BRD-A07765530_(+/-)-epinephrine_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-A07765530_(+/-)-epinephrine_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM1 absent in melanoma 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOB apolipoprotein B
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BEX1 brain expressed, X-linked 1
BHMT2 betaine--homocysteine S-methyltransferase 2
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
C3ORF14 chromosome 3 open reading frame 14
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM107A family with sequence similarity 107, member A
FGG fibrinogen gamma chain
FKBP5 FK506 binding protein 5
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM5 lysosomal protein transmembrane 5
LOX lysyl oxidase
LPL lipoprotein lipase
LRRC16A leucine rich repeat containing 16A
MAPT microtubule-associated protein tau
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
MYO1B myosin IB
NAV2 neuron navigator 2
NEBL nebulette
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGRN neugrin, neurite outgrowth associated
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
ORM1 orosomucoid 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM1 PDZ and LIM domain 1
PLIN2 perilipin 2
RAB25 RAB25, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A14 S100 calcium binding protein A14
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCRG1 stimulator of chondrogenesis 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SYBU syntabulin (syntaxin-interacting)
TACSTD2 tumor-associated calcium signal transducer 2
TERT telomerase reverse transcriptase
TF transferrin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VAMP8 vesicle-associated membrane protein 8
VCAN versican
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
CAPNS1 calpain, small subunit 1
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLIP2 CAP-GLY domain containing linker protein 2
CLU clusterin
CRISP3 cysteine-rich secretory protein 3
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA6 GATA binding protein 6
GNLY granulysin
GPI glucose-6-phosphate isomerase
GUSBP3 glucuronidase, beta pseudogene 3
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
JCHAIN joining chain of multimeric IgA and IgM
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LXN latexin
LYPD1 LY6/PLAUR domain containing 1
MAGEA1 melanoma antigen family A1
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPO myeloperoxidase
NKG7 natural killer cell granule protein 7
OLFM4 olfactomedin 4
PDGFD platelet derived growth factor D
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
PON2 paraoxonase 2
PRF1 perforin 1 (pore forming protein)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSPH phosphoserine phosphatase
PTCH1 patched 1
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RASA4 RAS p21 protein activator 4
RFC2 replication factor C (activator 1) 2, 40kDa
S100A12 S100 calcium binding protein A12
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STK32B serine/threonine kinase 32B
TBCB tubulin folding cofactor B
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM147 transmembrane protein 147
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D1 TSC22 domain family, member 1
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1