Anxiety Disorders Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

175 genes associated with the Anxiety Disorders phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACHE acetylcholinesterase (Yt blood group)
ACTN2 actinin, alpha 2
ADORA2A adenosine A2a receptor
ADRA2C adrenoceptor alpha 2C
ADRBK2 adrenergic, beta, receptor kinase 2
AFG3L2 AFG3-like AAA ATPase 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOE apolipoprotein E
AR androgen receptor
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASIC1 acid sensing (proton gated) ion channel 1
AUTS2 autism susceptibility candidate 2
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLINT1 clathrin interactor 1
CNR1 cannabinoid receptor 1 (brain)
CNTN5 contactin 5
CNTN6 contactin 6
COMT catechol-O-methyltransferase
CORT cortistatin
CREB1 cAMP responsive element binding protein 1
CRHR1 corticotropin releasing hormone receptor 1
CRIPT cysteine-rich PDZ-binding protein
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CTNND2 catenin (cadherin-associated protein), delta 2
CYAT1 immunoglobulin lambda light chain-like
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAOA D-amino acid oxidase activator
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DGCR6 DiGeorge syndrome critical region gene 6
DISC1 disrupted in schizophrenia 1
DLG1 discs, large homolog 1 (Drosophila)
DLG2 discs, large homolog 2 (Drosophila)
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
DTNBP1 dystrobrevin binding protein 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FKBP5 FK506 binding protein 5
FZD9 frizzled class receptor 9
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GALR1 galanin receptor 1
GALR3 galanin receptor 3
GCH1 GTP cyclohydrolase 1
GDF2 growth differentiation factor 2
GLO1 glyoxalase I
GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2, pseudogene
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRM5 glutamate receptor, metabotropic 5
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
GTF2I general transcription factor IIi
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HCRTR1 hypocretin (orexin) receptor 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTT huntingtin
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
MAT1A methionine adenosyltransferase I, alpha
MAT2A methionine adenosyltransferase II, alpha
MED12 mediator complex subunit 12
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYO3A myosin IIIA
NGF nerve growth factor (beta polypeptide)
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1
NKX2-1 NK2 homeobox 1
NLGN1 neuroligin 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS2 nitric oxide synthase 2, inducible
NPPC natriuretic peptide C
NPR3 natriuretic peptide receptor 3
NPS neuropeptide S
NPSR1 neuropeptide S receptor 1
NPY neuropeptide Y
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG3 neuregulin 3
NRXN3 neurexin 3
NSF N-ethylmaleimide-sensitive factor
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NTSR1 neurotensin receptor 1 (high affinity)
OATP1 ornithine aminotransferase pseudogene 1
OPRM1 opioid receptor, mu 1
OXTR oxytocin receptor
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAWR PRKC, apoptosis, WT1, regulator
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDE4B phosphodiesterase 4B, cAMP-specific
PENK proenkephalin
PLCB4 phospholipase C, beta 4
PLCD1 phospholipase C, delta 1
PLXNA2 plexin A2
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PRODH proline dehydrogenase (oxidase) 1
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTPRD protein tyrosine phosphatase, receptor type, D
RGS2 regulator of G-protein signaling 2
RORA RAR-related orphan receptor A
RTN4R reticulon 4 receptor
S100B S100 calcium binding protein B
SAT1 spermidine/spermine N1-acetyltransferase 1
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCT secretin
SDK1 sidekick cell adhesion molecule 1
SGCE sarcoglycan, epsilon
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC7A4 solute carrier family 7, member 4
SMOX spermine oxidase
SMS spermine synthase
SSTR5 somatostatin receptor 5
STX1A syntaxin 1A (brain)
SYNJ1 synaptojanin 1
SYNJ2 synaptojanin 2
TACR1 tachykinin receptor 1
TFIP11 tuftelin interacting protein 11
THAP1 THAP domain containing, apoptosis associated protein 1
TMPRSS9 transmembrane protease, serine 9
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TOR1A torsin family 1, member A (torsin A)
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TRH thyrotropin-releasing hormone
TSNAX translin-associated factor X
TSPO translocator protein (18kDa)
TTC1 tetratricopeptide repeat domain 1
TTR transthyretin
VIP vasoactive intestinal peptide
ZNF804A zinc finger protein 804A