Anemia Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells. (Human Disease Ontology, DOID_2355)
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Genes

84 genes associated with the Anemia phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ADD2 adducin 2 (beta)
AGTR1 angiotensin II receptor, type 1
AMPD1 adenosine monophosphate deaminase 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C20ORF194 chromosome 20 open reading frame 194
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CD36 CD36 molecule (thrombospondin receptor)
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
EPO erythropoietin
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FLT4 fms-related tyrosine kinase 4
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GSR glutathione reductase
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HBA1 hemoglobin, alpha 1
HBB hemoglobin, beta
HBS1L HBS1-like translational GTPase
HFE hemochromatosis
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HP haptoglobin
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
LEP leptin
MBL2 mannose-binding lectin (protein C) 2, soluble
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYB v-myb avian myeloblastosis viral oncogene homolog
NOS2 nitric oxide synthase 2, inducible
NR1I2 nuclear receptor subfamily 1, group I, member 2
PKLR pyruvate kinase, liver and RBC
PON1 paraoxonase 1
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SOD2 superoxide dismutase 2, mitochondrial
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase