BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACAN aggrecan
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMDHD2 amidohydrolase domain containing 2
APOD apolipoprotein D
ARG2 arginase 2
ARHGAP25 Rho GTPase activating protein 25
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD4 bromodomain containing 4
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCBL2 cysteine conjugate-beta lyase 2
CCL20 chemokine (C-C motif) ligand 20
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC10A C-type lectin domain family 10, member A
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
COL9A2 collagen, type IX, alpha 2
CPE carboxypeptidase E
CTSK cathepsin K
CTSZ cathepsin Z
CTTN cortactin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDR2 discoidin domain receptor tyrosine kinase 2
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EFS embryonal Fyn-associated substrate
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EMILIN1 elastin microfibril interfacer 1
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GMFG glia maturation factor, gamma
GPNMB glycoprotein (transmembrane) nmb
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL13RA2 interleukin 13 receptor, alpha 2
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6B lysine (K)-specific demethylase 6B
LCN2 lipocalin 2
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MFSD10 major facilitator superfamily domain containing 10
MMP9 matrix metallopeptidase 9
MYL9 myosin, light chain 9, regulatory
MZB1 marginal zone B and B1 cell-specific protein
NCAM1 neural cell adhesion molecule 1
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NXN nucleoredoxin
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGF placental growth factor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCN3A sodium channel, voltage gated, type III alpha subunit
SLC38A1 solute carrier family 38, member 1
SMTN smoothelin
SNAI2 snail family zinc finger 2
SNX7 sorting nexin 7
SRPX sushi-repeat containing protein, X-linked
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
STC2 stanniocalcin 2
TCF4 transcription factor 4
TIMP3 TIMP metallopeptidase inhibitor 3
TSC22D3 TSC22 domain family, member 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP7 A kinase (PRKA) anchor protein 7
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AQP3 aquaporin 3 (Gill blood group)
ARF3 ADP-ribosylation factor 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAMBI BMP and activin membrane-bound inhibitor
BDNF brain-derived neurotrophic factor
C8ORF4 chromosome 8 open reading frame 4
CAST calpastatin
CCL2 chemokine (C-C motif) ligand 2
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
CLU clusterin
COCH cochlin
CRIP1 cysteine-rich protein 1 (intestinal)
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA7 golgin A7
GRB14 growth factor receptor-bound protein 14
HIST3H2A histone cluster 3, H2a
HOPX HOP homeobox
HOXA5 homeobox A5
HOXB2 homeobox B2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IRS2 insulin receptor substrate 2
KIAA0391 KIAA0391
KRT7 keratin 7, type II
LBH limb bud and heart development
LEF1 lymphoid enhancer-binding factor 1
LIG1 ligase I, DNA, ATP-dependent
LMO2 LIM domain only 2 (rhombotin-like 1)
LY75 lymphocyte antigen 75
MED1 mediator complex subunit 1
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCKAP1L NCK-associated protein 1-like
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
OXTR oxytocin receptor
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDLIM5 PDZ and LIM domain 5
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA1A phospholipase A1 member A
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51C RAD51 paralog C
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RHCG Rh family, C glycoprotein
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
SACS sacsin molecular chaperone
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TMF1 TATA element modulatory factor 1
TMX4 thioredoxin-related transmembrane protein 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRIM22 tripartite motif containing 22
TRIM32 tripartite motif containing 32
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPK1B uroplakin 1B
URI1 URI1, prefoldin-like chaperone
VCAN versican
VEZF1 vascular endothelial zinc finger 1
WFDC2 WAP four-disulfide core domain 2
ZBTB18 zinc finger and BTB domain containing 18
ZNF185 zinc finger protein 185 (LIM domain)