Arthritis Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint. (Human Disease Ontology, DOID_848)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D001168
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Genes

201 genes/proteins associated with the disease Arthritis from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
HP haptoglobin 2.88009
COL2A1 collagen, type II, alpha 1 2.88009
ZFP36 ZFP36 ring finger protein 2.88009
CD69 CD69 molecule 2.88009
IL6 interleukin 6 2.21455
IL1B interleukin 1, beta 2.11911
IL10 interleukin 10 2.11009
TNF tumor necrosis factor 1.99408
NOS2 nitric oxide synthase 2, inducible 1.92218
IFNG interferon, gamma 1.89074
IL4 interleukin 4 1.85362
IL2 interleukin 2 1.8128
CCL2 chemokine (C-C motif) ligand 2 1.79598
DDIT3 DNA-damage-inducible transcript 3 1.79331
CCL5 chemokine (C-C motif) ligand 5 1.73373
BAX BCL2-associated X protein 1.72405
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.70161
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.68633
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.6636
BCL2L1 BCL2-like 1 1.64865
MPO myeloperoxidase 1.63384
TIMP2 TIMP metallopeptidase inhibitor 2 1.59755
BCL2 B-cell CLL/lymphoma 2 1.59731
MBP myelin basic protein 1.59661
CAT catalase 1.5816
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.57994
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.57474
APP amyloid beta (A4) precursor protein 1.57042
CXCL8 chemokine (C-X-C motif) ligand 8 1.55946
GSTT1 glutathione S-transferase theta 1 1.55329
VEGFA vascular endothelial growth factor A 1.55157
JUN jun proto-oncogene 1.55084
GSK3B glycogen synthase kinase 3 beta 1.53283
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.53184
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.53086
DUSP1 dual specificity phosphatase 1 1.50877
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.50473
TP53 tumor protein p53 1.50423
HMOX1 heme oxygenase 1 1.50348
BID BH3 interacting domain death agonist 1.48479
CCL3 chemokine (C-C motif) ligand 3 1.48017
FAS Fas cell surface death receptor 1.46041
IL1A interleukin 1, alpha 1.45697
S100A9 S100 calcium binding protein A9 1.4567
ICAM1 intercellular adhesion molecule 1 1.44763
IGF1 insulin-like growth factor 1 (somatomedin C) 1.44029
PPARA peroxisome proliferator-activated receptor alpha 1.43021
MMP9 matrix metallopeptidase 9 1.41856
CFLAR CASP8 and FADD-like apoptosis regulator 1.41613
ALB albumin 1.41532
XDH xanthine dehydrogenase 1.41532
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.40705
PPARG peroxisome proliferator-activated receptor gamma 1.40541
EDNRB endothelin receptor type B 1.40373
BAK1 BCL2-antagonist/killer 1 1.40008
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.39869
XBP1 X-box binding protein 1 1.38669
VCAM1 vascular cell adhesion molecule 1 1.38469
RB1 retinoblastoma 1 1.37987
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.36706
MMP3 matrix metallopeptidase 3 1.36533
GCLC glutamate-cysteine ligase, catalytic subunit 1.36304
CCND1 cyclin D1 1.36104
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.34256
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.33612
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.33553
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.33523
PPARD peroxisome proliferator-activated receptor delta 1.3231
EGFR epidermal growth factor receptor 1.31237
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.31237
CTGF connective tissue growth factor 1.31148
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.31119
MMP2 matrix metallopeptidase 2 1.31059
TIMP3 TIMP metallopeptidase inhibitor 3 1.30758
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.30543
FOS FBJ murine osteosarcoma viral oncogene homolog 1.30026
CLU clusterin 1.29533
GADD45A growth arrest and DNA-damage-inducible, alpha 1.29225
MCL1 myeloid cell leukemia 1 1.28889
ASS1 argininosuccinate synthase 1 1.28549
ATF6 activating transcription factor 6 1.2744
COL1A1 collagen, type I, alpha 1 1.27409
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.27347
TGFB2 transforming growth factor, beta 2 1.27255
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.26763
POR P450 (cytochrome) oxidoreductase 1.26267
CXCL10 chemokine (C-X-C motif) ligand 10 1.26144
MMP13 matrix metallopeptidase 13 1.26052
SOD1 superoxide dismutase 1, soluble 1.25838
SOD2 superoxide dismutase 2, mitochondrial 1.25557
IL12A interleukin 12A 1.25557
LCN2 lipocalin 2 1.25245
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.25214
GSTP1 glutathione S-transferase pi 1 1.2509
PARP1 poly (ADP-ribose) polymerase 1 1.25059
EGR1 early growth response 1 1.24465
STAT5B signal transducer and activator of transcription 5B 1.24338
IL12B interleukin 12B 1.23296
MAPK14 mitogen-activated protein kinase 14 1.23074
PLIN2 perilipin 2 1.2279
IL13 interleukin 13 1.22112
