AG-012559-6889 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the AG-012559-6889 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
AKAP10 A kinase (PRKA) anchor protein 10
ALS2CL ALS2 C-terminal like
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APC2 adenomatosis polyposis coli 2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATP9A ATPase, class II, type 9A
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BICD1 bicaudal D homolog 1 (Drosophila)
BMP2K BMP2 inducible kinase
C14ORF93 chromosome 14 open reading frame 93
C21ORF2 chromosome 21 open reading frame 2
C7ORF43 chromosome 7 open reading frame 43
CACFD1 calcium channel flower domain containing 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CADM1 cell adhesion molecule 1
CBX8 chromobox homolog 8
CCDC176 coiled-coil domain containing 176
CCNJL cyclin J-like
CD82 CD82 molecule
CD8A CD8a molecule
CGREF1 cell growth regulator with EF-hand domain 1
CNOT8 CCR4-NOT transcription complex, subunit 8
COBLL1 cordon-bleu WH2 repeat protein-like 1
CYBB cytochrome b-245, beta polypeptide
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOC2A double C2-like domains, alpha
ESR1 estrogen receptor 1
EVI5 ecotropic viral integration site 5
FAM105A family with sequence similarity 105, member A
FAM188A family with sequence similarity 188, member A
FGF4 fibroblast growth factor 4
FILIP1L filamin A interacting protein 1-like
GPATCH4 G patch domain containing 4
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HCFC2 host cell factor C2
HFE hemochromatosis
HIST1H1B histone cluster 1, H1b
HIST1H2AJ histone cluster 1, H2aj
HIST1H3B histone cluster 1, H3b
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNMT histamine N-methyltransferase
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IFI27 interferon, alpha-inducible protein 27
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KIF13A kinesin family member 13A
L1CAM L1 cell adhesion molecule
LARP6 La ribonucleoprotein domain family, member 6
LECT2 leukocyte cell-derived chemotaxin 2
LMF1 lipase maturation factor 1
LRP12 low density lipoprotein receptor-related protein 12
LRRC41 leucine rich repeat containing 41
MARS methionyl-tRNA synthetase
MATK megakaryocyte-associated tyrosine kinase
MET MET proto-oncogene, receptor tyrosine kinase
METTL7A methyltransferase like 7A
MPPE1 metallophosphoesterase 1
NAAA N-acylethanolamine acid amidase
NADK NAD kinase
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
OTUD4 OTU deubiquitinase 4
PALM paralemmin
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4A phosphodiesterase 4A, cAMP-specific
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PHKA2 phosphorylase kinase, alpha 2 (liver)
POLL polymerase (DNA directed), lambda
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPT2 palmitoyl-protein thioesterase 2
PTBP3 polypyrimidine tract binding protein 3
RAD51B RAD51 paralog B
RPL10L ribosomal protein L10-like
RUFY3 RUN and FYVE domain containing 3
SH3BP2 SH3-domain binding protein 2
SIRT3 sirtuin 3
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNX13 sorting nexin 13
STOML1 stomatin (EPB72)-like 1
STRA6 stimulated by retinoic acid 6
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TADA2A transcriptional adaptor 2A
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCTN2 tectonic family member 2
TMPRSS2 transmembrane protease, serine 2
TRIM29 tripartite motif containing 29
TWF2 twinfilin actin binding protein 2
WIZ widely interspaced zinc finger motifs
ZFPL1 zinc finger protein-like 1
ZNF202 zinc finger protein 202
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACSF2 acyl-CoA synthetase family member 2
ALOX15 arachidonate 15-lipoxygenase
ANXA1 annexin A1
ARC activity-regulated cytoskeleton-associated protein
ARID3B AT rich interactive domain 3B (BRIGHT-like)
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BBS7 Bardet-Biedl syndrome 7
BGLAP bone gamma-carboxyglutamate (gla) protein
C17ORF80 chromosome 17 open reading frame 80
C19ORF73 chromosome 19 open reading frame 73
C5 complement component 5
CCDC7 coiled-coil domain containing 7
CFD complement factor D (adipsin)
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLEC4E C-type lectin domain family 4, member E
CSF1R colony stimulating factor 1 receptor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DENND4A DENN/MADD domain containing 4A
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIXDC1 DIX domain containing 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DTX2 deltex 2, E3 ubiquitin ligase
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERCC2 excision repair cross-complementation group 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM131A family with sequence similarity 131, member A
FAM169A family with sequence similarity 169, member A
FKBP10 FK506 binding protein 10, 65 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSL1 FOS-like antigen 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRB7 growth factor receptor-bound protein 7
HOXA4 homeobox A4
HPS5 Hermansky-Pudlak syndrome 5
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
INF2 inverted formin, FH2 and WH2 domain containing
INPP5J inositol polyphosphate-5-phosphatase J
IRAK4 interleukin-1 receptor-associated kinase 4
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
LHX6 LIM homeobox 6
LIME1 Lck interacting transmembrane adaptor 1
LRRC20 leucine rich repeat containing 20
LY6D lymphocyte antigen 6 complex, locus D
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCC mutated in colorectal cancers
NDE1 nudE neurodevelopment protein 1
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OLFML2A olfactomedin-like 2A
OSMR oncostatin M receptor
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PACS1 phosphofurin acidic cluster sorting protein 1
PGBD5 piggyBac transposable element derived 5
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G10 phospholipase A2, group X
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PODXL2 podocalyxin-like 2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
QSER1 glutamine and serine rich 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
RNF39 ring finger protein 39
RPAP1 RNA polymerase II associated protein 1
SCGB2A2 secretoglobin, family 2A, member 2
SIRT6 sirtuin 6
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SPRY2 sprouty homolog 2 (Drosophila)
STAG3 stromal antigen 3
STK25 serine/threonine kinase 25
SULT4A1 sulfotransferase family 4A, member 1
SYCP2 synaptonemal complex protein 2
TBKBP1 TBK1 binding protein 1
TMEM115 transmembrane protein 115
TMEM2 transmembrane protein 2
TMEM254 transmembrane protein 254
TNS2 tensin 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF304 zinc finger protein 304
ZNF324 zinc finger protein 324
ZNF551 zinc finger protein 551
ZNF557 zinc finger protein 557
ZNF571 zinc finger protein 571
ZNF675 zinc finger protein 675