6-bromoindirubin-3'-oxime-7106 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the 6-bromoindirubin-3'-oxime-7106 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ANXA2P3 annexin A2 pseudogene 3
ARHGAP35 Rho GTPase activating protein 35
ARL3 ADP-ribosylation factor-like 3
ATAD5 ATPase family, AAA domain containing 5
ATP10A ATPase, class V, type 10A
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
C15ORF39 chromosome 15 open reading frame 39
C16ORF58 chromosome 16 open reading frame 58
C2CD2L C2CD2-like
CACTIN cactin, spliceosome C complex subunit
CALCOCO1 calcium binding and coiled-coil domain 1
CBX4 chromobox homolog 4
CCNO cyclin O
CD58 CD58 molecule
CDH7 cadherin 7, type 2
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CDKL3 cyclin-dependent kinase-like 3
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CLCN2 chloride channel, voltage-sensitive 2
CPEB1 cytoplasmic polyadenylation element binding protein 1
CSNK1E casein kinase 1, epsilon
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EFNB1 ephrin-B1
EPHA1 EPH receptor A1
EPHB2 EPH receptor B2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM214B family with sequence similarity 214, member B
FAM46C family with sequence similarity 46, member C
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF6 fibroblast growth factor 6
FLJ11292
FLT1 fms-related tyrosine kinase 1
FSCN1 fascin actin-bundling protein 1
GALT galactose-1-phosphate uridylyltransferase
GBP1 guanylate binding protein 1, interferon-inducible
HIST1H2AJ histone cluster 1, H2aj
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
INO80B INO80 complex subunit B
KDM5C lysine (K)-specific demethylase 5C
KIFC3 kinesin family member C3
KLF12 Kruppel-like factor 12
KLHL22 kelch-like family member 22
KLK13 kallikrein-related peptidase 13
KRT19P2 keratin 19 pseudogene 2
KRT6B keratin 6B, type II
LDLRAP1 low density lipoprotein receptor adaptor protein 1
MARK4 MAP/microtubule affinity-regulating kinase 4
MED14 mediator complex subunit 14
MED16 mediator complex subunit 16
MED20 mediator complex subunit 20
MFN2 mitofusin 2
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NF1 neurofibromin 1
NGDN neuroguidin, EIF4E binding protein
NID1 nidogen 1
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPIPB15 nuclear pore complex interacting protein family, member B15
NUCB1 nucleobindin 1
ONECUT2 one cut homeobox 2
PDLIM7 PDZ and LIM domain 7 (enigma)
PHC3 polyhomeotic homolog 3 (Drosophila)
PLIN2 perilipin 2
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
RAB11B RAB11B, member RAS oncogene family
RAB17 RAB17, member RAS oncogene family
RAB4B RAB4B, member RAS oncogene family
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERTAD3 SERTA domain containing 3
SFTPB surfactant protein B
SH2D2A SH2 domain containing 2A
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOGA1 suppressor of glucose, autophagy associated 1
STARD3 StAR-related lipid transfer (START) domain containing 3
STK4 serine/threonine kinase 4
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAOK1 TAO kinase 1
TAOK2 TAO kinase 2
TMEM53 transmembrane protein 53
TMPO thymopoietin
TRIM23 tripartite motif containing 23
TSPAN9 tetraspanin 9
UBOX5 U-box domain containing 5
VEGFA vascular endothelial growth factor A
ZNF512B zinc finger protein 512B
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANXA3 annexin A3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APH1A APH1A gamma secretase subunit
ARHGAP10 Rho GTPase activating protein 10
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASAP1-IT1 ASAP1 intronic transcript 1
ASNSD1 asparagine synthetase domain containing 1
ATAD2B ATPase family, AAA domain containing 2B
BAX BCL2-associated X protein
BCL6 B-cell CLL/lymphoma 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRIX1 BRX1, biogenesis of ribosomes
C11ORF30 chromosome 11 open reading frame 30
C1S complement component 1, s subcomponent
C4ORF29 chromosome 4 open reading frame 29
CLGN calmegin
COPS7B COP9 signalosome subunit 7B
CPOX coproporphyrinogen oxidase
CTGF connective tissue growth factor
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
EHD3 EH-domain containing 3
EN2 engrailed homeobox 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERF Ets2 repressor factor
ERH enhancer of rudimentary homolog (Drosophila)
ETAA1 Ewing tumor-associated antigen 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM114A2 family with sequence similarity 114, member A2
FAM169A family with sequence similarity 169, member A
FAM53B family with sequence similarity 53, member B
FOXD1 forkhead box D1
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GAB2 GRB2-associated binding protein 2
GCA grancalcin, EF-hand calcium binding protein
GID4 GID complex subunit 4
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HAUS3 HAUS augmin-like complex, subunit 3
HAUS6 HAUS augmin-like complex, subunit 6
HIRA histone cell cycle regulator
HMOX1 heme oxygenase 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
KIFC1 kinesin family member C1
KLF2 Kruppel-like factor 2
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MKNK2 MAP kinase interacting serine/threonine kinase 2
MUC3B mucin 3B, cell surface associated
NDE1 nudE neurodevelopment protein 1
NPM3 nucleophosmin/nucleoplasmin 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAIP2B poly(A) binding protein interacting protein 2B
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PEX26 peroxisomal biogenesis factor 26
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLK2 polo-like kinase 2
PTK6 protein tyrosine kinase 6
PTX3 pentraxin 3, long
RAB3A RAB3A, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RNF121 ring finger protein 121
RPGR retinitis pigmentosa GTPase regulator
RPIA ribose 5-phosphate isomerase A
RUSC2 RUN and SH3 domain containing 2
SCAF8 SR-related CTD-associated factor 8
SH3BGR SH3 domain binding glutamate-rich protein
SHROOM2 shroom family member 2
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLC35A5 solute carrier family 35, member A5
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SMIM8 small integral membrane protein 8
SNORA21 small nucleolar RNA, H/ACA box 21
SOAT1 sterol O-acyltransferase 1
SPATA2L spermatogenesis associated 2-like
STK16 serine/threonine kinase 16
STON1 stonin 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D12 TBC1 domain family, member 12
TFB2M transcription factor B2, mitochondrial
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM121 transmembrane protein 121
TMEM183A transmembrane protein 183A
TMOD3 tropomodulin 3 (ubiquitous)
TPST2 tyrosylprotein sulfotransferase 2
TXK TXK tyrosine kinase
USP8 ubiquitin specific peptidase 8
WDR82 WD repeat domain 82
ZCCHC2 zinc finger, CCHC domain containing 2
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF180 zinc finger protein 180
ZNF217 zinc finger protein 217
ZNF222 zinc finger protein 222
ZNF358 zinc finger protein 358
ZNF552 zinc finger protein 552
ZNF675 zinc finger protein 675
ZW10 zw10 kinetochore protein