BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ALDOC aldolase C, fructose-bisphosphate
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CLDN7 claudin 7
COL11A1 collagen, type XI, alpha 1
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FMOD fibromodulin
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GAGE3 G antigen 3
GLUL glutamate-ammonia ligase
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
IQGAP1 IQ motif containing GTPase activating protein 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUP junction plakoglobin
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
MAP1A microtubule-associated protein 1A
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCCB propionyl CoA carboxylase, beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNX13 sorting nexin 13
STC1 stanniocalcin 1
SULF1 sulfatase 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
CBR3 carbonyl reductase 3
CCNF cyclin F
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
COG2 component of oligomeric golgi complex 2
CPB1 carboxypeptidase B1 (tissue)
DAPK1 death-associated protein kinase 1
DNAAF2 dynein, axonemal, assembly factor 2
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FXYD2 FXYD domain containing ion transport regulator 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXA10 homeobox A10
HOXA5 homeobox A5
IGHM immunoglobulin heavy constant mu
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
LGALS1 lectin, galactoside-binding, soluble, 1
LYPLA1 lysophospholipase I
MACF1 microtubule-actin crosslinking factor 1
MREG melanoregulin
MTCL1 microtubule crosslinking factor 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NID1 nidogen 1
NPY neuropeptide Y
NREP neuronal regeneration related protein
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
RPA3 replication protein A3, 14kDa
SLC25A46 solute carrier family 25, member 46
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTSSA serine palmitoyltransferase, small subunit A
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGM2 transglutaminase 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMX4 thioredoxin-related transmembrane protein 4
TRIB2 tribbles pseudokinase 2
VCAN versican
WWTR1 WW domain containing transcription regulator 1
YME1L1 YME1-like 1 ATPase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1