BRD-A12083771_(3-isopropoxyphenyl){1-[(5-methyl-1-propyl-1H-pyrazol-4-yl)methyl]piperidin-3-yl}methanone_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-A12083771_(3-isopropoxyphenyl){1-[(5-methyl-1-propyl-1H-pyrazol-4-yl)methyl]piperidin-3-yl}methanone_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ADRB2 adrenoceptor beta 2, surface
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ATG3 autophagy related 3
CFB complement factor B
COMP cartilage oligomeric matrix protein
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FDPS farnesyl diphosphate synthase
FOS FBJ murine osteosarcoma viral oncogene homolog
FST follistatin
GBP1 guanylate binding protein 1, interferon-inducible
HDAC9 histone deacetylase 9
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INSIG1 insulin induced gene 1
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
MCTP1 multiple C2 domains, transmembrane 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP7 matrix metallopeptidase 7
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSPH phosphoserine phosphatase
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SC5D sterol-C5-desaturase
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SULF1 sulfatase 1
THBS1 thrombospondin 1
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L2 tumor protein D52-like 2
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
APOD apolipoprotein D
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
C2CD2 C2 calcium-dependent domain containing 2
CH25H cholesterol 25-hydroxylase
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CTTN cortactin
E2F2 E2F transcription factor 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IPO13 importin 13
MMP3 matrix metallopeptidase 3
MSX1 msh homeobox 1
PLIN2 perilipin 2
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
SEPP1 selenoprotein P, plasma, 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TCTA T-cell leukemia translocation altered
TUBB2A tubulin, beta 2A class IIa