Amyotrophic Lateral Sclerosis Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. (Human Disease Ontology, DOID_332)
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Genes

76 genes associated with the trait Amyotrophic Lateral Sclerosis in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
UNC13A unc-13 homolog A (C. elegans) 1.15755
CDC42 cell division cycle 42 0.818237
KIFAP3 kinesin-associated protein 3 0.731179
TIAM1 T-cell lymphoma invasion and metastasis 1 0.711358
DPP6 dipeptidyl-peptidase 6 0.685324
C9ORF72 chromosome 9 open reading frame 72 0.406869
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.406869
ATXN1 ataxin 1 0.378873
SELL selectin L 0.378873
ZFP64 ZFP64 zinc finger protein 0.356676
SUSD1 sushi domain containing 1 0.33862
OR52K3P olfactory receptor, family 52, subfamily K, member 3 pseudogene 0.323533
CNTN4 contactin 4 0.323533
MORN2 MORN repeat containing 2 0.310838
DISC1 disrupted in schizophrenia 1 0.310838
NT5C1A 5'-nucleotidase, cytosolic IA 0.310838
SLC39A11 solute carrier family 39, member 11 0.310838
LIPC lipase, hepatic 0.29992
FHDC1 FH2 domain containing 1 0.29992
CHAMP1 chromosome alignment maintaining phosphoprotein 1 0.285978
BTBD11 BTB (POZ) domain containing 11 0.241613
SHROOM3 shroom family member 3 0.225557
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.222515
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.214602
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.195671
INTS4 integrator complex subunit 4 0.180407
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.179351
ARSG arylsulfatase G 0.172311
PDE4B phosphodiesterase 4B, cAMP-specific 0.167921
TCEA1 transcription elongation factor A (SII), 1 0.14851
RNF14 ring finger protein 14 0.140513
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 0.140407
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.138172
FMN2 formin 2 0.133432
RNF144A ring finger protein 144A 0.133383
DMD dystrophin 0.126204
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.12321
AGBL4 ATP/GTP binding protein-like 4 0.120366
POF1B premature ovarian failure, 1B 0.115078
GUCD1 guanylyl cyclase domain containing 1 0.111861
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.109301
CD1E CD1e molecule 0.100203
NKRF NFKB repressing factor 0.099297
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.095353
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.084601
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 0.082851
RBMS2 RNA binding motif, single stranded interacting protein 2 0.080426
GRIK2 glutamate receptor, ionotropic, kainate 2 0.078441
CDC5L cell division cycle 5-like 0.070937
ZNF385B zinc finger protein 385B 0.068894
MPZL1 myelin protein zero-like 1 0.063957
STAG2 stromal antigen 2 0.057943
SHB Src homology 2 domain containing adaptor protein B 0.053158
PDE10A phosphodiesterase 10A 0.043872
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.040043
NCAM2 neural cell adhesion molecule 2 0.03808
CYP1B1-AS1 CYP1B1 antisense RNA 1 0.036156
SPTB spectrin, beta, erythrocytic 0.035856
MECOM MDS1 and EVI1 complex locus 0.035527
KIAA0586 KIAA0586 0.03345
RD3 retinal degeneration 3 0.030327
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 0.029332
ELF5 E74-like factor 5 (ets domain transcription factor) 0.029039
BCAS1 breast carcinoma amplified sequence 1 0.027821
LAMA2 laminin, alpha 2 0.026808
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.026573
SSPO SCO-spondin 0.026219
RUFY1 RUN and FYVE domain containing 1 0.025958
PEX11A peroxisomal biogenesis factor 11 alpha 0.025194
WDR93 WD repeat domain 93 0.025194
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.025049
MYLIP myosin regulatory light chain interacting protein 0.024895
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.024803
AKAP13 A kinase (PRKA) anchor protein 13 0.024408
KCNIP4 Kv channel interacting protein 4 0.024179
OTOA otoancorin 0.023489