697 Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description Human B cell precursor leukemia; established from the bone marrow of a 12-year-old boy with acute lymphoblastic leukemia (cALL) at relapse in 1979. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001969)
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Genes

575 gene knockdowns changing fitness of 697 relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.69958
HDAC10 histone deacetylase 10 2.65992
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 2.32506
TONSL tonsoku-like, DNA repair protein 2.29494
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.25999
TMOD1 tropomodulin 1 2.25345
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.24151
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.15482
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 2.07395
TUSC3 tumor suppressor candidate 3 2.05474
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.05172
GPR27 G protein-coupled receptor 27 2.02486
ELAVL1 ELAV like RNA binding protein 1 2.00848
ATR ATR serine/threonine kinase 1.96002
IRX5 iroquois homeobox 5 1.94549
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 1.9192
HIST1H2AG histone cluster 1, H2ag 1.90227
SCN5A sodium channel, voltage gated, type V alpha subunit 1.89856
SFN stratifin 1.89475
SPRYD7 SPRY domain containing 7 1.87419
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 1.83794
HMGN1 high mobility group nucleosome binding domain 1 1.82428
PI4KAP2 phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2 1.81211
PPT2 palmitoyl-protein thioesterase 2 1.81172
GRAP GRB2-related adaptor protein 1.80968
SAMD4B sterile alpha motif domain containing 4B 1.80714
PNPLA8 patatin-like phospholipase domain containing 8 1.79266
MAP3K12 mitogen-activated protein kinase kinase kinase 12 1.78069
TUBD1 tubulin, delta 1 1.76833
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 1.75854
RABL3 RAB, member of RAS oncogene family-like 3 1.75356
FETUB fetuin B 1.74617
ANXA8L1 annexin A8-like 1 1.73803
P3H2 prolyl 3-hydroxylase 2 1.70838
IL7R interleukin 7 receptor 1.70731
ZFYVE9 zinc finger, FYVE domain containing 9 1.70053
AGPAT6 1-acylglycerol-3-phosphate O-acyltransferase 6 1.68805
SLC39A4 solute carrier family 39 (zinc transporter), member 4 1.67817
UNC5C unc-5 homolog C (C. elegans) 1.6558
SNRPB2 small nuclear ribonucleoprotein polypeptide B 1.64898
PTPRC protein tyrosine phosphatase, receptor type, C 1.64729
HIST1H2AL histone cluster 1, H2al 1.63806
IL17C interleukin 17C 1.63604
KCTD6 potassium channel tetramerization domain containing 6 1.63132
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 1.62141
GNS glucosamine (N-acetyl)-6-sulfatase 1.61391
SUOX sulfite oxidase 1.60866
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 1.60717
AGBL2 ATP/GTP binding protein-like 2 1.6002
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 1.59589
PLK3 polo-like kinase 3 1.58762
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 1.57401
ARSE arylsulfatase E (chondrodysplasia punctata 1) 1.5734
OSR2 odd-skipped related transciption factor 2 1.56886
ANKRD29 ankyrin repeat domain 29 1.56261
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 1.56087
AHCTF1 AT hook containing transcription factor 1 1.55979
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 1.55739
ZNF696 zinc finger protein 696 1.55697
OTX2 orthodenticle homeobox 2 1.55292
GTPBP1 GTP binding protein 1 1.55257
MORC3 MORC family CW-type zinc finger 3 1.55209
ZNF41 zinc finger protein 41 1.55205
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 1.54485
RAB34 RAB34, member RAS oncogene family 1.54102
