Autistic Disorder Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years. (Human Disease Ontology, DOID_12849)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D001321
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Genes

273 genes/proteins associated with the disease Autistic Disorder from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
ADA adenosine deaminase 2.88009
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 2.88009
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 2.88009
CSMD3 CUB and Sushi multiple domains 3 2.88009
MEF2C myocyte enhancer factor 2C 2.88009
PRL prolactin 2.88009
DPYD dihydropyrimidine dehydrogenase 2.88009
DOCK4 dedicator of cytokinesis 4 2.88009
GRIA1 glutamate receptor, ionotropic, AMPA 1 2.88009
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.88009
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.88009
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.88009
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.88009
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 2.88009
PLD5 phospholipase D family, member 5 2.88009
PAX6 paired box 6 2.88009
GSTM1 glutathione S-transferase mu 1 2.88009
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 2.88009
XDH xanthine dehydrogenase 2.88009
BTD biotinidase 2.88009
C3ORF58 chromosome 3 open reading frame 58 2.88009
ADRB2 adrenoceptor beta 2, surface 2.88009
NBEA neurobeachin 2.88009
PON1 paraoxonase 1 2.88009
GPR155 G protein-coupled receptor 155 2.88009
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.88009
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.88009
CNTNAP2 contactin associated protein-like 2 2.88009
UPB1 ureidopropionase, beta 2.88009
LASP1 LIM and SH3 protein 1 2.88009
NF1 neurofibromin 1 2.88009
PECAM1 platelet/endothelial cell adhesion molecule 1 2.88009
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 2.88009
NRXN1 neurexin 1 2.88009
KDM5C lysine (K)-specific demethylase 5C 2.88009
BDNF brain-derived neurotrophic factor 2.88009
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.88009
SNTG2 syntrophin, gamma 2 2.88009
VLDLR very low density lipoprotein receptor 2.88009
TDO2 tryptophan 2,3-dioxygenase 2.88009
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.88009
MIR106B microRNA 106b 2.88009
LEP leptin 2.88009
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 2.88009
EN2 engrailed homeobox 2 2.88009
DEL16P11.2 autism, susceptibility to, 14 2.88009
TPH2 tryptophan hydroxylase 2 2.88009
MYO1D myosin ID 2.88009
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.88009
CAT catalase 2.88009
ASMT acetylserotonin O-methyltransferase 2.88009
UBE2H ubiquitin-conjugating enzyme E2H 2.88009
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 2.88009
OXTR oxytocin receptor 2.88009
PRLR prolactin receptor 2.88009
PER1 period circadian clock 1 2.88009
MCC mutated in colorectal cancers 2.88009
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 2.88009
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 2.88009
OXT oxytocin/neurophysin I prepropeptide 2.88009
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.88009
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.88009
AVP arginine vasopressin 2.88009
GRM8 glutamate receptor, metabotropic 8 2.88009
ADM adrenomedullin 2.88009
PDE4B phosphodiesterase 4B, cAMP-specific 2.88009
GPX1 glutathione peroxidase 1 2.88009
CNTN4 contactin 4 2.88009
CNTN3 contactin 3 (plasmacytoma associated) 2.88009
ASIC2 acid sensing (proton gated) ion channel 2 2.88009
IL1RN interleukin 1 receptor antagonist 2.88009
CP ceruloplasmin (ferroxidase) 2.88009
PTCHD1 patched domain containing 1 2.88009
DHCR7 7-dehydrocholesterol reductase 2.88009
EGF epidermal growth factor 2.88009
AR androgen receptor 2.88009
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase 2.88009
SCN7A sodium channel, voltage gated, type VII alpha subunit 2.88009
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 2.88009
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 2.88009
MIR23A microRNA 23a 2.88009
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa 2.88009
PDE4A phosphodiesterase 4A, cAMP-specific 2.88009
STATH statherin 2.88009
SND1 staphylococcal nuclease and tudor domain containing 1 2.88009
AVPR1A arginine vasopressin receptor 1A 2.88009
SYNGAP1 synaptic Ras GTPase activating protein 1 2.88009
CADM1 cell adhesion molecule 1 2.88009
