BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

242 genes differentially expressed following the BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AMDHD2 amidohydrolase domain containing 2
APRT adenine phosphoribosyltransferase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATMIN ATM interactor
BMP7 bone morphogenetic protein 7
CAPN2 calpain 2, (m/II) large subunit
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CCL5 chemokine (C-C motif) ligand 5
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L2 chitinase 3-like 2
COTL1 coactosin-like F-actin binding protein 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSA cathepsin A
CTSB cathepsin B
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IFI30 interferon, gamma-inducible protein 30
IRS2 insulin receptor substrate 2
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LAMP1 lysosomal-associated membrane protein 1
LAMP3 lysosomal-associated membrane protein 3
LMO4 LIM domain only 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP12 matrix metallopeptidase 12
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
OPN3 opsin 3
PCDH9 protocadherin 9
PGLS 6-phosphogluconolactonase
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PMP22 peripheral myelin protein 22
PRAF2 PRA1 domain family, member 2
PSAP prosaposin
RAP1GAP RAP1 GTPase activating protein
RAP2A RAP2A, member of RAS oncogene family
RBMS1 RNA binding motif, single stranded interacting protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMOX spermine oxidase
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SQSTM1 sequestosome 1
TBX3 T-box 3
TFE3 transcription factor binding to IGHM enhancer 3
TMEM147 transmembrane protein 147
TNPO1 transportin 1
TPP1 tripeptidyl peptidase I
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSPAN7 tetraspanin 7
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VGLL4 vestigial-like family member 4
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADCY1 adenylate cyclase 1 (brain)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
APOD apolipoprotein D
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX1 armadillo repeat containing, X-linked 1
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
C7 complement component 7
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNE2 cyclin E2
CD200 CD200 molecule
CD24 CD24 molecule
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A2 collagen, type I, alpha 2
CP ceruloplasmin (ferroxidase)
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
DST dystonin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H4C histone cluster 1, H4c
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MANSC1 MANSC domain containing 1
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MREG melanoregulin
MRPL16 mitochondrial ribosomal protein L16
MUC1 mucin 1, cell surface associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
OLFML3 olfactomedin-like 3
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLS1 plastin 1
PRSS23 protease, serine, 23
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAD51AP1 RAD51 associated protein 1
RBPMS RNA binding protein with multiple splicing
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCEA2 transcription elongation factor A (SII), 2
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TK1 thymidine kinase 1, soluble
TMSB15B thymosin beta 15B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
TXNDC9 thioredoxin domain containing 9
TXNIP thioredoxin interacting protein
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VAMP8 vesicle-associated membrane protein 8
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein