ARHGEF25 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description Rho guanine nucleotide exchange factor (GEF) 25|Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 115557)
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7 interacting proteins for ARHGEF25 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
CDC42 cell division cycle 42
PRKCG protein kinase C, gamma
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
SMAD1 SMAD family member 1