6-bromoindirubin-3'-oxime-7101 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the 6-bromoindirubin-3'-oxime-7101 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATG4B autophagy related 4B, cysteine peptidase
ATN1 atrophin 1
BAHD1 bromo adjacent homology domain containing 1
C14ORF1 chromosome 14 open reading frame 1
CALML4 calmodulin-like 4
CCPG1 cell cycle progression 1
CEP162 centrosomal protein 162kDa
CREM cAMP responsive element modulator
CRYBG3 beta-gamma crystallin domain containing 3
CSRP2 cysteine and glycine-rich protein 2
CTTN cortactin
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DLX2 distal-less homeobox 2
FAM174B family with sequence similarity 174, member B
FAM65A family with sequence similarity 65, member A
GMEB1 glucocorticoid modulatory element binding protein 1
GOSR2 golgi SNAP receptor complex member 2
HAUS6 HAUS augmin-like complex, subunit 6
HINFP histone H4 transcription factor
HIRA histone cell cycle regulator
HK2 hexokinase 2
HNMT histamine N-methyltransferase
HTATSF1 HIV-1 Tat specific factor 1
IL1R1 interleukin 1 receptor, type I
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRF6 interferon regulatory factor 6
ITGB5 integrin, beta 5
ITM2B integral membrane protein 2B
KAT2A K(lysine) acetyltransferase 2A
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAP7D3 MAP7 domain containing 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MOB1A MOB kinase activator 1A
MRPL57 mitochondrial ribosomal protein L57
MYOF myoferlin
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit
NAAA N-acylethanolamine acid amidase
NAP1L1 nucleosome assembly protein 1-like 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPH2 non-SMC condensin II complex, subunit H2
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP62CL nucleoporin 62kDa C-terminal like
OGFR opioid growth factor receptor
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAIP2B poly(A) binding protein interacting protein 2B
PCSK6 proprotein convertase subtilisin/kexin type 6
PEX26 peroxisomal biogenesis factor 26
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRODH proline dehydrogenase (oxidase) 1
PRRC2C proline-rich coiled-coil 2C
PTK6 protein tyrosine kinase 6
RECQL4 RecQ protein-like 4
RND2 Rho family GTPase 2
RPL23AP7 ribosomal protein L23a pseudogene 7
RPS28 ribosomal protein S28
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RUFY3 RUN and FYVE domain containing 3
SERBP1 SERPINE1 mRNA binding protein 1
SETD4 SET domain containing 4
SF3A2 splicing factor 3a, subunit 2, 66kDa
SF3B4 splicing factor 3b, subunit 4, 49kDa
SH2B3 SH2B adaptor protein 3
SH3BP2 SH3-domain binding protein 2
SLC25A44 solute carrier family 25, member 44
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SOAT1 sterol O-acyltransferase 1
SOD2 superoxide dismutase 2, mitochondrial
SPIDR scaffolding protein involved in DNA repair
SSPN sarcospan
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STOML1 stomatin (EPB72)-like 1
TCF12 transcription factor 12
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM127 transmembrane protein 127
TMEM161A transmembrane protein 161A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOX4 TOX high mobility group box family member 4
TPR translocated promoter region, nuclear basket protein
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAFD1 TRAF-type zinc finger domain containing 1
TRAIP TRAF interacting protein
TTC37 tetratricopeptide repeat domain 37
TTC9 tetratricopeptide repeat domain 9
U2SURP U2 snRNP-associated SURP domain containing
USP34 ubiquitin specific peptidase 34
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF473 zinc finger protein 473
ZNF518A zinc finger protein 518A
ZNHIT2 zinc finger, HIT-type containing 2

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABHD14A abhydrolase domain containing 14A
AES amino-terminal enhancer of split
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANXA1 annexin A1
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARMCX1 armadillo repeat containing, X-linked 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BIK BCL2-interacting killer (apoptosis-inducing)
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C1ORF56 chromosome 1 open reading frame 56
C5 complement component 5
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC28A coiled-coil domain containing 28A
CDK3 cyclin-dependent kinase 3
CLEC16A C-type lectin domain family 16, member A
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEAF1 DEAF1 transcription factor
DEPTOR DEP domain containing MTOR-interacting protein
DSCR3 Down syndrome critical region 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELP3 elongator acetyltransferase complex subunit 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERI3 ERI1 exoribonuclease family member 3
GAB2 GRB2-associated binding protein 2
GAS8 growth arrest-specific 8
GMIP GEM interacting protein
HIST1H2AJ histone cluster 1, H2aj
HIST1H4D histone cluster 1, H4d
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB8 heat shock 22kDa protein 8
IFI35 interferon-induced protein 35
INF2 inverted formin, FH2 and WH2 domain containing
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KDM7A lysine (K)-specific demethylase 7A
KLHDC3 kelch domain containing 3
KLHL12 kelch-like family member 12
KLHL26 kelch-like family member 26
MAMLD1 mastermind-like domain containing 1
MMP3 matrix metallopeptidase 3
NCAPD2 non-SMC condensin I complex, subunit D2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OLFML2A olfactomedin-like 2A
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCSK7 proprotein convertase subtilisin/kexin type 7
PILRB paired immunoglobin-like type 2 receptor beta
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PNRC1 proline-rich nuclear receptor coactivator 1
PSENEN presenilin enhancer gamma secretase subunit
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PVRL3 poliovirus receptor-related 3
RAB32 RAB32, member RAS oncogene family
RAB4B RAB4B, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
RGS17 regulator of G-protein signaling 17
RHOC ras homolog family member C
RIC8B RIC8 guanine nucleotide exchange factor B
RNF146 ring finger protein 146
RPL23AP32 ribosomal protein L23a pseudogene 32
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERTAD3 SERTA domain containing 3
SGPP1 sphingosine-1-phosphate phosphatase 1
SIDT1 SID1 transmembrane family, member 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMG9 SMG9 nonsense mediated mRNA decay factor
SMIM14 small integral membrane protein 14
SPAG4 sperm associated antigen 4
STX1A syntaxin 1A (brain)
SYTL2 synaptotagmin-like 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TBX19 T-box 19
TCTA T-cell leukemia translocation altered
TMEM2 transmembrane protein 2
TMEM230 transmembrane protein 230
TMPRSS3 transmembrane protease, serine 3
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTC30A tetratricopeptide repeat domain 30A
WDR76 WD repeat domain 76
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZBTB22 zinc finger and BTB domain containing 22
ZMAT3 zinc finger, matrin-type 3