BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BGN biglycan
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C10ORF10 chromosome 10 open reading frame 10
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
GAB2 GRB2-associated binding protein 2
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IL17RB interleukin 17 receptor B
INSIG1 insulin induced gene 1
ISOC1 isochorismatase domain containing 1
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MBP myelin basic protein
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL1A oxysterol binding protein-like 1A
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PRELP proline/arginine-rich end leucine-rich repeat protein
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNMT RNA (guanine-7-) methyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
TCEAL2 transcription elongation factor A (SII)-like 2
TSPAN8 tetraspanin 8
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADCY9 adenylate cyclase 9
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ATF1 activating transcription factor 1
B3GNT1
BAG5 BCL2-associated athanogene 5
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCR7 chemokine (C-C motif) receptor 7
CDC20 cell division cycle 20
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP14 dual specificity phosphatase 14
ECI2 enoyl-CoA delta isomerase 2
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FZD7 frizzled class receptor 7
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS2L1 growth arrest-specific 2 like 1
GATA3 GATA binding protein 3
GPC4 glypican 4
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMG20B high mobility group 20B
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB6 homeobox B6
HOXB7 homeobox B7
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KANK2 KN motif and ankyrin repeat domains 2
KIF20A kinesin family member 20A
KLHL9 kelch-like family member 9
KRT10 keratin 10, type I
KRT6A keratin 6A, type II
LASP1 LIM and SH3 protein 1
MET MET proto-oncogene, receptor tyrosine kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MTCL1 microtubule crosslinking factor 1
MYCBP MYC binding protein
NPY1R neuropeptide Y receptor Y1
NTS neurotensin
OXTR oxytocin receptor
PAIP1 poly(A) binding protein interacting protein 1
PCGF2 polycomb group ring finger 2
PDZK1 PDZ domain containing 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PTCH1 patched 1
RAB5C RAB5C, member RAS oncogene family
RANBP6 RAN binding protein 6
RRAGA Ras-related GTP binding A
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SUB1 SUB1 homolog (S. cerevisiae)
TBC1D16 TBC1 domain family, member 16
TNC tenascin C
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UPK1B uroplakin 1B
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18