8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity Gene Set

Dataset GO Molecular Function Annotations
Category structural or functional annotations
Type molecular function
Description Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. (Gene Ontology, GO_0035539)
External Link http://amigo.geneontology.org/amigo/term/GO:0035539
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Genes

2 genes performing the 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

Symbol Name
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15