactor 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGA Ras-related GTP binding A
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCEL sciellin
SCML1 sex comb on midleg-like 1 (Drosophila)
SEC23A Sec23 homolog A (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP1 secreted frizzled-related protein 1
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPTSSA serine palmitoyltransferase, small subunit A
SRP54 signal recognition particle 54kDa
SRSF6 serine/arginine-rich splicing factor 6
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THY1 Thy-1 cell surface antigen
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM251 transmembrane protein 251
TMEM43 transmembrane protein 43
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRAPPC4 trafficking protein particle complex 4
TRIM14 tripartite motif containing 14
UBE2N ubiquitin-conjugating enzyme E2N
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UMPS uridine monophosphate synthetase
UNC13B unc-13 homolog B (C. elegans)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VEZF1 vascular endothelial zinc finger 1
ZBTB18 zinc finger and BTB domain containing 18
ZNF185 zinc finger protein 185 (LIM domain)