BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EDNRB endothelin receptor type B
EPHA3 EPH receptor A3
FADS1 fatty acid desaturase 1
FAM13A family with sequence similarity 13, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LRRC15 leucine rich repeat containing 15
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR1D2 nuclear receptor subfamily 1, group D, member 2
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AGR2 anterior gradient 2
ARMCX2 armadillo repeat containing, X-linked 2
ASRGL1 asparaginase like 1
BTBD3 BTB (POZ) domain containing 3
CA12 carbonic anhydrase XII
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CTSG cathepsin G
CTSH cathepsin H
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATA2 GATA binding protein 2
GLRX glutaredoxin (thioltransferase)
GPER1 G protein-coupled estrogen receptor 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAG1 jagged 1
LEF1 lymphoid enhancer-binding factor 1
MAOA monoamine oxidase A
MAP2K6 mitogen-activated protein kinase kinase 6
MLPH melanophilin
MYC v-myc avian myelocytomatosis viral oncogene homolog
OPN3 opsin 3
PEG10 paternally expressed 10
PLAC8 placenta-specific 8
PRKCD protein kinase C, delta
PTPRC protein tyrosine phosphatase, receptor type, C
RGS13 regulator of G-protein signaling 13
TNNC1 troponin C type 1 (slow)
XIST X inactive specific transcript (non-protein coding)