DHFR dihydrofolate reductase 1.53755
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 1.53646
GATAD2A GATA zinc finger domain containing 2A 1.52972
LAMA2 laminin, alpha 2 1.52311
HCK HCK proto-oncogene, Src family tyrosine kinase 1.50563
TARBP1 TAR (HIV-1) RNA binding protein 1 1.50325
SSTR1 somatostatin receptor 1 1.50066
ZFHX3 zinc finger homeobox 3 1.49724
CHD6 chromodomain helicase DNA binding protein 6 1.49497
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 1.49491
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 1.49157
KDM1A lysine (K)-specific demethylase 1A 1.48412
FTH1P3 ferritin, heavy polypeptide 1 pseudogene 3 1.47448
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 1.47385
LOC286297 uncharacterized LOC286297 1.46748
SCUBE3 signal peptide, CUB domain, EGF-like 3 1.45368
CFLAR CASP8 and FADD-like apoptosis regulator 1.45045
CDH5 cadherin 5, type 2 (vascular endothelium) 1.44601
PCBP1 poly(rC) binding protein 1 1.44094
CREG1 cellular repressor of E1A-stimulated genes 1 1.43218
TRIM54 tripartite motif containing 54 1.42655
CASR calcium-sensing receptor 1.42113
RC3H2 ring finger and CCCH-type domains 2 1.41971
OXSM 3-oxoacyl-ACP synthase, mitochondrial 1.40989
CHRM4 cholinergic receptor, muscarinic 4 1.40805
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.40377
RSPO3 R-spondin 3 1.40035
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 1.37315
MIS18BP1 MIS18 binding protein 1 1.37246
APLP1 amyloid beta (A4) precursor-like protein 1 1.36833
TRIP4 thyroid hormone receptor interactor 4 1.36143
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 1.35678
OR7C2 olfactory receptor, family 7, subfamily C, member 2 1.35321
LIG4 ligase IV, DNA, ATP-dependent 1.35295
THBS3 thrombospondin 3 1.34909
ZNF655 zinc finger protein 655 1.34702
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1 1.32577
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 1.32491
NUP98 nucleoporin 98kDa 1.32187
HIST1H2AH histone cluster 1, H2ah 1.31804
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 1.31764
PTP4A2 protein tyrosine phosphatase type IVA, member 2 1.31436
FANCD2 Fanconi anemia, complementation group D2 1.31398
TRAFD1 TRAF-type zinc finger domain containing 1 1.31246
PTAFR platelet-activating factor receptor 1.30789
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 1.3055
TMEM126B transmembrane protein 126B 1.29495
INPP5K inositol polyphosphate-5-phosphatase K 1.29058
DHRS4L2 dehydrogenase/reductase (SDR family) member 4 like 2 1.28756
AAK1 AP2 associated kinase 1 1.2846
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 1.27754
JAK3 Janus kinase 3 1.27459
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 1.26843
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 1.26781
UBXN6 UBX domain protein 6 1.26056
ZNF12 zinc finger protein 12 1.26022
TRPC7 transient receptor potential cation channel, subfamily C, member 7 1.2597
NEB nebulin 1.2458
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 1.24106
HIST2H2AC histone cluster 2, H2ac 1.24104
PLD2 phospholipase D2 1.23999
SHBG sex hormone-binding globulin 1.23711
ALX3 ALX homeobox 3 1.23654
FAT4 FAT atypical cadherin 4 1.23069
SMAD5 SMAD family member 5 1.22961
ECEL1 endothelin converting enzyme-like 1 1.22883
TRPM6 transient receptor potential cation channel, subfamily M, member 6 1.22861
SNAPIN SNAP-associated protein 1.22834
HIST1H2AD histone cluster 1, H2ad 1.22361
DHRS4L1 dehydrogenase/reductase (SDR family) member 4 like 1 1.21574
SOX6 SRY (sex determining region Y)-box 6 1.21537
PLEKHA5 pleckstrin homology domain containing, family A member 5 1.2137
