BRD-A18328003_GDC-0980_MCF10A_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-A18328003_GDC-0980_MCF10A_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACACB acetyl-CoA carboxylase beta
ACKR3 atypical chemokine receptor 3
ACSL1 acyl-CoA synthetase long-chain family member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
CXCR4 chemokine (C-X-C motif) receptor 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMD dystrophin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FOXO1 forkhead box O1
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GSN gelsolin
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HOXA5 homeobox A5
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
JAK1 Janus kinase 1
KIF14 kinesin family member 14
KLF9 Kruppel-like factor 9
LAMA4 laminin, alpha 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MATN2 matrilin 2
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
NEFH neurofilament, heavy polypeptide
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDGFD platelet derived growth factor D
PER1 period circadian clock 1
PNRC1 proline-rich nuclear receptor coactivator 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC35F2 solute carrier family 35, member F2
SPARCL1 SPARC-like 1 (hevin)
STOM stomatin
SYNE2 spectrin repeat containing, nuclear envelope 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAV3 vav 3 guanine nucleotide exchange factor
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AQP3 aquaporin 3 (Gill blood group)
CAPRIN2 caprin family member 2
CCND1 cyclin D1
CCNE2 cyclin E2
CD52 CD52 molecule
CDC25A cell division cycle 25A
CRABP1 cellular retinoic acid binding protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
EPHA2 EPH receptor A2
EREG epiregulin
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAM60A family with sequence similarity 60, member A
FGFBP1 fibroblast growth factor binding protein 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IER2 immediate early response 2
IER3 immediate early response 3
IL1B interleukin 1, beta
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LEF1 lymphoid enhancer-binding factor 1
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MALL mal, T-cell differentiation protein-like
MAT2A methionine adenosyltransferase II, alpha
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKX3-1 NK3 homeobox 1
NOP2 NOP2 nucleolar protein
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRD T cell receptor delta locus
TUBB2A tubulin, beta 2A class IIa
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZDHHC6 zinc finger, DHHC-type containing 6