AG-028671-6587 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the AG-028671-6587 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ACTB actin, beta
AHI1 Abelson helper integration site 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
APP amyloid beta (A4) precursor protein
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATP13A3 ATPase type 13A3
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF62 chromosome 6 open reading frame 62
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDV3 CDV3 homolog (mouse)
CFLAR CASP8 and FADD-like apoptosis regulator
CREB1 cAMP responsive element binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DAPK3 death-associated protein kinase 3
DAZAP2 DAZ associated protein 2
DLG1 discs, large homolog 1 (Drosophila)
DTNA dystrobrevin, alpha
DUSP1 dual specificity phosphatase 1
EIF5A eukaryotic translation initiation factor 5A
ELMO2 engulfment and cell motility 2
EXOC5 exocyst complex component 5
FAS Fas cell surface death receptor
FNTB farnesyltransferase, CAAX box, beta
FOLR1 folate receptor 1 (adult)
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GDAP1 ganglioside induced differentiation associated protein 1
GLE1 GLE1 RNA export mediator
GLS2 glutaminase 2 (liver, mitochondrial)
GLUD2 glutamate dehydrogenase 2
GNS glucosamine (N-acetyl)-6-sulfatase
GPR87 G protein-coupled receptor 87
GTF2I general transcription factor IIi
HIST1H2AJ histone cluster 1, H2aj
HN1L hematological and neurological expressed 1-like
HSPA4 heat shock 70kDa protein 4
HTATSF1 HIV-1 Tat specific factor 1
ITCH itchy E3 ubiquitin protein ligase
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
KIF22 kinesin family member 22
KLF9 Kruppel-like factor 9
LAMP1 lysosomal-associated membrane protein 1
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
NFYA nuclear transcription factor Y, alpha
NPIPB3 nuclear pore complex interacting protein family, member B3
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUMA1 nuclear mitotic apparatus protein 1
PAPOLA poly(A) polymerase alpha
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PICALM phosphatidylinositol binding clathrin assembly protein
PKP3 plakophilin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRLR prolactin receptor
PRUNE prune exopolyphosphatase
PTBP1 polypyrimidine tract binding protein 1
RAB35 RAB35, member RAS oncogene family
RALB v-ral simian leukemia viral oncogene homolog B
RBM5 RNA binding motif protein 5
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SCAMP1 secretory carrier membrane protein 1
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SS18 synovial sarcoma translocation, chromosome 18
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STIP1 stress-induced phosphoprotein 1
STX16 syntaxin 16
SUGP1 SURP and G patch domain containing 1
SYTL2 synaptotagmin-like 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCAF1 TRPM8 channel-associated factor 1
TFG TRK-fused gene
TMEM230 transmembrane protein 230
TMEM259 transmembrane protein 259
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOX4 TOX high mobility group box family member 4
TPM1 tropomyosin 1 (alpha)
TRAF4 TNF receptor-associated factor 4
TUBGCP2 tubulin, gamma complex associated protein 2
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
UBOX5 U-box domain containing 5
USP34 ubiquitin specific peptidase 34
VAMP3 vesicle-associated membrane protein 3
VLDLR very low density lipoprotein receptor
ZNF205 zinc finger protein 205
ZNF552 zinc finger protein 552

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADM adrenomedullin
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGAP10 Rho GTPase activating protein 10
AXIN1 axin 1
C1ORF159 chromosome 1 open reading frame 159
C6ORF47 chromosome 6 open reading frame 47
C8ORF44 chromosome 8 open reading frame 44
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCDC69 coiled-coil domain containing 69
CCDC88C coiled-coil domain containing 88C
CD3EAP CD3e molecule, epsilon associated protein
CDR2L cerebellar degeneration-related protein 2-like
CENPB centromere protein B, 80kDa
CEP72 centrosomal protein 72kDa
CHEK2 checkpoint kinase 2
CHML choroideremia-like (Rab escort protein 2)
CLCN2 chloride channel, voltage-sensitive 2
CLCN6 chloride channel, voltage-sensitive 6
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRYBG3 beta-gamma crystallin domain containing 3
CST6 cystatin E/M
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERN2 endoplasmic reticulum to nucleus signaling 2
EXO5 exonuclease 5
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM184A family with sequence similarity 184, member A
FAN1 FANCD2/FANCI-associated nuclease 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRTP1 growth hormone regulated TBC protein 1
GRWD1 glutamate-rich WD repeat containing 1
GSTTP1 glutathione S-transferase theta pseudogene 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTPBP6 GTP binding protein 6 (putative)
HAMP hepcidin antimicrobial peptide
HDAC11 histone deacetylase 11
HPN hepsin
INPPL1 inositol polyphosphate phosphatase-like 1
IQCC IQ motif containing C
KLC2 kinesin light chain 2
KRT8P12 keratin 8 pseudogene 12
MAPKBP1 mitogen-activated protein kinase binding protein 1
MFAP2 microfibrillar-associated protein 2
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MYBBP1A MYB binding protein (P160) 1a
NKRF NFKB repressing factor
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NPFFR1 neuropeptide FF receptor 1
NRSN2 neurensin 2
NT5DC3 5'-nucleotidase domain containing 3
OGFRL1 opioid growth factor receptor-like 1
PC pyruvate carboxylase
PELI1 pellino E3 ubiquitin protein ligase 1
PELP1 proline, glutamate and leucine rich protein 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
PLAC1 placenta-specific 1
POLL polymerase (DNA directed), lambda
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
POMT2 protein-O-mannosyltransferase 2
PPP6R3 protein phosphatase 6, regulatory subunit 3
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PQLC2 PQ loop repeat containing 2
PTOV1 prostate tumor overexpressed 1
RBM15B RNA binding motif protein 15B
RHBDD3 rhomboid domain containing 3
RPL13P5 ribosomal protein L13 pseudogene 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SAYSD1 SAYSVFN motif domain containing 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SF3A2 splicing factor 3a, subunit 2, 66kDa
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SRD5A3 steroid 5 alpha-reductase 3
STIM1 stromal interaction molecule 1
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TRAPPC13 trafficking protein particle complex 13
UNC93B1 unc-93 homolog B1 (C. elegans)
USB1 U6 snRNA biogenesis 1
VAV1 vav 1 guanine nucleotide exchange factor
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR76 WD repeat domain 76
WDR91 WD repeat domain 91
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZFP30 ZFP30 zinc finger protein
ZNF134 zinc finger protein 134
ZNF324 zinc finger protein 324
ZNF696 zinc finger protein 696
ZNHIT2 zinc finger, HIT-type containing 2