Amyotrophic Lateral Sclerosis Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. (Human Disease Ontology, DOID_332)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D000690
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Genes

80 genes/proteins associated with the disease Amyotrophic Lateral Sclerosis from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
SOD1 superoxide dismutase 1, soluble 2.88009
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.88009
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.88009
TP53 tumor protein p53 2.88009
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.88009
TARDBP TAR DNA binding protein 2.88009
GSTP1 glutathione S-transferase pi 1 2.88009
CHMP2B charged multivesicular body protein 2B 2.88009
SIGMAR1 sigma non-opioid intracellular receptor 1 2.88009
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.88009
GFAP glial fibrillary acidic protein 2.88009
UNC13A unc-13 homolog A (C. elegans) 2.88009
DPP6 dipeptidyl-peptidase 6 2.88009
SOD2 superoxide dismutase 2, mitochondrial 2.88009
DBR1 debranching RNA lariats 1 2.88009
SQSTM1 sequestosome 1 2.88009
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 2.88009
CD40LG CD40 ligand 2.88009
GSR glutathione reductase 2.88009
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.88009
TNF tumor necrosis factor 1.73918
IL2 interleukin 2 1.62557
NOS2 nitric oxide synthase 2, inducible 1.6249
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.58607
APP amyloid beta (A4) precursor protein 1.55059
IL1B interleukin 1, beta 1.54669
LHB luteinizing hormone beta polypeptide 1.47556
CAT catalase 1.47348
FOS FBJ murine osteosarcoma viral oncogene homolog 1.46225
DRD2 dopamine receptor D2 1.45326
NOS1 nitric oxide synthase 1 (neuronal) 1.44572
MAPK3 mitogen-activated protein kinase 3 1.443
VEGFA vascular endothelial growth factor A 1.43892
JUN jun proto-oncogene 1.43809
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.3759
BAX BCL2-associated X protein 1.37561
MAPK1 mitogen-activated protein kinase 1 1.34869
PRL prolactin 1.3484
IL6 interleukin 6 1.34459
GPX1 glutathione peroxidase 1 1.31357
IFNG interferon, gamma 1.30087
HMOX1 heme oxygenase 1 1.29996
GSK3B glycogen synthase kinase 3 beta 1.2975
MMP2 matrix metallopeptidase 2 1.29011
BCL2 B-cell CLL/lymphoma 2 1.22853
TF transferrin 1.22696
NFE2L2 nuclear factor, erythroid 2-like 2 1.20719
IGF1 insulin-like growth factor 1 (somatomedin C) 1.20295
BDNF brain-derived neurotrophic factor 1.20196
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.19542
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.18783
CCL2 chemokine (C-C motif) ligand 2 1.16866
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.16368
MAPK8 mitogen-activated protein kinase 8 1.16236
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.15695
CCND1 cyclin D1 1.13313
TH tyrosine hydroxylase 1.12426
CYCS cytochrome c, somatic 1.12219
DRD1 dopamine receptor D1 1.11707
MAPK9 mitogen-activated protein kinase 9 1.10665
IL6ST interleukin 6 signal transducer 1.09541
ATF3 activating transcription factor 3 1.08726
DDIT3 DNA-damage-inducible transcript 3 1.07804
ALB albumin 1.07768
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.07447
PRKCD protein kinase C, delta 1.07234
CREB1 cAMP responsive element binding protein 1 1.07022
TSHB thyroid stimulating hormone, beta 1.06734
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.06188
TGFB1 transforming growth factor, beta 1 1.06152
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.05163
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.05052
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.04276
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.04201
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.04088
F2R coagulation factor II (thrombin) receptor 1.04051
TJP1 tight junction protein 1 1.02373
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.01474
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.01361
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.01212