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 1.21025
MAP3K13 mitogen-activated protein kinase kinase kinase 13 1.20193
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 1.19957
TPTE transmembrane phosphatase with tensin homology 1.19873
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 1.19799
IRX6 iroquois homeobox 6 1.19758
RPN1 ribophorin I 1.19276
MC5R melanocortin 5 receptor 1.19179
RARA retinoic acid receptor, alpha 1.18863
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 1.18658
ZNF747 zinc finger protein 747 1.18526
STK38L serine/threonine kinase 38 like 1.18172
CDCA8 cell division cycle associated 8 1.18106
MAGED1 melanoma antigen family D1 1.17852
DDB2 damage-specific DNA binding protein 2, 48kDa 1.17701
PHPT1 phosphohistidine phosphatase 1 1.17309
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.17271
SLC26A3 solute carrier family 26 (anion exchanger), member 3 1.17185
BOK BCL2-related ovarian killer 1.17067
NFYB nuclear transcription factor Y, beta 1.17059
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 1.16834
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 1.16759
RECQL4 RecQ protein-like 4 1.16755
HOXD13 homeobox D13 1.1672
NID1 nidogen 1 1.1663
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 1.16615
TESK2 testis-specific kinase 2 1.1639
ALPPL2 alkaline phosphatase, placental-like 2 1.16265
SNRPA small nuclear ribonucleoprotein polypeptide A 1.15927
ATOH7 atonal homolog 7 (Drosophila) 1.15594
IRAK4 interleukin-1 receptor-associated kinase 4 1.15364
SAE1 SUMO1 activating enzyme subunit 1 1.14978
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 1.14918
PITRM1 pitrilysin metallopeptidase 1 1.14825
HSD3BP4 hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 4 1.14807
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 1.14759
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.14694
ZFP62 ZFP62 zinc finger protein 1.14562
ADRA1B adrenoceptor alpha 1B 1.14365
NOXA1 NADPH oxidase activator 1 1.14324
L3MBTL4 l(3)mbt-like 4 (Drosophila) 1.1432
PCSK9 proprotein convertase subtilisin/kexin type 9 1.14319
TUBA1A tubulin, alpha 1a 1.143
SLC35B1 solute carrier family 35, member B1 1.14127
ZNF791 zinc finger protein 791 1.14028
KRAS Kirsten rat sarcoma viral oncogene homolog 1.13947
KIF1C kinesin family member 1C 1.1382
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 1.13708
WNT7B wingless-type MMTV integration site family, member 7B 1.13208
HOXC11 homeobox C11 1.13186
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.12776
DHRS4 dehydrogenase/reductase (SDR family) member 4 1.12699
OVCA2 ovarian tumor suppressor candidate 2 1.12469
NCOA4 nuclear receptor coactivator 4 1.12417
PBX2 pre-B-cell leukemia homeobox 2 1.12323
GMIP GEM interacting protein 1.1214
SMAD9 SMAD family member 9 1.12126
ARHGAP17 Rho GTPase activating protein 17 1.1192
SRPK1 SRSF protein kinase 1 1.11386
MBD3 methyl-CpG binding domain protein 3 1.11373
HIST1H3H histone cluster 1, H3h 1.11188
FBN2 fibrillin 2 1.11072
ADRBK1 adrenergic, beta, receptor kinase 1 1.11066
HIST1H2AE histone cluster 1, H2ae 1.11053
REPIN1 replication initiator 1 1.10489
UBA2 ubiquitin-like modifier activating enzyme 2 1.1029
UBQLN4 ubiquilin 4 1.10089
ZBTB16 zinc finger and BTB domain containing 16 1.1001
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 1.09905
GYLTL1B glycosyltransferase-like 1B 1.09877
UBE2F ubiquitin-conjugating enzyme E2F (putative) 1.09762
KATNB1 katanin p80 (WD repeat containing) subunit B 1 1.09596
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 1.09583
C14ORF39 chromosome 14 open reading frame 39 1.0952