MTF1 metal-regulatory transcription factor 1 2.88009
STK39 serine threonine kinase 39 2.88009
STX1A syntaxin 1A (brain) 2.88009
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.88009
DHFR dihydrofolate reductase 2.88009
SCAMP5 secretory carrier membrane protein 5 2.88009
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 2.88009
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.88009
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 2.88009
IL2 interleukin 2 2.88009
MBD4 methyl-CpG binding domain protein 4 2.88009
POMC proopiomelanocortin 2.88009
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 2.88009
PTEN phosphatase and tensin homolog 2.88009
MECP2 methyl CpG binding protein 2 2.88009
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.88009
PLAUR plasminogen activator, urokinase receptor 2.88009
GJA1 gap junction protein, alpha 1, 43kDa 2.88009
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 2.88009
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.88009
CDH9 cadherin 9, type 2 (T1-cadherin) 2.88009
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.88009
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 2.88009
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 2.88009
MBD3 methyl-CpG binding domain protein 3 2.88009
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 2.88009
IL5 interleukin 5 2.88009
IL4 interleukin 4 2.88009
IL6 interleukin 6 2.88009
RPL10 ribosomal protein L10 2.88009
PRKCB protein kinase C, beta 2.88009
STXBP6 syntaxin binding protein 6 (amisyn) 2.88009
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.88009
CALCA calcitonin-related polypeptide alpha 2.88009
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.88009
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.88009
DAO D-amino-acid oxidase 2.88009
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.88009
PARK2 parkin RBR E3 ubiquitin protein ligase 2.88009
VIP vasoactive intestinal peptide 2.88009
PASK PAS domain containing serine/threonine kinase 2.88009
CDH10 cadherin 10, type 2 (T2-cadherin) 2.88009
GLO1 glyoxalase I 2.88009
NTF4 neurotrophin 4 2.88009
IGF1 insulin-like growth factor 1 (somatomedin C) 2.88009
IGF2 insulin-like growth factor 2 2.88009
RELN reelin 2.88009
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 2.88009
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 2.88009
AHI1 Abelson helper integration site 1 2.88009
MAOA monoamine oxidase A 2.88009
MAOB monoamine oxidase B 2.88009
EXT1 exostosin glycosyltransferase 1 2.88009
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.88009
TF transferrin 2.88009
EGR2 early growth response 2 2.88009
FBXO40 F-box protein 40 2.88009
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.88009
POU6F2 POU class 6 homeobox 2 2.88009
ACADSB acyl-CoA dehydrogenase, short/branched chain 2.88009
HTN1 histatin 1 2.88009
DRD1 dopamine receptor D1 2.88009
DRD3 dopamine receptor D3 2.88009
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 2.88009
NTF3 neurotrophin 3 2.88009
VWA8 von Willebrand factor A domain containing 8 2.88009
IL15 interleukin 15 2.88009
IL13 interleukin 13 2.88009
IL10 interleukin 10 2.88009
COMT catechol-O-methyltransferase 2.88009
PCDH10 protocadherin 10 2.88009
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.88009
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.88009
NLGN3 neuroligin 3 2.88009
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 2.88009
ADSL adenylosuccinate lyase 2.88009
ASTN2 astrotactin 2 2.88009
LAMB1 laminin, beta 1 2.88009
SHANK1 SH3 and multiple ankyrin repeat domains 1 2.88009
SHANK2 SH3 and multiple ankyrin repeat domains 2 2.88009
SHANK3 SH3 and multiple ankyrin repeat domains 3 2.88009
WNT2 wingless-type MMTV integration site family member 2 2.88009
MACROD2 MACRO domain containing 2 2.88009
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 2.88009
ABAT 4-aminobutyrate aminotransferase 2.88009
CADPS2 Ca++-dependent secretion activator 2 2.88009
C4B complement component 4B (Chido blood group) 2.88009
BCL2 B-cell CLL/lymphoma 2 2.88009
HLA-A major histocompatibility complex, class I, A 2.88009
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2.88009
NLGN1 neuroligin 1 2.88009
NRP2 neuropilin 2 2.88009
INPP1 inositol polyphosphate-1-phosphatase 2.88009
DLX2 distal-less homeobox 2 2.88009
DLX1 distal-less homeobox 1 2.88009
