Attention Deficit Disorder with Hyperactivity Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D001289
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Genes

265 genes/proteins associated with the disease Attention Deficit Disorder with Hyperactivity from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
TPH2 tryptophan hydroxylase 2 2.88009
PTPRD protein tyrosine phosphatase, receptor type, D 2.88009
GRM5 glutamate receptor, metabotropic 5 2.88009
GRM7 glutamate receptor, metabotropic 7 2.88009
GRM1 glutamate receptor, metabotropic 1 2.88009
DRD4 dopamine receptor D4 2.88009
COMT catechol-O-methyltransferase 2.88009
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.88009
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.88009
FGD1 FYVE, RhoGEF and PH domain containing 1 2.88009
DRD2 dopamine receptor D2 2.88009
GRM8 glutamate receptor, metabotropic 8 2.88009
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 2.88009
DRD5 dopamine receptor D5 2.88009
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 2.88009
ADHD4 Attention deficit-hyperactivity disorder, susceptibility to, 4 2.88009
ADHD5 Attention deficit-hyperactivity disorder, susceptibility to, 5 2.88009
STS steroid sulfatase (microsomal), isozyme S 2.88009
ADHD6 Attention deficit-hyperactivity disorder, susceptibility to, 6 2.88009
ADHD1 Attention deficit-hyperactivity disorder, susceptibility to, 1 2.88009
TACR1 tachykinin receptor 1 2.88009
ADHD2 Attention deficit-hyperactivity disorder, susceptibility to, 2 2.88009
CNR1 cannabinoid receptor 1 (brain) 2.88009
ADHD3 Attention deficit-hyperactivity disorder, susceptibility to, 2 2.88009
FOS FBJ murine osteosarcoma viral oncogene homolog 2.30536
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.18504
BDNF brain-derived neurotrophic factor 2.17059
CAT catalase 2.04084
MAPK1 mitogen-activated protein kinase 1 1.97655
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.96462
EGR1 early growth response 1 1.93137
JUN jun proto-oncogene 1.91797
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.87908
TH tyrosine hydroxylase 1.87526
DRD1 dopamine receptor D1 1.85922
ARC activity-regulated cytoskeleton-associated protein 1.85098
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.84233
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.82621
DUSP1 dual specificity phosphatase 1 1.81092
GFAP glial fibrillary acidic protein 1.80793
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.79808
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.79025
PRL prolactin 1.7782
TNF tumor necrosis factor 1.77743
MAPK3 mitogen-activated protein kinase 3 1.77705
GSTP1 glutathione S-transferase pi 1 1.75915
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.7562
CREB1 cAMP responsive element binding protein 1 1.74421
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.72509
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.7045
SOD1 superoxide dismutase 1, soluble 1.69576
MAOA monoamine oxidase A 1.68676
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.67398
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.67246
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.63721
MAOB monoamine oxidase B 1.63294
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.63094
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.61154
NPY neuropeptide Y 1.59661
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.57546
POMC proopiomelanocortin 1.57018
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.56828
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.55846
GAL galanin/GMAP prepropeptide 1.555
ERN1 endoplasmic reticulum to nucleus signaling 1 1.52237
GAP43 growth associated protein 43 1.51683
FABP1 fatty acid binding protein 1, liver 1.5133
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.5118
IL6 interleukin 6 1.50524
BCL2 B-cell CLL/lymphoma 2 1.50423
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.49787
MAPK8 mitogen-activated protein kinase 8 1.49508
BAX BCL2-associated X protein 1.4933
PAX8 paired box 8 1.49148
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.48993
DRD3 dopamine receptor D3 1.48479
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.4794
SYP synaptophysin 1.46251
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.44899
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.44409
DDIT3 DNA-damage-inducible transcript 3 1.44355
HMOX1 heme oxygenase 1 1.43455
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.42374
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.42101
NFE2L2 nuclear factor, erythroid 2-like 2 1.42074
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.42074
PENK proenkephalin 1.41938
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.41532
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.41505
GSTM1 glutathione S-transferase mu 1 1.4012
CRH corticotropin releasing hormone 1.39646
HSPA8 heat shock 70kDa protein 8 1.39198
TAAR1 trace amine associated receptor 1 1.38669
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.37504
HDAC1 histone deacetylase 1 1.3736
NUPR1 nuclear protein, transcriptional regulator, 1 1.36905
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.36418
HOMER1 homer scaffolding protein 1 1.36133
ATF4 activating transcription factor 4 1.35444
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.34372
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.34285
HSPA1A heat shock 70kDa protein 1A 1.3414
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.34082
NOS2 nitric oxide synthase 2, inducible 1.3385
CCND1 cyclin D1 1.33731
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.33464
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.32993
ADORA1 adenosine A1 receptor 1.32726
COX7C cytochrome c oxidase subunit VIIc 1.3231
ACHE acetylcholinesterase (Yt blood group) 1.3228
GSR glutathione reductase 1.31506
NOS1 nitric oxide synthase 1 (neuronal) 1.31446
PPARG peroxisome proliferator-activated receptor gamma 1.29812
PRKCA protein kinase C, alpha 1.29471
GDNF glial cell derived neurotrophic factor 1.2861
DUSP6 dual specificity phosphatase 6 1.28549
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.28333
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.27751
JUNB jun B proto-oncogene 1.27626
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.27471
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.27316
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.27316
PDYN prodynorphin 1.27193
XDH xanthine dehydrogenase 1.26144
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 1.2596
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.25745
TFRC transferrin receptor 1.25557
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.25028