BAG2 BCL2-associated athanogene 2 1.0923
RUFY1 RUN and FYVE domain containing 1 1.08621
SF3B3 splicing factor 3b, subunit 3, 130kDa 1.08432
RBP5 retinol binding protein 5, cellular 1.07972
UFC1 ubiquitin-fold modifier conjugating enzyme 1 1.07961
ZNF160 zinc finger protein 160 1.07792
TOP2A topoisomerase (DNA) II alpha 170kDa 1.07707
MAP3K4 mitogen-activated protein kinase kinase kinase 4 1.07694
EPX eosinophil peroxidase 1.0731
RPL22 ribosomal protein L22 1.073
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 1.07225
PPP1R16A protein phosphatase 1, regulatory subunit 16A 1.06316
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 1.06081
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 1.06054
HIST1H2AI histone cluster 1, H2ai 1.05843
CSF1 colony stimulating factor 1 (macrophage) 1.05588
PPP6C protein phosphatase 6, catalytic subunit 1.05538
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 1.05287
TRIM31 tripartite motif containing 31 1.05218
TNPO2 transportin 2 1.05139
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 1.05065
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 1.04879
NPHP4 nephronophthisis 4 1.04878
SLC35E1 solute carrier family 35, member E1 1.0487
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 1.04859
ZNF282 zinc finger protein 282 1.04624
EZR ezrin 1.04622
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 1.04597
H2AFX H2A histone family, member X 1.04553
SP4 Sp4 transcription factor 1.04273
G6PC2 glucose-6-phosphatase, catalytic, 2 1.0425
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 1.04236
OAZ1 ornithine decarboxylase antizyme 1 1.04055
DPP4 dipeptidyl-peptidase 4 1.03929
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 1.03512
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene 1.03459
SOX14 SRY (sex determining region Y)-box 14 1.03408
FAM120A family with sequence similarity 120A 1.03262
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 1.03097
ONECUT2 one cut homeobox 2 1.02686
LRP11 low density lipoprotein receptor-related protein 11 1.02568
RAD23A RAD23 homolog A (S. cerevisiae) 1.02526
CXCR2 chemokine (C-X-C motif) receptor 2 1.02321
EN2 engrailed homeobox 2 1.01745
PARP12 poly (ADP-ribose) polymerase family, member 12 1.01499
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 1.01455
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 1.01446
RAB22A RAB22A, member RAS oncogene family 1.01393
CLASP2 cytoplasmic linker associated protein 2 1.0113
DEFB1 defensin, beta 1 1.0098
NUP155 nucleoporin 155kDa 1.00943
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 1.00936
PTBP1 polypyrimidine tract binding protein 1 1.00863
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 1.00824
TICAM2 toll-like receptor adaptor molecule 2 1.00538
HPR haptoglobin-related protein 1.00355
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 1.0031
STAMBPL1 STAM binding protein-like 1 1.00179
CASC1 cancer susceptibility candidate 1 1.00117

decreased fitness

Symbol Name Standardized Value
SEC23B Sec23 homolog B (S. cerevisiae) -3.55317
ZNF234 zinc finger protein 234 -3.21292
TRIM27 tripartite motif containing 27 -2.82565
STX6 syntaxin 6 -2.80457
SACS sacsin molecular chaperone -2.78898
ADGRG6 adhesion G protein-coupled receptor G6 -2.74982
CLTA clathrin, light chain A -2.70549
RAB3A RAB3A, member RAS oncogene family -2.66584
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1 -2.58022
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.57571
ZWILCH zwilch kinetochore protein -2.47503
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.37607
CD58 CD58 molecule -2.30676
