BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRYAB crystallin, alpha B
DDIT3 DNA-damage-inducible transcript 3
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
ENO1 enolase 1, (alpha)
FAM13A family with sequence similarity 13, member A
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GAGE3 G antigen 3
GATA3 GATA binding protein 3
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
OSER1 oxidative stress responsive serine-rich 1
PERP PERP, TP53 apoptosis effector
PIR pirin (iron-binding nuclear protein)
PLBD1 phospholipase B domain containing 1
PLVAP plasmalemma vesicle associated protein
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RHOB ras homolog family member B
RRAGD Ras-related GTP binding D
SERTAD2 SERTA domain containing 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TACC2 transforming, acidic coiled-coil containing protein 2
TMEM176B transmembrane protein 176B
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
ARHGAP29 Rho GTPase activating protein 29
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CDC20 cell division cycle 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTSC cathepsin C
DLD dihydrolipoamide dehydrogenase
DUSP6 dual specificity phosphatase 6
F3 coagulation factor III (thromboplastin, tissue factor)
FGFR3 fibroblast growth factor receptor 3
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
IGFBP4 insulin-like growth factor binding protein 4
ITM2A integral membrane protein 2A
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KIAA0485 uncharacterized LOC57235
LAMB1 laminin, beta 1
LEPR leptin receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLSCR4 phospholipid scramblase 4
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSAT1 phosphoserine aminotransferase 1
PTCH1 patched 1
RBM34 RNA binding motif protein 34
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
SACS sacsin molecular chaperone
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAD3 SMAD family member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
SSFA2 sperm specific antigen 2
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VCAN versican
WWTR1 WW domain containing transcription regulator 1
ZNF22 zinc finger protein 22