Age-related macular degeneration Gene Set

Dataset GWAS Catalog SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision. (Human Disease Ontology, DOID_10871)
External Link https://www.ebi.ac.uk/gwas/search?query=Age-related macular degeneration
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Genes

26 genes associated with the Age-related macular degeneration phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
ARMS2 age-related maculopathy susceptibility 2 3.37239
CFH complement factor H 3.10399
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 1.82114
HTRA1 HtrA serine peptidase 1 1.64179
C3 complement component 3 1.44511
CFB complement factor B 1.29433
APOC1 apolipoprotein C-I 1.04952
CETP cholesteryl ester transfer protein, plasma 0.870394
COL8A1 collagen, type VIII, alpha 1 0.734471
LOC102724766 uncharacterized LOC102724766 0.686534
NOTCH4 notch 4 0.637972
TGFBR1 transforming growth factor, beta receptor 1 0.626595
CCDC109B coiled-coil domain containing 109B 0.602611
RAD51B RAD51 paralog B 0.595536
TNXB tenascin XB 0.522843
ADAMTS9-AS2 ADAMTS9 antisense RNA 2 0.463473
FRK fyn-related Src family tyrosine kinase 0.434785
B3GALTL beta 1,3-galactosyltransferase-like 0.405958
REST RE1-silencing transcription factor 0.405958
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.351407
PLA2G12A phospholipase A2, group XIIA 0.295129
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.220915
RREB1 ras responsive element binding protein 1 0.220915
TYR tyrosinase 0.104568
CLIC5 chloride intracellular channel 5 0.048624
GLI3 GLI family zinc finger 3 0.042592