IMPACT impact RWD domain protein -2.2474
DNM1P46 dynamin 1 pseudogene 46 -2.15615
MAN2A1 mannosidase, alpha, class 2A, member 1 -2.15213
TCERG1L transcription elongation regulator 1-like -2.14097
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -2.11559
RAB15 RAB15, member RAS oncogene family -2.10626
KRT6A keratin 6A, type II -2.088
LTBP4 latent transforming growth factor beta binding protein 4 -2.06146
RGS1 regulator of G-protein signaling 1 -2.04927
TMED7 transmembrane emp24 protein transport domain containing 7 -2.03867
MAPRE2 microtubule-associated protein, RP/EB family, member 2 -2.03843
ADGRE5 adhesion G protein-coupled receptor E5 -2.02188
SORCS2 sortilin-related VPS10 domain containing receptor 2 -2.00585
ATXN7 ataxin 7 -1.99431
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -1.97935
ACOT12 acyl-CoA thioesterase 12 -1.95908
ITGA9 integrin, alpha 9 -1.93371
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 -1.92284
CRNN cornulin -1.92215
CD72 CD72 molecule -1.91826
ZNF645 zinc finger protein 645 -1.91608
NHLH2 nescient helix loop helix 2 -1.91333
CD302 CD302 molecule -1.90638
ATP10A ATPase, class V, type 10A -1.90575
SMAD2 SMAD family member 2 -1.9008
IKZF2 IKAROS family zinc finger 2 (Helios) -1.89967
LYRM7 LYR motif containing 7 -1.88579
EDN1 endothelin 1 -1.88387
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -1.87919
PCSK4 proprotein convertase subtilisin/kexin type 4 -1.87093
UHMK1 U2AF homology motif (UHM) kinase 1 -1.87062
IL21 interleukin 21 -1.86106
IGFBP6 insulin-like growth factor binding protein 6 -1.85393
PSAP prosaposin -1.84502
EBF1 early B-cell factor 1 -1.83924
PSKH2 protein serine kinase H2 -1.83632
PDK2 pyruvate dehydrogenase kinase, isozyme 2 -1.83443
MBNL1 muscleblind-like splicing regulator 1 -1.82173
OPN1LW opsin 1 (cone pigments), long-wave-sensitive -1.82131
PPAP2A phosphatidic acid phosphatase type 2A -1.82076
CPNE3 copine III -1.80196
PRDX6 peroxiredoxin 6 -1.80187
SLC6A16 solute carrier family 6, member 16 -1.79935
DGCR2 DiGeorge syndrome critical region gene 2 -1.79344
CETP cholesteryl ester transfer protein, plasma -1.7932
DRG2 developmentally regulated GTP binding protein 2 -1.78893
LGI1 leucine-rich, glioma inactivated 1 -1.78709
RWDD2A RWD domain containing 2A -1.76764
TRAIP TRAF interacting protein -1.75875
PGRMC2 progesterone receptor membrane component 2 -1.75497
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -1.75065
STARD8 StAR-related lipid transfer (START) domain containing 8 -1.74779
CPA6 carboxypeptidase A6 -1.74415
NCLN nicalin -1.7297
HNRNPR heterogeneous nuclear ribonucleoprotein R -1.72397
DRD2 dopamine receptor D2 -1.71877
PDCL phosducin-like -1.69947
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -1.68509
ZNF433 zinc finger protein 433 -1.67924
LY75-CD302 LY75-CD302 readthrough -1.67479
LCK LCK proto-oncogene, Src family tyrosine kinase -1.66822
KCTD3 potassium channel tetramerization domain containing 3 -1.66805
MICU1 mitochondrial calcium uptake 1 -1.66714
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -1.66369
CCND3 cyclin D3 -1.66148
CASP8 caspase 8, apoptosis-related cysteine peptidase -1.66014
AKAP3 A kinase (PRKA) anchor protein 3 -1.64713
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -1.64624
PDIK1L PDLIM1 interacting kinase 1 like -1.64602
HRG histidine-rich glycoprotein -1.63712
CDC14C cell division cycle 14C -1.62663
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -1.62156
SLC39A1 solute carrier family 39 (zinc transporter), member 1 -1.61599
RAB6B RAB6B, member RAS oncogene family -1.60921
DCN decorin -1.60732
ESX1 ESX homeobox 1 -1.60543
