Alopecia Areata Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A hypersensitivity reaction type II disease resulting in the loss of hair on the scalp and elsewhere on the body initially causing bald spots. (Human Disease Ontology, DOID_986)
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49 genes associated with the Alopecia Areata phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
C5 complement component 5
CCL2 chemokine (C-C motif) ligand 2
CLEC16A C-type lectin domain family 16, member A
CTLA4 cytotoxic T-lymphocyte-associated protein 4
ERBB3 erb-b2 receptor tyrosine kinase 3
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCRL3 Fc receptor-like 3
FLG filaggrin
FOXP3 forkhead box P3
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPA1B heat shock 70kDa protein 1B
ICOSLG inducible T-cell co-stimulator ligand
IFNG interferon, gamma
IKZF4 IKAROS family zinc finger 4 (Eos)
IL10 interleukin 10
IL12B interleukin 12B
IL13 interleukin 13
IL16 interleukin 16
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL2RA interleukin 2 receptor, alpha
IL36RN interleukin 36 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH4 notch 4
PRDX5 peroxiredoxin 5
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAET1L retinoic acid early transcript 1L
SPATA5 spermatogenesis associated 5
STX17 syntaxin 17
TNF tumor necrosis factor
TRAF1 TNF receptor-associated factor 1
ULBP3 UL16 binding protein 3
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor