BRD-A04706586_Dibutyryl-cAMP, sodium salt_COV644_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

207 genes differentially expressed following the BRD-A04706586_Dibutyryl-cAMP, sodium salt_COV644_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKT3 v-akt murine thymoma viral oncogene homolog 3
APOC1 apolipoprotein C-I
ARMCX2 armadillo repeat containing, X-linked 2
C11ORF71 chromosome 11 open reading frame 71
C6ORF62 chromosome 6 open reading frame 62
CA1 carbonic anhydrase I
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CD52 CD52 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHGB chromogranin B
COL11A1 collagen, type XI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DACH1 dachshund family transcription factor 1
DCN decorin
DUOX2 dual oxidase 2
FOXE1 forkhead box E1
GNLY granulysin
GSE1 Gse1 coiled-coil protein
GUSBP11 glucuronidase, beta pseudogene 11
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HYOU1 hypoxia up-regulated 1
IFT74 intraflagellar transport 74
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IL7R interleukin 7 receptor
IRF9 interferon regulatory factor 9
ITGA8 integrin, alpha 8
JCHAIN joining chain of multimeric IgA and IgM
LDOC1 leucine zipper, down-regulated in cancer 1
LEF1 lymphoid enhancer-binding factor 1
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
MEF2C myocyte enhancer factor 2C
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MXRA5 matrix-remodelling associated 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAM1 neural cell adhesion molecule 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDGFC platelet derived growth factor C
PDLIM3 PDZ and LIM domain 3
PLA2G12A phospholipase A2, group XIIA
PLBD1 phospholipase B domain containing 1
PTPRD protein tyrosine phosphatase, receptor type, D
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RGS1 regulator of G-protein signaling 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
ST18 suppression of tumorigenicity 18, zinc finger
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
SULF1 sulfatase 1
TEK TEK tyrosine kinase, endothelial
TFPI2 tissue factor pathway inhibitor 2
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TYROBP TYRO protein tyrosine kinase binding protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WARS tryptophanyl-tRNA synthetase
WNK1 WNK lysine deficient protein kinase 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTB actin, beta
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ANXA2P2 annexin A2 pseudogene 2
AQP3 aquaporin 3 (Gill blood group)
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPNS1 calpain, small subunit 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD164 CD164 molecule, sialomucin
CD24 CD24 molecule
CD47 CD47 molecule
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLTC clathrin, heavy chain (Hc)
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL1A1 collagen, type I, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO1 enolase 1, (alpha)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
FHL2 four and a half LIM domains 2
FLNA filamin A, alpha
FOXJ3 forkhead box J3
GNAS GNAS complex locus
HN1 hematological and neurological expressed 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
JAK1 Janus kinase 1
KANK2 KN motif and ankyrin repeat domains 2
KPNB1 karyopherin (importin) beta 1
LAMP1 lysosomal-associated membrane protein 1
LASP1 LIM and SH3 protein 1
LIG1 ligase I, DNA, ATP-dependent
LYN LYN proto-oncogene, Src family tyrosine kinase
MALL mal, T-cell differentiation protein-like
MAPT microtubule-associated protein tau
METRN meteorin, glial cell differentiation regulator
MRPL12 mitochondrial ribosomal protein L12
MSRA methionine sulfoxide reductase A
MSX1 msh homeobox 1
NCOA4 nuclear receptor coactivator 4
NPC2 Niemann-Pick disease, type C2
NUTF2 nuclear transport factor 2
OXA1L oxidase (cytochrome c) assembly 1-like
PEBP1 phosphatidylethanolamine binding protein 1
PFKP phosphofructokinase, platelet
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSCA prostate stem cell antigen
PSPH phosphoserine phosphatase
PTMA prothymosin, alpha
RAB25 RAB25, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RBMS1 RNA binding motif, single stranded interacting protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RPP38 ribonuclease P/MRP 38kDa subunit
RPS26 ribosomal protein S26
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLIRP SRA stem-loop interacting RNA binding protein
SLPI secretory leukocyte peptidase inhibitor
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF6 serine/arginine-rich splicing factor 6
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STEAP3 STEAP family member 3, metalloreductase
STOM stomatin
STX3 syntaxin 3
SUCO SUN domain containing ossification factor
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR3 transforming growth factor, beta receptor III
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TNS1 tensin 1
TRAM1 translocation associated membrane protein 1
TRIM16 tripartite motif containing 16
TRIM28 tripartite motif containing 28
TSPAN8 tetraspanin 8
TSTA3 tissue specific transplantation antigen P35B
TUBB tubulin, beta class I
TXN thioredoxin
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VAT1 vesicle amine transport 1
WSB2 WD repeat and SOCS box containing 2
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)