BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

124 genes differentially expressed following the BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BGN biglycan
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG2 BTG family, member 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMP cartilage oligomeric matrix protein
CTSZ cathepsin Z
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOK5 docking protein 5
EGR1 early growth response 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAS6 growth arrest-specific 6
GLUL glutamate-ammonia ligase
GSE1 Gse1 coiled-coil protein
HEPH hephaestin
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KTN1 kinectin 1 (kinesin receptor)
LTBP2 latent transforming growth factor beta binding protein 2
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
SULF1 sulfatase 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
AMD1 adenosylmethionine decarboxylase 1
APMAP adipocyte plasma membrane associated protein
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
AURKA aurora kinase A
BMI1 BMI1 proto-oncogene, polycomb ring finger
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CCNG1 cyclin G1
CD58 CD58 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLIC4 chloride intracellular channel 4
COASY CoA synthase
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCT dopachrome tautomerase
DLD dihydrolipoamide dehydrogenase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUSP4 dual specificity phosphatase 4
ERBB3 erb-b2 receptor tyrosine kinase 3
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
EXOSC4 exosome component 4
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GNAS GNAS complex locus
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGA2 high mobility group AT-hook 2
IGSF3 immunoglobulin superfamily, member 3
INTS5 integrator complex subunit 5
ITGB1BP1 integrin beta 1 binding protein 1
JADE2 jade family PHD finger 2
LAMB1 laminin, beta 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LYPLA1 lysophospholipase I
MET MET proto-oncogene, receptor tyrosine kinase
MYCBP MYC binding protein
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPARG peroxisome proliferator-activated receptor gamma
PRPF4 pre-mRNA processing factor 4
PRSS23 protease, serine, 23
RAD23B RAD23 homolog B (S. cerevisiae)
SEC24A SEC24 family member A
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC25A46 solute carrier family 25, member 46
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TBC1D16 TBC1 domain family, member 16
TBC1D4 TBC1 domain family, member 4
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM9SF2 transmembrane 9 superfamily member 2
TMEM2 transmembrane protein 2
USP22 ubiquitin specific peptidase 22
VEZF1 vascular endothelial zinc finger 1