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -1.60184
DFNA5 deafness, autosomal dominant 5 -1.57269
KRT28 keratin 28, type I -1.57152
PHF6 PHD finger protein 6 -1.56617
DICER1 dicer 1, ribonuclease type III -1.56449
ADAM9 ADAM metallopeptidase domain 9 -1.56212
PLK2 polo-like kinase 2 -1.53216
EPHB1 EPH receptor B1 -1.5237
MOCS2 molybdenum cofactor synthesis 2 -1.52289
SYT10 synaptotagmin X -1.51992
PCDHGA5 protocadherin gamma subfamily A, 5 -1.51882
SFXN1 sideroflexin 1 -1.51782
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene) -1.50963
ANXA1 annexin A1 -1.50701
RHCE Rh blood group, CcEe antigens -1.50433
WNT9B wingless-type MMTV integration site family, member 9B -1.49753
MDK midkine (neurite growth-promoting factor 2) -1.49498
ITGA6 integrin, alpha 6 -1.48954
WFDC10B WAP four-disulfide core domain 10B -1.48798
RHO rhodopsin -1.48656
TACC3 transforming, acidic coiled-coil containing protein 3 -1.48404
DSG1 desmoglein 1 -1.48201
PTGFR prostaglandin F receptor (FP) -1.47158
TCEA3 transcription elongation factor A (SII), 3 -1.46981
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) -1.45242
ZNF25 zinc finger protein 25 -1.4506
NAV3 neuron navigator 3 -1.44357
KPNA3 karyopherin alpha 3 (importin alpha 4) -1.44293
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 -1.44227
INPP5F inositol polyphosphate-5-phosphatase F -1.44193
UBE3A ubiquitin protein ligase E3A -1.43848
C10ORF10 chromosome 10 open reading frame 10 -1.43838
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -1.43815
CAMKV CaM kinase-like vesicle-associated -1.43744
DCP1A decapping mRNA 1A -1.43738
TARDBP TAR DNA binding protein -1.43645
C6ORF118 chromosome 6 open reading frame 118 -1.43288
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -1.43209
ZNF513 zinc finger protein 513 -1.43111
PADI3 peptidyl arginine deiminase, type III -1.42861
MSH2 mutS homolog 2 -1.4271
SPINK1 serine peptidase inhibitor, Kazal type 1 -1.42542
STX12 syntaxin 12 -1.42137
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -1.42065
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -1.41522
VHLL von Hippel-Lindau tumor suppressor-like -1.41283
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -1.41005
GPR174 G protein-coupled receptor 174 -1.4095
HDAC8 histone deacetylase 8 -1.40927
AZIN1 antizyme inhibitor 1 -1.40447
BIRC8 baculoviral IAP repeat containing 8 -1.40429
IRF4 interferon regulatory factor 4 -1.40315
TRIM60 tripartite motif containing 60 -1.40167
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 -1.39946
KRT1 keratin 1, type II -1.39846
CNTFR ciliary neurotrophic factor receptor -1.39332
BCR breakpoint cluster region -1.39258
RRAGC Ras-related GTP binding C -1.38957
KDM5D lysine (K)-specific demethylase 5D -1.38517
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -1.38179
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 -1.37817
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -1.37571
WDR90 WD repeat domain 90 -1.37303
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -1.37081
TTLL1 tubulin tyrosine ligase-like family member 1 -1.36741
CST11 cystatin 11 -1.36541
BCL7C B-cell CLL/lymphoma 7C -1.36038
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 -1.36032
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -1.35946
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -1.35941
PCSK1 proprotein convertase subtilisin/kexin type 1 -1.35601
OR10A2 olfactory receptor, family 10, subfamily A, member 2 -1.35381
CLCA2 chloride channel accessory 2 -1.35255
PTGR1 prostaglandin reductase 1 -1.35094
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) -1.34903
