BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ARG2 arginase 2
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG3 BTG family, member 3
C5AR1 complement component 5a receptor 1
CCNL1 cyclin L1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTBS chitobiase, di-N-acetyl-
CTSZ cathepsin Z
CTTN cortactin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ENO2 enolase 2 (gamma, neuronal)
EPHA3 EPH receptor A3
FASN fatty acid synthase
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAGE3 G antigen 3
GPNMB glycoprotein (transmembrane) nmb
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6B lysine (K)-specific demethylase 6B
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PECR peroxisomal trans-2-enoyl-CoA reductase
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PGK1 phosphoglycerate kinase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RIOK3 RIO kinase 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SDC2 syndecan 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAI2 snail family zinc finger 2
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFRC transferrin receptor
TMEM45A transmembrane protein 45A
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZC2HC1A zinc finger, C2HC-type containing 1A
ZFP36 ZFP36 ring finger protein
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIM1 absent in melanoma 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFB1 defensin, beta 1
DUSP22 dual specificity phosphatase 22
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERLIN2 ER lipid raft associated 2
FABP4 fatty acid binding protein 4, adipocyte
FKBP11 FK506 binding protein 11, 19 kDa
FLT3 fms-related tyrosine kinase 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
H2AFX H2A histone family, member X
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL6ST interleukin 6 signal transducer
KANK1 KN motif and ankyrin repeat domains 1
KANK2 KN motif and ankyrin repeat domains 2
KRT7 keratin 7, type II
LMO2 LIM domain only 2 (rhombotin-like 1)
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NKG7 natural killer cell granule protein 7
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
OXTR oxytocin receptor
PDHB pyruvate dehydrogenase (lipoamide) beta
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBP1 retinol binding protein 1, cellular
RBPMS RNA binding protein with multiple splicing
RPA3 replication protein A3, 14kDa
RRP1B ribosomal RNA processing 1B
SACS sacsin molecular chaperone
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD7 SMAD family member 7
SOX11 SRY (sex determining region Y)-box 11
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE4 transducin-like enhancer of split 4
TSKU tsukushi, small leucine rich proteoglycan
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPK1B uroplakin 1B
VCAN versican