Arthritis Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint. (Human Disease Ontology, DOID_848)
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Genes

57 genes associated with the Arthritis phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
AFF3 AF4/FMR2 family, member 3
C5 complement component 5
CARD8 caspase recruitment domain family, member 8
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD226 CD226 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
COL2A1 collagen, type II, alpha 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DBP D site of albumin promoter (albumin D-box) binding protein
FCRL3 Fc receptor-like 3
HFE hemochromatosis
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFNG interferon, gamma
IL10 interleukin 10
IL12A interleukin 12A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL6 interleukin 6
IL7R interleukin 7 receptor
IRF7 interferon regulatory factor 7
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KIF5A kinesin family member 5A
LTA lymphotoxin alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MEFV Mediterranean fever
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
PADI4 peptidyl arginine deiminase, type IV
PARP1 poly (ADP-ribose) polymerase 1
PRKCQ protein kinase C, theta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PYCARD PYD and CARD domain containing
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RSBN1 round spermatid basic protein 1
STAT4 signal transducer and activator of transcription 4
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAF1 TNF receptor-associated factor 1
WRN Werner syndrome, RecQ helicase-like