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.24843
IL1B interleukin 1, beta 1.24655
XBP1 X-box binding protein 1 1.24465
STAR steroidogenic acute regulatory protein 1.2415
SOD2 superoxide dismutase 2, mitochondrial 1.2415
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.23265
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.23074
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.23042
SCARB1 scavenger receptor class B, member 1 1.22853
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.22501
APOA2 apolipoprotein A-II 1.22469
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.22469
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.21435
TJP1 tight junction protein 1 1.19672
AR androgen receptor 1.19445
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.18059
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 1.17827
FAS Fas cell surface death receptor 1.17827
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 1.17728
RGS2 regulator of G-protein signaling 2 1.17695
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.17695
EFNA2 ephrin-A2 1.17662
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.17431
GSTT1 glutathione S-transferase theta 1 1.17366
PRKCB protein kinase C, beta 1.17268
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1.17101
EFNA1 ephrin-A1 1.17101
CRP C-reactive protein, pentraxin-related 1.169
STIP1 stress-induced phosphoprotein 1 1.16799
MAP2K1 mitogen-activated protein kinase kinase 1 1.16733
IL10 interleukin 10 1.16533
MAP2 microtubule-associated protein 2 1.165
NTS neurotensin 1.165
VEGFA vascular endothelial growth factor A 1.16035
PDIA6 protein disulfide isomerase family A, member 6 1.15593
SOAT1 sterol O-acyltransferase 1 1.15391
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 1.14919
PRKCG protein kinase C, gamma 1.14919
LEP leptin 1.14747
GSK3A glycogen synthase kinase 3 alpha 1.14438
CXCL2 chemokine (C-X-C motif) ligand 2 1.14404
PARP1 poly (ADP-ribose) polymerase 1 1.142
INHBE inhibin, beta E 1.14166
PER2 period circadian clock 2 1.13895
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.13862
CDK5 cyclin-dependent kinase 5 1.13552
INHA inhibin, alpha 1.13552
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 1.13552
UBB ubiquitin B 1.13552
SREBF1 sterol regulatory element binding transcription factor 1 1.13518
SYT5 synaptotagmin V 1.13245
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 1.12703
EYA2 EYA transcriptional coactivator and phosphatase 2 1.12461
ADRA1B adrenoceptor alpha 1B 1.12288
TTR transthyretin 1.1198
FASN fatty acid synthase 1.11466
TAC1 tachykinin, precursor 1 1.11325
IGFBP1 insulin-like growth factor binding protein 1 1.11255
IFNG interferon, gamma 1.1122
MAPT microtubule-associated protein tau 1.11081
POR P450 (cytochrome) oxidoreductase 1.10769
NQO1 NAD(P)H dehydrogenase, quinone 1 1.10734
CKB creatine kinase, brain 1.10734
ELOVL6 ELOVL fatty acid elongase 6 1.10493
ADORA2A adenosine A2a receptor 1.10493
PLCD4 phospholipase C, delta 4 1.10282
EFNB3 ephrin-B3 1.10282
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 1.10246
VCAM1 vascular cell adhesion molecule 1 1.10211
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.09998
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 1.09892
ACSL5 acyl-CoA synthetase long-chain family member 5 1.09857
TP53 tumor protein p53 1.09822
BID BH3 interacting domain death agonist 1.09716
LARGE like-glycosyltransferase 1.09576
NR1H3 nuclear receptor subfamily 1, group H, member 3 1.09506
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.09506
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 1.09471
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 1.09366
MSMO1 methylsterol monooxygenase 1 1.09262
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.09119
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 1.08868
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.08762
PRKCD protein kinase C, delta 1.08337
GCLC glutamate-cysteine ligase, catalytic subunit 1.07804
CFH complement factor H 1.07625
CCL2 chemokine (C-C motif) ligand 2 1.07589
RFC1 replication factor C (activator 1) 1, 145kDa 1.07553
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.07376
FN1 fibronectin 1 1.0734
GSTA4 glutathione S-transferase alpha 4 1.0734
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.0734
FNDC4 fibronectin type III domain containing 4 1.07022
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 1.06917
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.06698
IL1A interleukin 1, alpha 1.06552
ALPP alkaline phosphatase, placental 1.06333
SREBF2 sterol regulatory element binding transcription factor 2 1.06261
ACACB acetyl-CoA carboxylase beta 1.06261
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.06225
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.06008
ADIPOR2 adiponectin receptor 2 1.05573
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.04904
IGF1 insulin-like growth factor 1 (somatomedin C) 1.04684
GRK6 G protein-coupled receptor kinase 6 1.04574
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 1.04276
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.04276
POU5F1 POU class 5 homeobox 1 1.04239
GLUL glutamate-ammonia ligase 1.03827
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.0353
GSK3B glycogen synthase kinase 3 beta 1.03456
MAP2K7 mitogen-activated protein kinase kinase 7 1.03419
GPX2 glutathione peroxidase 2 1.03235
RPP21 ribonuclease P/MRP 21kDa subunit 1.03046
RARA retinoic acid receptor, alpha 1.03009
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.02933
CTNND1 catenin (cadherin-associated protein), delta 1 1.02896
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 1.02896
ARNT aryl hydrocarbon receptor nuclear translocator 1.02821
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.02821
RGS4 regulator of G-protein signaling 4 1.02671
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.02559
UBC ubiquitin C 1.02373
VWF von Willebrand factor 1.02373
ACACA acetyl-CoA carboxylase alpha 1.02225
GJA1 gap junction protein, alpha 1, 43kDa 1.02151
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 1.0189
CD82 CD82 molecule 1.01852
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1.01852
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1.01852
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.01814
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.01625
GMFB glia maturation factor, beta 1.01361
ANGPTL4 angiopoietin-like 4 1.01249
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 1.01174
TXNIP thioredoxin interacting protein 1.01025
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.01025