AG-013608-6395 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the AG-013608-6395 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADAM29 ADAM metallopeptidase domain 29
AEBP1 AE binding protein 1
AGBL2 ATP/GTP binding protein-like 2
AMPD1 adenosine monophosphate deaminase 1
ANG angiogenin, ribonuclease, RNase A family, 5
ANPEP alanyl (membrane) aminopeptidase
APOC1 apolipoprotein C-I
AQP3 aquaporin 3 (Gill blood group)
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
BATF3 basic leucine zipper transcription factor, ATF-like 3
BDKRB1 bradykinin receptor B1
C10ORF95 chromosome 10 open reading frame 95
C6 complement component 6
CARD14 caspase recruitment domain family, member 14
CCL22 chemokine (C-C motif) ligand 22
CDC42 cell division cycle 42
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CFLAR CASP8 and FADD-like apoptosis regulator
CLCA3P chloride channel accessory 3, pseudogene
COLEC10 collectin sub-family member 10 (C-type lectin)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CT62 cancer/testis antigen 62
CTIF CBP80/20-dependent translation initiation factor
CTSF cathepsin F
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43
DES desmin
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DNAAF1 dynein, axonemal, assembly factor 1
EHD2 EH-domain containing 2
EPPIN epididymal peptidase inhibitor
ERC1 ELKS/RAB6-interacting/CAST family member 1
EXTL3 exostosin-like glycosyltransferase 3
FABP2 fatty acid binding protein 2, intestinal
FABP3 fatty acid binding protein 3, muscle and heart
GAS7 growth arrest-specific 7
GGT1 gamma-glutamyltransferase 1
GJA4 gap junction protein, alpha 4, 37kDa
GOSR2 golgi SNAP receptor complex member 2
GP2 glycoprotein 2 (zymogen granule membrane)
GP5 glycoprotein V (platelet)
GPR22 G protein-coupled receptor 22
HAPLN1 hyaluronan and proteoglycan link protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KRT37 keratin 37, type I
LARGE like-glycosyltransferase
MAOB monoamine oxidase B
MAP1A microtubule-associated protein 1A
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MGC2889 uncharacterized protein MGC2889
MIER2 mesoderm induction early response 1, family member 2
MLXIPL MLX interacting protein-like
MMP25 matrix metallopeptidase 25
MUC3B mucin 3B, cell surface associated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPAP1 nuclear pore associated protein 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH7 protocadherin 7
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTPRM protein tyrosine phosphatase, receptor type, M
RAB40C RAB40C, member RAS oncogene family
RANBP1 RAN binding protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASL10A RAS-like, family 10, member A
REM1 RAS (RAD and GEM)-like GTP-binding 1
RPL35A ribosomal protein L35a
RPS4Y1 ribosomal protein S4, Y-linked 1
SAFB scaffold attachment factor B
SH3GL3 SH3-domain GRB2-like 3
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC17A4 solute carrier family 17, member 4
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SP110 SP110 nuclear body protein
SPTA1 spectrin, alpha, erythrocytic 1
SRF serum response factor (c-fos serum response element-binding transcription factor)
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TAPBPL TAP binding protein-like
TBC1D2 TBC1 domain family, member 2
TBX1 T-box 1
TEC tec protein tyrosine kinase
TGFB2 transforming growth factor, beta 2
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TRAV8-3 T cell receptor alpha variable 8-3
UTRN utrophin
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZC3H7B zinc finger CCCH-type containing 7B

decreased expression

Symbol Name
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
APOL6 apolipoprotein L, 6
ASGR2 asialoglycoprotein receptor 2
C5AR2 complement component 5a receptor 2
C8ORF17 chromosome 8 open reading frame 17
CALML5 calmodulin-like 5
CAMK1 calcium/calmodulin-dependent protein kinase I
CCNJL cyclin J-like
CD79A CD79a molecule, immunoglobulin-associated alpha
CD82 CD82 molecule
CFHR4 complement factor H-related 4
CLDN10 claudin 10
COL6A3 collagen, type VI, alpha 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CXCR1 chemokine (C-X-C motif) receptor 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DPF1 D4, zinc and double PHD fingers family 1
DYM dymeclin
EGF epidermal growth factor
EN2 engrailed homeobox 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM66D family with sequence similarity 66, member D
FAT4 FAT atypical cadherin 4
FRK fyn-related Src family tyrosine kinase
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GJA9 gap junction protein, alpha 9, 59kDa
GLDC glycine dehydrogenase (decarboxylating)
GMPR guanosine monophosphate reductase
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR157 G protein-coupled receptor 157
GRAP GRB2-related adaptor protein
GRPR gastrin-releasing peptide receptor
HIST1H4E histone cluster 1, H4e
HPN hepsin
IGLL1 immunoglobulin lambda-like polypeptide 1
IL11RA interleukin 11 receptor, alpha
JMJD4 jumonji domain containing 4
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4
KCNK5 potassium channel, two pore domain subfamily K, member 5
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF13 Kruppel-like factor 13
KLHL25 kelch-like family member 25
LHX6 LIM homeobox 6
LIN7B lin-7 homolog B (C. elegans)
LPPR1 lipid phosphate phosphatase-related protein type 1
LY86 lymphocyte antigen 86
MAL mal, T-cell differentiation protein
MAP2 microtubule-associated protein 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MYO15A myosin XVA
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NIPAL2 NIPA-like domain containing 2
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NME5 NME/NM23 family member 5
NPFFR1 neuropeptide FF receptor 1
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
PARP3 poly (ADP-ribose) polymerase family, member 3
PCDH11X protocadherin 11 X-linked
PCDHGA10 protocadherin gamma subfamily A, 10
PGR progesterone receptor
PICK1 protein interacting with PRKCA 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PQLC3 PQ loop repeat containing 3
PRAMEF10 PRAME family member 10
PRB3 proline-rich protein BstNI subfamily 3
PSCA prostate stem cell antigen
PWAR5 Prader Willi/Angelman region RNA 5
PXDC1 PX domain containing 1
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RIN1 Ras and Rab interactor 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF185 ring finger protein 185
RUSC2 RUN and SH3 domain containing 2
SAYSD1 SAYSVFN motif domain containing 1
SH3D21 SH3 domain containing 21
SIPA1 signal-induced proliferation-associated 1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNTG1 syntrophin, gamma 1
SPRR1B small proline-rich protein 1B
SPTBN4 spectrin, beta, non-erythrocytic 4
SPTBN5 spectrin, beta, non-erythrocytic 5
TAS2R8 taste receptor, type 2, member 8
TBX3 T-box 3
TMEM144 transmembrane protein 144
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMLHE trimethyllysine hydroxylase, epsilon
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
UPK3A uroplakin 3A
WDR78 WD repeat domain 78
ZG16 zymogen granule protein 16
ZNF674 zinc finger protein 674
ZNF747 zinc finger protein 747
ZNF816 zinc finger protein 816