AG-028671-6582 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the AG-028671-6582 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY6 adenylate cyclase 6
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
APH1A APH1A gamma secretase subunit
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
ARFIP1 ADP-ribosylation factor interacting protein 1
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARPP19 cAMP-regulated phosphoprotein, 19kDa
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BAX BCL2-associated X protein
BIN1 bridging integrator 1
BRWD1 bromodomain and WD repeat domain containing 1
BTBD7 BTB (POZ) domain containing 7
C14ORF79 chromosome 14 open reading frame 79
CASP1 caspase 1, apoptosis-related cysteine peptidase
CES3 carboxylesterase 3
CLN3 ceroid-lipofuscinosis, neuronal 3
CNTLN centlein, centrosomal protein
COX4I1 cytochrome c oxidase subunit IV isoform 1
CRELD1 cysteine-rich with EGF-like domains 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRNP3 cysteine-serine-rich nuclear protein 3
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
DEDD death effector domain containing
DLG5 discs, large homolog 5 (Drosophila)
DMPK dystrophia myotonica-protein kinase
EHF ets homologous factor
EN2 engrailed homeobox 2
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOC7 exocyst complex component 7
FAM127B family with sequence similarity 127, member B
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FBN1 fibrillin 1
FSCN1 fascin actin-bundling protein 1
GOLGA2 golgin A2
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H3G histone cluster 1, H3g
HPSE2 heparanase 2 (inactive)
HYAL3 hyaluronoglucosaminidase 3
ICAM1 intercellular adhesion molecule 1
IRAK4 interleukin-1 receptor-associated kinase 4
KIF13B kinesin family member 13B
KLHL36 kelch-like family member 36
KMT2A lysine (K)-specific methyltransferase 2A
LMNA lamin A/C
LMNB1 lamin B1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MDC1 mediator of DNA-damage checkpoint 1
MECR mitochondrial trans-2-enoyl-CoA reductase
MED25 mediator complex subunit 25
MRC2 mannose receptor, C type 2
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDE1 nudE neurodevelopment protein 1
NEK3 NIMA-related kinase 3
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSBPL2 oxysterol binding protein-like 2
PARM1 prostate androgen-regulated mucin-like protein 1
PCBP2 poly(rC) binding protein 2
PEX6 peroxisomal biogenesis factor 6
POU2F2 POU class 2 homeobox 2
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP5C protein phosphatase 5, catalytic subunit
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RASA2 RAS p21 protein activator 2
RBKS ribokinase
RGCC regulator of cell cycle
RGS17 regulator of G-protein signaling 17
RNF126 ring finger protein 126
RUFY3 RUN and FYVE domain containing 3
SCARB2 scavenger receptor class B, member 2
SIRT3 sirtuin 3
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SMAD3 SMAD family member 3
SPATS2L spermatogenesis associated, serine-rich 2-like
STARD3 StAR-related lipid transfer (START) domain containing 3
TESK2 testis-specific kinase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRADD TNFRSF1A-associated via death domain
TRIM14 tripartite motif containing 14
TUBGCP3 tubulin, gamma complex associated protein 3
UBE2G2 ubiquitin-conjugating enzyme E2G 2
USF2 upstream transcription factor 2, c-fos interacting
WDR47 WD repeat domain 47
XYLT2 xylosyltransferase II
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZNF254 zinc finger protein 254
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACSL4 acyl-CoA synthetase long-chain family member 4
ADGRB2 adhesion G protein-coupled receptor B2
AIDA axin interactor, dorsalization associated
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ATG4A autophagy related 4A, cysteine peptidase
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BGLAP bone gamma-carboxyglutamate (gla) protein
C7ORF43 chromosome 7 open reading frame 43
CA5BP1 carbonic anhydrase VB pseudogene 1
CAPN1 calpain 1, (mu/I) large subunit
CBX4 chromobox homolog 4
CCDC109B coiled-coil domain containing 109B
CD70 CD70 molecule
CDK18 cyclin-dependent kinase 18
CDK9 cyclin-dependent kinase 9
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CLDND1 claudin domain containing 1
CNTN1 contactin 1
CTC1 CTS telomere maintenance complex component 1
CTGF connective tissue growth factor
DARS2 aspartyl-tRNA synthetase 2, mitochondrial
DCAF13 DDB1 and CUL4 associated factor 13
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND2D DENN/MADD domain containing 2D
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
F3 coagulation factor III (thromboplastin, tissue factor)
FAM172A family with sequence similarity 172, member A
FAT4 FAT atypical cadherin 4
FBXL2 F-box and leucine-rich repeat protein 2
FBXL6 F-box and leucine-rich repeat protein 6
FGF2 fibroblast growth factor 2 (basic)
FSD1 fibronectin type III and SPRY domain containing 1
FZD3 frizzled class receptor 3
GLT8D2 glycosyltransferase 8 domain containing 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPS2 G protein pathway suppressor 2
GREB1L growth regulation by estrogen in breast cancer-like
HOXC5 homeobox C5
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IL4R interleukin 4 receptor
JADE3 jade family PHD finger 3
KIAA0513 KIAA0513
KRT75 keratin 75, type II
LMCD1 LIM and cysteine-rich domains 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MED22 mediator complex subunit 22
MPDU1 mannose-P-dolichol utilization defect 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
PAIP2B poly(A) binding protein interacting protein 2B
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDGFD platelet derived growth factor D
PELI1 pellino E3 ubiquitin protein ligase 1
PFKP phosphofructokinase, platelet
PIAS3 protein inhibitor of activated STAT, 3
PIBF1 progesterone immunomodulatory binding factor 1
PLAU plasminogen activator, urokinase
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PROL1 proline rich, lacrimal 1
PRSS16 protease, serine, 16 (thymus)
RFX7 regulatory factor X, 7
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF38 ring finger protein 38
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAI suppressor of cancer cell invasion
SNHG20 small nucleolar RNA host gene 20
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TMEM230 transmembrane protein 230
TRIP10 thyroid hormone receptor interactor 10
TTC30A tetratricopeptide repeat domain 30A
TTN titin
TTPAL tocopherol (alpha) transfer protein-like
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBXN6 UBX domain protein 6
ULBP2 UL16 binding protein 2
USP19 ubiquitin specific peptidase 19
USP20 ubiquitin specific peptidase 20
USP6 ubiquitin specific peptidase 6
WASF1 WAS protein family, member 1
ZFHX3 zinc finger homeobox 3
ZNF165 zinc finger protein 165
ZNF250 zinc finger protein 250
ZNF446 zinc finger protein 446
ZNF552 zinc finger protein 552
ZNF606 zinc finger protein 606
ZNF639 zinc finger protein 639
ZNF665 zinc finger protein 665
ZNF74 zinc finger protein 74