Anemia, Macrocytic Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D000748
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Genes

199 genes/proteins associated with the disease Anemia, Macrocytic from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.59172
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.57186
CCND3 cyclin D3 1.5311
CCND2 cyclin D2 1.51155
BCL2L1 BCL2-like 1 1.48505
GSTP1 glutathione S-transferase pi 1 1.47736
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.47115
ALB albumin 1.44544
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.44327
PCNA proliferating cell nuclear antigen 1.44246
IL6 interleukin 6 1.43428
TP53 tumor protein p53 1.42183
CAT catalase 1.41775
DDIT3 DNA-damage-inducible transcript 3 1.41257
TNF tumor necrosis factor 1.39591
TYMP thymidine phosphorylase 1.36104
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.35877
FOS FBJ murine osteosarcoma viral oncogene homolog 1.35647
ASS1 argininosuccinate synthase 1 1.34694
GADD45A growth arrest and DNA-damage-inducible, alpha 1.33966
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.33791
DCN decorin 1.32044
FNDC3B fibronectin type III domain containing 3B 1.3039
KLF4 Kruppel-like factor 4 (gut) 1.30056
G0S2 G0/G1 switch 2 1.29875
ERCC1 excision repair cross-complementation group 1 1.29875
ILF3 interleukin enhancer binding factor 3, 90kDa 1.29564
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.28672
ODC1 ornithine decarboxylase 1 1.27936
CCND1 cyclin D1 1.27751
PIWIL2 piwi-like RNA-mediated gene silencing 2 1.27689
MXI1 MAX interactor 1, dimerization protein 1.27316
CCNC cyclin C 1.26638
CCNA2 cyclin A2 1.25463
IFNG interferon, gamma 1.24935
BCL2 B-cell CLL/lymphoma 2 1.24874
S100A8 S100 calcium binding protein A8 1.24874
IFITM1 interferon induced transmembrane protein 1 1.24307
SLC30A9 solute carrier family 30 (zinc transporter), member 9 1.23201
CCL2 chemokine (C-C motif) ligand 2 1.22501
PTCH1 patched 1 1.22242
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 1.21695
AHNAK AHNAK nucleoprotein 1.21141
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.20881
COL6A3 collagen, type VI, alpha 3 1.2059
TRIB3 tribbles pseudokinase 3 1.20558
MAPK1 mitogen-activated protein kinase 1 1.2046
CPT1A carnitine palmitoyltransferase 1A (liver) 1.19933
LEF1 lymphoid enhancer-binding factor 1 1.19835
LAMC2 laminin, gamma 2 1.19574
CD44 CD44 molecule (Indian blood group) 1.19509
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 1.19345
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 1.19014
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 1.18816
COL1A2 collagen, type I, alpha 2 1.1862
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) 1.18359
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 1.17794
AQP9 aquaporin 9 1.17629
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 1.17202
CD83 CD83 molecule 1.16733
NOS2 nitric oxide synthase 2, inducible 1.16533
TOP1 topoisomerase (DNA) I 1.165
WNT10A wingless-type MMTV integration site family, member 10A 1.16104
MAGED1 melanoma antigen family D1 1.16035
FAS Fas cell surface death receptor 1.15627
ARF3 ADP-ribosylation factor 3 1.1556
TK2 thymidine kinase 2, mitochondrial 1.15055
HSPA8 heat shock 70kDa protein 8 1.14954
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.1461
MARS methionyl-tRNA synthetase 1.14098
CUL4A cullin 4A 1.1403
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 1.13621
SRSF11 serine/arginine-rich splicing factor 11 1.13518
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 1.13518
UQCRB ubiquinol-cytochrome c reductase binding protein 1.13143
FADS2 fatty acid desaturase 2 1.12872
SFXN4 sideroflexin 4 1.12668
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.12599
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.12357
OPA1 optic atrophy 1 (autosomal dominant) 1.12254
MMP2 matrix metallopeptidase 2 1.12185
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.12185
RBM14 RNA binding motif protein 14 1.12151
ATF2 activating transcription factor 2 1.12117
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.12082
MPZL1 myelin protein zero-like 1 1.11775
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 1.11741
NAMPT nicotinamide phosphoribosyltransferase 1.11606
FASN fatty acid synthase 1.11536
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 1.11396
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.11396
HSPA1A heat shock 70kDa protein 1A 1.11396
GSTA1 glutathione S-transferase alpha 1 1.11325
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 1.11325
CTBP2 C-terminal binding protein 2 1.1129
GPX4 glutathione peroxidase 4 1.11116
IFI6 interferon, alpha-inducible protein 6 1.10942
PRDM1 PR domain containing 1, with ZNF domain 1.10942
