AH-6809-7049 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the AH-6809-7049 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACKR3 atypical chemokine receptor 3
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AHSP alpha hemoglobin stabilizing protein
ALPK1 alpha-kinase 1
ARHGAP26 Rho GTPase activating protein 26
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
CCL27 chemokine (C-C motif) ligand 27
CD70 CD70 molecule
CDC14A cell division cycle 14A
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CTNND2 catenin (cadherin-associated protein), delta 2
CTSF cathepsin F
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DGCR8 DGCR8 microprocessor complex subunit
DOHH deoxyhypusine hydroxylase/monooxygenase
DSPP dentin sialophosphoprotein
DST dystonin
EIF1 eukaryotic translation initiation factor 1
ELF4 E74-like factor 4 (ets domain transcription factor)
ESR1 estrogen receptor 1
FAM13A family with sequence similarity 13, member A
FBXL15 F-box and leucine-rich repeat protein 15
FH fumarate hydratase
FRS3 fibroblast growth factor receptor substrate 3
FSD1 fibronectin type III and SPRY domain containing 1
FYB FYN binding protein
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAS7 growth arrest-specific 7
ING1 inhibitor of growth family, member 1
ING4 inhibitor of growth family, member 4
KCTD13 potassium channel tetramerization domain containing 13
KIAA1644 KIAA1644
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMK1 LIM domain kinase 1
LIN7B lin-7 homolog B (C. elegans)
LPPR2 lipid phosphate phosphatase-related protein type 2
LRRC6 leucine rich repeat containing 6
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LRRN2 leucine rich repeat neuronal 2
MANBA mannosidase, beta A, lysosomal
MAP1A microtubule-associated protein 1A
MECP2 methyl CpG binding protein 2
METTL5 methyltransferase like 5
MFSD11 major facilitator superfamily domain containing 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MUC1 mucin 1, cell surface associated
MUC3B mucin 3B, cell surface associated
NID2 nidogen 2 (osteonidogen)
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NT5M 5',3'-nucleotidase, mitochondrial
PCGF3 polycomb group ring finger 3
PDGFB platelet-derived growth factor beta polypeptide
PEX26 peroxisomal biogenesis factor 26
PEX6 peroxisomal biogenesis factor 6
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLXND1 plexin D1
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRPH peripherin
PTCH1 patched 1
PWAR5 Prader Willi/Angelman region RNA 5
RAB40B RAB40B, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBKS ribokinase
REEP1 receptor accessory protein 1
RGS14 regulator of G-protein signaling 14
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAMD4A sterile alpha motif domain containing 4A
SARM1 sterile alpha and TIR motif containing 1
SCEL sciellin
SCNN1B sodium channel, non voltage gated 1 beta subunit
SDHAF1 succinate dehydrogenase complex assembly factor 1
SETBP1 SET binding protein 1
SGSM2 small G protein signaling modulator 2
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SMG5 SMG5 nonsense mediated mRNA decay factor
SMIM8 small integral membrane protein 8
SNW1 SNW domain containing 1
STK17B serine/threonine kinase 17b
STK4 serine/threonine kinase 4
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TCTN2 tectonic family member 2
THRAP3 thyroid hormone receptor associated protein 3
TIMELESS timeless circadian clock
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRIM10 tripartite motif containing 10
TUBA4B tubulin, alpha 4b
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VGF VGF nerve growth factor inducible
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZBTB22 zinc finger and BTB domain containing 22
ZNF37BP zinc finger protein 37B, pseudogene
ZNF444 zinc finger protein 444
ZNF667 zinc finger protein 667

decreased expression

Symbol Name
AIM1L absent in melanoma 1-like
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARRB2 arrestin, beta 2
BBS7 Bardet-Biedl syndrome 7
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
C11ORF63 chromosome 11 open reading frame 63
C14ORF93 chromosome 14 open reading frame 93
C1R complement component 1, r subcomponent
CCDC7 coiled-coil domain containing 7
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK3 cyclin-dependent kinase 3
CENPJ centromere protein J
CEP97 centrosomal protein 97kDa
CFAP44 cilia and flagella associated protein 44
CFAP69 cilia and flagella associated protein 69
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CRIP2 cysteine-rich protein 2
CUEDC1 CUE domain containing 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCLRE1A DNA cross-link repair 1A
DENND5B DENN/MADD domain containing 5B
DOK5 docking protein 5
DSCAM Down syndrome cell adhesion molecule
EDIL3 EGF-like repeats and discoidin I-like domains 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA3 ephrin-A3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ERF Ets2 repressor factor
FAM131B family with sequence similarity 131, member B
FAM188A family with sequence similarity 188, member A
FUZ fuzzy planar cell polarity protein
GEMIN8 gem (nuclear organelle) associated protein 8
GJC1 gap junction protein, gamma 1, 45kDa
GLB1L galactosidase, beta 1-like
GMEB1 glucocorticoid modulatory element binding protein 1
GPR157 G protein-coupled receptor 157
GRB7 growth factor receptor-bound protein 7
GREB1L growth regulation by estrogen in breast cancer-like
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST2H2AA3 histone cluster 2, H2aa3
HPS6 Hermansky-Pudlak syndrome 6
HSPA1L heat shock 70kDa protein 1-like
KLHL25 kelch-like family member 25
KRT86 keratin 86, type II
LIG4 ligase IV, DNA, ATP-dependent
LMAN1 lectin, mannose-binding, 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MAGEF1 melanoma antigen family F1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MFSD6 major facilitator superfamily domain containing 6
MILR1 mast cell immunoglobulin-like receptor 1
MPDU1 mannose-P-dolichol utilization defect 1
MRPL28 mitochondrial ribosomal protein L28
MTERF4 mitochondrial transcription termination factor 4
MTMR11 myotubularin related protein 11
NOL12 nucleolar protein 12
NT5C 5', 3'-nucleotidase, cytosolic
OCLN occludin
OSMR oncostatin M receptor
PAQR4 progestin and adipoQ receptor family member IV
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PRAME preferentially expressed antigen in melanoma
PRKCD protein kinase C, delta
PSENEN presenilin enhancer gamma secretase subunit
PTPRU protein tyrosine phosphatase, receptor type, U
RAD54L2 RAD54-like 2 (S. cerevisiae)
RGS17 regulator of G-protein signaling 17
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF122 ring finger protein 122
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RUNX1-IT1 RUNX1 intronic transcript 1
S100A3 S100 calcium binding protein A3
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SMAD7 SMAD family member 7
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SOBP sine oculis binding protein homolog (Drosophila)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STIM1 stromal interaction molecule 1
SYTL2 synaptotagmin-like 2
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TM6SF1 transmembrane 6 superfamily member 1
TM7SF2 transmembrane 7 superfamily member 2
TUBG2 tubulin, gamma 2
UNC119 unc-119 homolog (C. elegans)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZNF225 zinc finger protein 225
ZNF675 zinc finger protein 675