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.21663
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.21239
POMC proopiomelanocortin 1.20913
IGFBP3 insulin-like growth factor binding protein 3 1.20784
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.20097
LDLR low density lipoprotein receptor 1.20064
NOS3 nitric oxide synthase 3 (endothelial cell) 1.20031
BMP4 bone morphogenetic protein 4 1.19737
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.19737
MAPK1 mitogen-activated protein kinase 1 1.19704
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.19672
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.19412
LEP leptin 1.19379
TGFB1 transforming growth factor, beta 1 1.19345
BACE1 beta-site APP-cleaving enzyme 1 1.19179
TIMP1 TIMP metallopeptidase inhibitor 1 1.18783
PDGFA platelet-derived growth factor alpha polypeptide 1.18718
BIRC5 baculoviral IAP repeat containing 5 1.18193
BAD BCL2-associated agonist of cell death 1.17497
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.17034
PRKCB protein kinase C, beta 1.16766
FASLG Fas ligand (TNF superfamily, member 6) 1.16467
LPIN1 lipin 1 1.16302
BBC3 BCL2 binding component 3 1.16203
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.15899
CCNB1 cyclin B1 1.15729
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.1556
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.15458
GRIK2 glutamate receptor, ionotropic, kainate 2 1.15458
MAP2K2 mitogen-activated protein kinase kinase 2 1.15089
SELL selectin L 1.14575
TBX21 T-box 21 1.14438
RGS4 regulator of G-protein signaling 4 1.14268
CDK4 cyclin-dependent kinase 4 1.14234
GSTM1 glutathione S-transferase mu 1 1.14166
CYCS cytochrome c, somatic 1.14098
COL3A1 collagen, type III, alpha 1 1.13689
NPY neuropeptide Y 1.13518
PCNA proliferating cell nuclear antigen 1.13484
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.12973
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.12737
ACAN aggrecan 1.12391
SGK1 serum/glucocorticoid regulated kinase 1 1.12357
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.12288
F3 coagulation factor III (thromboplastin, tissue factor) 1.12014
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.11571
CTSB cathepsin B 1.11396
GATA3 GATA binding protein 3 1.1136
MAPK3 mitogen-activated protein kinase 3 1.11186
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.10907
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.10459
ATF3 activating transcription factor 3 1.10459
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 1.09262
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.09226
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.09083
NQO1 NAD(P)H dehydrogenase, quinone 1 1.08975
UNG uracil-DNA glycosylase 1.0894
ASL argininosuccinate lyase 1.08797
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.08726
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.08549
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.08478
GFAP glial fibrillary acidic protein 1.08337
FADS2 fatty acid desaturase 2 1.08266
POU2F1 POU class 2 homeobox 1 1.07983
KLF4 Kruppel-like factor 4 (gut) 1.07804
FOXO1 forkhead box O1 1.07589
CBLN1 cerebellin 1 precursor 1.07482
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 1.07163
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.06952
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.06917
CXCL2 chemokine (C-X-C motif) ligand 2 1.06442
SPP1 secreted phosphoprotein 1 1.06225
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.0608
IRF9 interferon regulatory factor 9 1.05685
RHOB ras homolog family member B 1.05648
FMO1 flavin containing monooxygenase 1 1.05648
FGFR1 fibroblast growth factor receptor 1 1.05423
FSHB follicle stimulating hormone, beta polypeptide 1.05237
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 1.052
MAP2K1 mitogen-activated protein kinase kinase 1 1.05089
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.05015
SCRG1 stimulator of chondrogenesis 1 1.04978
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 1.04427
IL1R1 interleukin 1 receptor, type I 1.04201
PLAT plasminogen activator, tissue 1.03901
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.03641
APOE apolipoprotein E 1.0353
VAV1 vav 1 guanine nucleotide exchange factor 1.03456
EFNA4 ephrin-A4 1.03456
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.02634
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.02262
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.02077
EYA2 EYA transcriptional coactivator and phosphatase 2 1.01928
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.01852
FMO3 flavin containing monooxygenase 3 1.01587
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.01512
GPX2 glutathione peroxidase 2 1.01324
STAR steroidogenic acute regulatory protein 1.01286
TNNI3 troponin I type 3 (cardiac) 1.01249
COL11A1 collagen, type XI, alpha 1 1.01249