Astrocytoma Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A malignant glioma that is has_material_basis_in astocyte cells, a type of star-shaped glial cell, located_in the cerebrum. (Human Disease Ontology, DOID_3069)
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Genes

45 genes associated with the Astrocytoma phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
APC adenomatous polyposis coli
BRAF B-Raf proto-oncogene, serine/threonine kinase
CCDC26 CCDC26 long non-coding RNA
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DMBT1 deleted in malignant brain tumors 1
EGFR epidermal growth factor receptor
ERCC2 excision repair cross-complementation group 2
FGFR1 fibroblast growth factor receptor 1
FLT3 fms-related tyrosine kinase 3
GLTSCR1 glioma tumor suppressor candidate region gene 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
H3F3A H3 histone, family 3A
HRAS Harvey rat sarcoma viral oncogene homolog
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MGMT O-6-methylguanine-DNA methyltransferase
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBN nibrin
NF1 neurofibromin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PON1 paraoxonase 1
PTEN phosphatase and tensin homolog
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RTEL1 regulator of telomere elongation helicase 1
TERT telomerase reverse transcriptase
TP53 tumor protein p53
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TYMS thymidylate synthetase
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4