Anemia, Sickle Cell Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Similar Terms
Downloads & Tools

Genes

121 genes associated with the Anemia, Sickle Cell phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACVRL1 activin A receptor type II-like 1
ADCY9 adenylate cyclase 9
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANXA2 annexin A2
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
AQP1 aquaporin 1 (Colton blood group)
ARG1 arginase 1
ARG2 arginase 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BMP4 bone morphogenetic protein 4
BMP6 bone morphogenetic protein 6
BMPR1A bone morphogenetic protein receptor, type IA
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD36 CD36 molecule (thrombospondin receptor)
CD40LG CD40 ligand
CD81 CD81 molecule
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DRD2 dopamine receptor D2
EDN1 endothelin 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPT1 ethanolaminephosphotransferase 1
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
G6PD glucose-6-phosphate dehydrogenase
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13
GCH1 GTP cyclohydrolase 1
GOLGB1 golgin B1
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPM6B glycoprotein M6B
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HBA1 hemoglobin, alpha 1
HBB hemoglobin, beta
HBBP1 hemoglobin, beta pseudogene 1
HBE1 hemoglobin, epsilon 1
HBG2 hemoglobin, gamma G
HBS1L HBS1-like translational GTPase
HFE hemochromatosis
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HP haptoglobin
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IL4R interleukin 4 receptor
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNK6 potassium channel, two pore domain subfamily K, member 6
KL klotho
KLF1 Kruppel-like factor 1 (erythroid)
KLF10 Kruppel-like factor 10
LDLR low density lipoprotein receptor
MBL2 mannose-binding lectin (protein C) 2, soluble
MIR4301 microRNA 4301
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
OR51B5 olfactory receptor, family 51, subfamily B, member 5
OR51B6 olfactory receptor, family 51, subfamily B, member 6
RHCE Rh blood group, CcEe antigens
RHOG ras homolog family member G
SAR1A secretion associated, Ras related GTPase 1A
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SMAD3 SMAD family member 3
SMAD6 SMAD family member 6
SOD2 superoxide dismutase 2, mitochondrial
TEK TEK tyrosine kinase, endothelial
TGFB1 transforming growth factor, beta 1
TGFBR3 transforming growth factor, beta receptor III
THBD thrombomodulin
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOX thymocyte selection-associated high mobility group box
TRIM21 tripartite motif containing 21
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A