Acute Lung Injury Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Acute lung injury (ALI) is a diffuse heterogeneous lung injury characterized by hypoxemia, non cardiogenic pulmonary edema, low lung compliance and widespread capillary leakage. ALI is caused by any stimulus of local or systemic inflammation, principally sepsis. (Experimental Factor Ontology, EFO_0004610)
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Genes

37 genes associated with the Acute Lung Injury phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ANGPT2 angiopoietin 2
APOA1 apolipoprotein A-I
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
DIO2 deiodinase, iodothyronine, type II
FAAH fatty acid amide hydrolase
FAS Fas cell surface death receptor
FLT1 fms-related tyrosine kinase 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
IL10 interleukin 10
IL18 interleukin 18
IL6 interleukin 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
MBL2 mannose-binding lectin (protein C) 2, soluble
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYD88 myeloid differentiation primary response 88
NAMPT nicotinamide phosphoribosyltransferase
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
POPDC3 popeye domain containing 3
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PRDX6 peroxiredoxin 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPB surfactant protein B
SOD3 superoxide dismutase 3, extracellular
SUFU suppressor of fused homolog (Drosophila)
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TNF tumor necrosis factor
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
VEGFA vascular endothelial growth factor A