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 -1.34701
ACOT2 acyl-CoA thioesterase 2 -1.34106
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) -1.33639
PECAM1 platelet/endothelial cell adhesion molecule 1 -1.32648
IL2RA interleukin 2 receptor, alpha -1.31416
DEGS1 delta(4)-desaturase, sphingolipid 1 -1.3134
MPO myeloperoxidase -1.31243
FBLN1 fibulin 1 -1.31176
SOS1 son of sevenless homolog 1 (Drosophila) -1.31169
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 -1.30307
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1 -1.30278
TRIM17 tripartite motif containing 17 -1.30246
MYO18A myosin XVIIIA -1.30068
OR3A3 olfactory receptor, family 3, subfamily A, member 3 -1.30004
OR1N2 olfactory receptor, family 1, subfamily N, member 2 -1.29365
AFF1 AF4/FMR2 family, member 1 -1.28893
KRT6C keratin 6C, type II -1.28859
ADAMTSL4 ADAMTS-like 4 -1.2874
ABAT 4-aminobutyrate aminotransferase -1.28665
MEST mesoderm specific transcript -1.28301
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase -1.28096
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) -1.27941
VANGL1 VANGL planar cell polarity protein 1 -1.27899
OR2H1 olfactory receptor, family 2, subfamily H, member 1 -1.27197
HARS2 histidyl-tRNA synthetase 2, mitochondrial -1.26941
SPATS2L spermatogenesis associated, serine-rich 2-like -1.26654
MYL4 myosin, light chain 4, alkali; atrial, embryonic -1.26234
PTGR2 prostaglandin reductase 2 -1.26021
OR7G2 olfactory receptor, family 7, subfamily G, member 2 -1.25861
CTPS2 CTP synthase 2 -1.25734
TDRD9 tudor domain containing 9 -1.25428
VTA1 vesicle (multivesicular body) trafficking 1 -1.25418
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -1.25024
PARP8 poly (ADP-ribose) polymerase family, member 8 -1.24838
TATDN2 TatD DNase domain containing 2 -1.24537
AP3B1 adaptor-related protein complex 3, beta 1 subunit -1.23994
LPAR3 lysophosphatidic acid receptor 3 -1.23987
FOXD3 forkhead box D3 -1.22932
SENP5 SUMO1/sentrin specific peptidase 5 -1.22771
PPAPDC1A phosphatidic acid phosphatase type 2 domain containing 1A -1.22743
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -1.22489
CELF2 CUGBP, Elav-like family member 2 -1.22241
EXO1 exonuclease 1 -1.2189
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 -1.21737
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -1.21238
ISL1 ISL LIM homeobox 1 -1.20332
METTL14 methyltransferase like 14 -1.20066
USP49 ubiquitin specific peptidase 49 -1.1994
S100A10 S100 calcium binding protein A10 -1.1979
SGPL1 sphingosine-1-phosphate lyase 1 -1.19787
IFNA10 interferon, alpha 10 -1.1968
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 -1.19559
BTK Bruton agammaglobulinemia tyrosine kinase -1.19463
OIT3 oncoprotein induced transcript 3 -1.19394
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -1.19004
NUMA1 nuclear mitotic apparatus protein 1 -1.18646
SH3TC1 SH3 domain and tetratricopeptide repeats 1 -1.18335
CCR8 chemokine (C-C motif) receptor 8 -1.18165
SEC24D SEC24 family member D -1.18049
MAB21L2 mab-21-like 2 (C. elegans) -1.17995
GAK cyclin G associated kinase -1.1778
PCDHGA11 protocadherin gamma subfamily A, 11 -1.17384
PCDHA4 protocadherin alpha 4 -1.17139
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 -1.17137
TXNDC17 thioredoxin domain containing 17 -1.16863
UBE2J1 ubiquitin-conjugating enzyme E2, J1 -1.16747
LSAMP limbic system-associated membrane protein -1.16295
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -1.16124
FAHD1 fumarylacetoacetate hydrolase domain containing 1 -1.15992
ZMYM1 zinc finger, MYM-type 1 -1.15708
KCNK10 potassium channel, two pore domain subfamily K, member 10 -1.15555