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.10942
PARD3 par-3 family cell polarity regulator 1.10907
IL1B interleukin 1, beta 1.10562
HMGB1 high mobility group box 1 1.10562
DAP3 death associated protein 3 1.10527
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.10527
ACTA2 actin, alpha 2, smooth muscle, aorta 1.10493
CCNE2 cyclin E2 1.10388
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 1.10353
COX6C cytochrome c oxidase subunit VIc 1.10211
YARS tyrosyl-tRNA synthetase 1.10175
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 1.10175
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 1.09751
RRBP1 ribosome binding protein 1 1.09681
DHFR dihydrofolate reductase 1.09541
GCLM glutamate-cysteine ligase, modifier subunit 1.09297
MAPK3 mitogen-activated protein kinase 3 1.08726
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 1.08584
ATF3 activating transcription factor 3 1.08584
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 1.0784
FNBP1 formin binding protein 1 1.0784
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.07804
RIPK2 receptor-interacting serine-threonine kinase 2 1.07732
SOAT1 sterol O-acyltransferase 1 1.07589
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.07553
GPX1 glutathione peroxidase 1 1.07057
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.07057
RARA retinoic acid receptor, alpha 1.07022
UQCRC1 ubiquinol-cytochrome c reductase core protein I 1.06917
CARS cysteinyl-tRNA synthetase 1.06917
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.06881
CLCN3 chloride channel, voltage-sensitive 3 1.06625
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.06625
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 1.06515
APOB apolipoprotein B 1.06442
CCNG1 cyclin G1 1.06333
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.06008
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.06008
FAM129A family with sequence similarity 129, member A 1.05936
EMP3 epithelial membrane protein 3 1.05864
NFE2L2 nuclear factor, erythroid 2-like 2 1.05864
HYOU1 hypoxia up-regulated 1 1.05573
ZBTB20 zinc finger and BTB domain containing 20 1.052
TIMP1 TIMP metallopeptidase inhibitor 1 1.05163
AFP alpha-fetoprotein 1.05126
IRF9 interferon regulatory factor 9 1.05015
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.04941
HDAC2 histone deacetylase 2 1.04941
RAMP1 receptor (G protein-coupled) activity modifying protein 1 1.04904
GPX3 glutathione peroxidase 3 1.04904
IL1RN interleukin 1 receptor antagonist 1.04904
HSPA1B heat shock 70kDa protein 1B 1.04794
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.04721
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 1.04647
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.04501
HMOX1 heme oxygenase 1 1.04427
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 1.04314
IER5 immediate early response 5 1.04276
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 1.04239
PLSCR1 phospholipid scramblase 1 1.04014
BTG3 BTG family, member 3 1.03789
CSNK1A1 casein kinase 1, alpha 1 1.03715
TBXAS1 thromboxane A synthase 1 (platelet) 1.03493
SLC16A6 solute carrier family 16, member 6 1.03419
RBBP4 retinoblastoma binding protein 4 1.03382
BAX BCL2-associated X protein 1.03271
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.03197
NINJ1 ninjurin 1 1.03197
GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.03197
CTSB cathepsin B 1.03159
TGFB1 transforming growth factor, beta 1 1.03159
PROCR protein C receptor, endothelial 1.03122
BTG2 BTG family, member 2 1.03046
MGMT O-6-methylguanine-DNA methyltransferase 1.03046
CHEK1 checkpoint kinase 1 1.03009
XPC xeroderma pigmentosum, complementation group C 1.02933
WARS tryptophanyl-tRNA synthetase 1.02933
IGF2R insulin-like growth factor 2 receptor 1.02858
CD63 CD63 molecule 1.02821
ACTB actin, beta 1.02746
COL1A1 collagen, type I, alpha 1 1.02596
PEBP1 phosphatidylethanolamine binding protein 1 1.02559
VCAM1 vascular cell adhesion molecule 1 1.02447
SLC35A4 solute carrier family 35, member A4 1.02373
SMOX spermine oxidase 1.02262
GALC galactosylceramidase 1.02151
IGF1R insulin-like growth factor 1 receptor 1.02114
TIMP2 TIMP metallopeptidase inhibitor 2 1.0204
ADD3 adducin 3 (gamma) 1.02003
POSTN periostin, osteoblast specific factor 1.02003
MMP3 matrix metallopeptidase 3 1.01928
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 1.01776
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 1.01512
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 1.01361
IFNGR1 interferon gamma receptor 1 1.01324
TNNI3 troponin I type 3 (cardiac) 1.01286
TSPAN14 tetraspanin 14 1.01249
NR2F2 nuclear receptor subfamily 2, group F, member 2 1.01249
NCL nucleolin 1.01249
CRAT carnitine O-acetyltransferase 1.01025
NR5A2 nuclear receptor subfamily 5, group A, member 2 1.01025