Arteriosclerosis Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries. (Human Disease Ontology, DOID_2349)
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Genes

90 genes associated with the Arteriosclerosis phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACE angiotensin I converting enzyme
ADD1 adducin 1 (alpha)
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
AR androgen receptor
CAPN10 calpain 10
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CETP cholesteryl ester transfer protein, plasma
CRP C-reactive protein, pentraxin-related
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBA cytochrome b-245, alpha polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGB fibrinogen beta chain
GDF15 growth differentiation factor 15
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HFE hemochromatosis
HMOX1 heme oxygenase 1
HSPA4 heat shock 70kDa protein 4
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
LDLR low density lipoprotein receptor
LIPC lipase, hepatic
LPL lipoprotein lipase
LTA lymphotoxin alpha
LTC4S leukotriene C4 synthase
MBL2 mannose-binding lectin (protein C) 2, soluble
MGP matrix Gla protein
MMP13 matrix metallopeptidase 13
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY neuropeptide Y
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RETN resistin
SELE selectin E
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SREBF1 sterol regulatory element binding transcription factor 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
USF1 upstream transcription factor 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WRN Werner syndrome, RecQ helicase-like