FCRLA Fc receptor-like A -1.15086
MAST4 microtubule associated serine/threonine kinase family member 4 -1.14714
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 -1.14672
UROD uroporphyrinogen decarboxylase -1.14599
PLSCR4 phospholipid scramblase 4 -1.14338
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 -1.14327
KRT6B keratin 6B, type II -1.14104
RARB retinoic acid receptor, beta -1.14084
KRT4 keratin 4, type II -1.13955
RLF rearranged L-myc fusion -1.13666
MLKL mixed lineage kinase domain-like -1.13394
PPP1R3F protein phosphatase 1, regulatory subunit 3F -1.13039
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 -1.1292
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -1.12898
ZBTB24 zinc finger and BTB domain containing 24 -1.12368
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -1.12203
EFCAB1 EF-hand calcium binding domain 1 -1.12156
RYR2 ryanodine receptor 2 (cardiac) -1.11662
ACOX3 acyl-CoA oxidase 3, pristanoyl -1.11447
SATL1 spermidine/spermine N1-acetyl transferase-like 1 -1.11434
MAPT microtubule-associated protein tau -1.11124
IP6K3 inositol hexakisphosphate kinase 3 -1.11107
U2SURP U2 snRNP-associated SURP domain containing -1.10949
DRP2 dystrophin related protein 2 -1.10844
PRKDC protein kinase, DNA-activated, catalytic polypeptide -1.10231
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -1.10169
TPM2 tropomyosin 2 (beta) -1.0996
AIRE autoimmune regulator -1.09749
DRD4 dopamine receptor D4 -1.09709
GLP2R glucagon-like peptide 2 receptor -1.09108
GNG7 guanine nucleotide binding protein (G protein), gamma 7 -1.08928
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -1.08813
AMDHD2 amidohydrolase domain containing 2 -1.08703
ERCC8 excision repair cross-complementation group 8 -1.08203
MXD4 MAX dimerization protein 4 -1.08032
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) -1.07154
TRIP6 thyroid hormone receptor interactor 6 -1.06967
OR10A5 olfactory receptor, family 10, subfamily A, member 5 -1.06886
NSRP1 nuclear speckle splicing regulatory protein 1 -1.06872
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 -1.06732
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -1.06479
FGD4 FYVE, RhoGEF and PH domain containing 4 -1.0625
HCFC2 host cell factor C2 -1.05443
STRN4 striatin, calmodulin binding protein 4 -1.04888
BAAT bile acid CoA:amino acid N-acyltransferase -1.04625
PLSCR3 phospholipid scramblase 3 -1.0452
GPM6B glycoprotein M6B -1.04355
MXRA5 matrix-remodelling associated 5 -1.04202
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) -1.03954
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) -1.03951
JMJD1C jumonji domain containing 1C -1.03943
ADAM23 ADAM metallopeptidase domain 23 -1.03728
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -1.03525
TSHZ2 teashirt zinc finger homeobox 2 -1.03484
EDA ectodysplasin A -1.03332
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -1.03274
FAF2 Fas associated factor family member 2 -1.02972
OR10R2 olfactory receptor, family 10, subfamily R, member 2 -1.0291
NAAA N-acylethanolamine acid amidase -1.02522
LAMP1 lysosomal-associated membrane protein 1 -1.02465
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -1.0225
LEFTY1 left-right determination factor 1 -1.0165
DSG4 desmoglein 4 -1.01523
ZNF347 zinc finger protein 347 -1.01516
MYO1A myosin IA -1.01342
MDM4 MDM4, p53 regulator -1.01094
SPPL2A signal peptide peptidase like 2A -1.00739
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -1.00735
CNOT7 CCR4-NOT transcription complex, subunit 7 -1.00616
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 -1.00464