NRCAM neuronal cell adhesion molecule 2.88009
ATP10A ATPase, class V, type 10A 2.88009
HOXA1 homeobox A1 2.88009
NLGN4X neuroligin 4, X-linked 2.88009
FMR1 fragile X mental retardation 1 2.88009
MARK1 MAP/microtubule affinity-regulating kinase 1 2.88009
MAGEL2 melanoma antigen family L2 2.88009
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 2.88009
SEZ6L2 seizure related 6 homolog (mouse)-like 2 2.88009
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.88009
REEP3 receptor accessory protein 3 2.88009
MET MET proto-oncogene, receptor tyrosine kinase 2.88009
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.88009
GSTP1 glutathione S-transferase pi 1 2.88009
IFNG interferon, gamma 2.88009
FOXP2 forkhead box P2 2.88009
PRF1 perforin 1 (pore forming protein) 2.88009
IGFBP3 insulin-like growth factor binding protein 3 2.88009
ADNP activity-dependent neuroprotector homeobox 2.88009
APC adenomatous polyposis coli 2.88009
XPC xeroderma pigmentosum, complementation group C 2.88009
RORA RAR-related orphan receptor A 2.88009
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.88009
TCN2 transcobalamin II 2.88009
NSD1 nuclear receptor binding SET domain protein 1 2.88009
NOS2 nitric oxide synthase 2, inducible 2.88009
NPAS2 neuronal PAS domain protein 2 2.88009
AUTS13 autism, susceptibility to, 13 2.88009
AUTS12 autism, susceptibility to, 12 2.88009
AUTS11 Autism, susceptibility to, 11 2.88009
GHR growth hormone receptor 2.88009
DISC1 disrupted in schizophrenia 1 2.88009
RAB39B RAB39B, member RAS oncogene family 2.88009
HDLBP high density lipoprotein binding protein 2.88009
ZMYND11 zinc finger, MYND-type containing 11 2.88009
GRIK2 glutamate receptor, ionotropic, kainate 2 2.88009
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 2.88009
AUTS7 Autism, susceptibility to, 7 2.88009
TSC1 tuberous sclerosis 1 2.88009
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 2.88009
UBE3A ubiquitin protein ligase E3A 2.88009
HRAS Harvey rat sarcoma viral oncogene homolog 2.88009
JMJD1C jumonji domain containing 1C 2.88009
HOXD11 homeobox D11 2.88009
PITX1 paired-like homeodomain 1 2.88009
JAKMIP1 janus kinase and microtubule interacting protein 1 2.88009
SCT secretin 2.88009
TSC2 tuberous sclerosis 2 2.88009
AUTS5 Autism, susceptibility to, 5 2.88009
AUTS3 Autism, susceptibility to, 3 2.88009
AUTS1 Autism, susceptibility to, 1 2.88009
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2.88009
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.88009
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 2.88009
AQP4 aquaporin 4 2.88009
AUTS6 Autism, susceptibility to, 6 2.88009
SLC19A1 solute carrier family 19 (folate transporter), member 1 2.88009
AUTS8 Autism, susceptibility to, 8 2.88009
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.42293
FOS FBJ murine osteosarcoma viral oncogene homolog 1.35271
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.34111
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.29225
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.27132
TNF tumor necrosis factor 1.26886
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.22727
MAPK1 mitogen-activated protein kinase 1 1.20978
SOD1 superoxide dismutase 1, soluble 1.20262
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 1.16866
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.15324
CREB1 cAMP responsive element binding protein 1 1.14644
MAPK8 mitogen-activated protein kinase 8 1.12219
MAPK3 mitogen-activated protein kinase 3 1.11945
IL1B interleukin 1, beta 1.10838
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1.10665
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.10353
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.09154
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.08584
ZFP14 ZFP14 zinc finger protein 1.08196
DUSP1 dual specificity phosphatase 1 1.07983
MZF1 myeloid zinc finger 1 1.07269
PFDN4 prefoldin subunit 4 1.059
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.04794
ZNF687 zinc finger protein 687 1.04684
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 1.04574
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.04163
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 1.03678
GSK3B glycogen synthase kinase 3 beta 1.03308
DRD2 dopamine receptor D2 1.01739
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.01549
RTP3 receptor (chemosensory) transporter protein 3 1.01361