Acute Disease Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

326 genes associated with the Acute Disease phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACTA1 actin, alpha 1, skeletal muscle
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2C adrenoceptor alpha 2C
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOE apolipoprotein E
ARHGAP26 Rho GTPase activating protein 26
ASXL1 additional sex combs like transcriptional regulator 1
ATM ATM serine/threonine kinase
BCOR BCL6 corepressor
BCORL1 BCL6 corepressor-like 1
BPI bactericidal/permeability-increasing protein
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
CARD11 caspase recruitment domain family, member 11
CAT catalase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL4L2 chemokine (C-C motif) ligand 4-like 2
CCL5 chemokine (C-C motif) ligand 5
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD28 CD28 molecule
CD72 CD72 molecule
CD86 CD86 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CETP cholesteryl ester transfer protein, plasma
CFI complement factor I
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHIT1 chitinase 1 (chitotriosidase)
CHRM1 cholinergic receptor, muscarinic 1
CIITA class II, major histocompatibility complex, transactivator
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSC cathepsin C
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYSLTR1 cysteinyl leukotriene receptor 1
DAGLB diacylglycerol lipase, beta
DCK deoxycytidine kinase
DISC1 disrupted in schizophrenia 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOK2 docking protein 2, 56kDa
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRP2 dystrophin related protein 2
EDN1 endothelin 1
EGLN1 egl-9 family hypoxia-inducible factor 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC5 excision repair cross-complementation group 5
ESR1 estrogen receptor 1
ETV6 ets variant 6
F12 coagulation factor XII (Hageman factor)
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAS Fas cell surface death receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FLT3 fms-related tyrosine kinase 3
FOXO1 forkhead box O1
FOXP3 forkhead box P3
FTO fat mass and obesity associated
G6PD glucose-6-phosphate dehydrogenase
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GAN gigaxonin
GATA1 GATA binding protein 1 (globin transcription factor 1)
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA4 gap junction protein, alpha 4, 37kDa
GLRA1 glycine receptor, alpha 1
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP6 glycoprotein VI (platelet)
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HABP2 hyaluronan binding protein 2
HFE hemochromatosis
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNA1 interferon, alpha 1
IFNG interferon, gamma
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFNL3 interferon, lambda 3
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12B interleukin 12B
IL12RB2 interleukin 12 receptor, beta 2
IL17A interleukin 17A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL23R interleukin 23 receptor
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
IL7R interleukin 7 receptor
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRF1 interferon regulatory factor 1
IRF8 interferon regulatory factor 8
IRS1 insulin receptor substrate 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK2 Janus kinase 2
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DP1 killer cell immunoglobulin-like receptor, two domains, pseudogene 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LCT lactase
LEP leptin
LIPG lipase, endothelial
LPL lipoprotein lipase
LTA lymphotoxin alpha
LTC4S leukotriene C4 synthase
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAOA monoamine oxidase A
MBL2 mannose-binding lectin (protein C) 2, soluble
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MGMT O-6-methylguanine-DNA methyltransferase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR182 microRNA 182
MIR196A2 microRNA 196a-2
MIR27A microRNA 27a
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYO9B myosin IXB
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBN nibrin
NCF4 neutrophil cytosolic factor 4, 40kDa
NEFM neurofilament, medium polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOD2 nucleotide-binding oligomerization domain containing 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX3 NADPH oxidase 3
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PARD3 par-3 family cell polarity regulator
PARP1 poly (ADP-ribose) polymerase 1
PAX4 paired box 4
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAT plasminogen activator, tissue
PML promyelocytic leukemia
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PRSS1 protease, serine, 1 (trypsin 1)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGDR prostaglandin D2 receptor (DP)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RFC1 replication factor C (activator 1) 1, 145kDa
RGS2 regulator of G-protein signaling 2
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELE selectin E
SELL selectin L
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMN1 survival of motor neuron 1, telomeric
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SPINK1 serine peptidase inhibitor, Kazal type 1
ST2 suppression of tumorigenicity 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAC1 tachykinin, precursor 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBXA2R thromboxane A2 receptor
TET2 tet methylcytosine dioxygenase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TLX1 T-cell leukemia homeobox 1
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TP53 tumor protein p53
TPH1 tryptophan hydroxylase 1
TPMT thiopurine S-methyltransferase
TRAF5 TNF receptor-associated factor 5
TYMS thymidylate synthetase
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WRN Werner syndrome, RecQ helicase-like
WT1 Wilms tumor 1
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZNF429 zinc finger protein 429