BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

204 genes differentially expressed following the BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AEBP1 AE binding protein 1
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CLEC7A C-type lectin domain family 7, member A
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CRABP1 cellular retinoic acid binding protein 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
EPAS1 endothelial PAS domain protein 1
EVI2A ecotropic viral integration site 2A
FSD1 fibronectin type III and SPRY domain containing 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
JUN jun proto-oncogene
KCNK3 potassium channel, two pore domain subfamily K, member 3
KLHL24 kelch-like family member 24
LRRC15 leucine rich repeat containing 15
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEB nebulin
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPC1 Niemann-Pick disease, type C1
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PDZD2 PDZ domain containing 2
PKP1 plakophilin 1
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PTPRC protein tyrosine phosphatase, receptor type, C
PTX3 pentraxin 3, long
RAB21 RAB21, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RSAD2 radical S-adenosyl methionine domain containing 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
TOX thymocyte selection-associated high mobility group box
TPSAB1 tryptase alpha/beta 1
TRDV3 T cell receptor delta variable 3
TRIM36 tripartite motif containing 36
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTN1 actinin, alpha 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMD1 adenosylmethionine decarboxylase 1
APOA2 apolipoprotein A-II
APOD apolipoprotein D
APOH apolipoprotein H (beta-2-glycoprotein I)
ARF4 ADP-ribosylation factor 4
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATXN1 ataxin 1
BCLAF1 BCL2-associated transcription factor 1
BMP4 bone morphogenetic protein 4
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLU clusterin
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COL9A3 collagen, type IX, alpha 3
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERLIN1 ER lipid raft associated 1
FAM198B family with sequence similarity 198, member B
FUCA1 fucosidase, alpha-L- 1, tissue
GALE UDP-galactose-4-epimerase
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GMDS GDP-mannose 4,6-dehydratase
GSPT1 G1 to S phase transition 1
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HN1 hematological and neurological expressed 1
IER3 immediate early response 3
IGFBP1 insulin-like growth factor binding protein 1
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
LASP1 LIM and SH3 protein 1
LGALS1 lectin, galactoside-binding, soluble, 1
LYZ lysozyme
MARCKSL1 MARCKS-like 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGP matrix Gla protein
MGST2 microsomal glutathione S-transferase 2
MPC1 mitochondrial pyruvate carrier 1
NNT nicotinamide nucleotide transhydrogenase
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP210 nucleoporin 210kDa
ORM1 orosomucoid 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PCP4 Purkinje cell protein 4
PCTP phosphatidylcholine transfer protein
PEBP1 phosphatidylethanolamine binding protein 1
PGM1 phosphoglucomutase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RELN reelin
RNASET2 ribonuclease T2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SORBS1 sorbin and SH3 domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRP54 signal recognition particle 54kDa
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
SRSF9 serine/arginine-rich splicing factor 9
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TF transferrin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TMEM47 transmembrane protein 47
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2N ubiquitin-conjugating enzyme E2N
WDR1 WD repeat domain 1