6-bromoindirubin-3'-oxime-6589 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the 6-bromoindirubin-3'-oxime-6589 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADAM22 ADAM metallopeptidase domain 22
ADGRL1 adhesion G protein-coupled receptor L1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALPK1 alpha-kinase 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ATF2 activating transcription factor 2
ATP13A3 ATPase type 13A3
BAX BCL2-associated X protein
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C16ORF58 chromosome 16 open reading frame 58
C2ORF27A chromosome 2 open reading frame 27A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CES2 carboxylesterase 2
CIDEC cell death-inducing DFFA-like effector c
CNTNAP2 contactin associated protein-like 2
COMMD4 COMM domain containing 4
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CUL9 cullin 9
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DLX2 distal-less homeobox 2
DUSP9 dual specificity phosphatase 9
EIF1 eukaryotic translation initiation factor 1
ELF2 E74-like factor 2 (ets domain transcription factor)
FASLG Fas ligand (TNF superfamily, member 6)
FERMT1 fermitin family member 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GREB1L growth regulation by estrogen in breast cancer-like
HIRA histone cell cycle regulator
HIST1H4C histone cluster 1, H4c
HLA-F major histocompatibility complex, class I, F
HPX hemopexin
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IGFBP6 insulin-like growth factor binding protein 6
IL27RA interleukin 27 receptor, alpha
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KRT17 keratin 17, type I
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOC644450 uncharacterized LOC644450
LPPR2 lipid phosphate phosphatase-related protein type 2
LUZP1 leucine zipper protein 1
MGC12488
NCAPH2 non-SMC condensin II complex, subunit H2
NEK11 NIMA-related kinase 11
NPEPPS aminopeptidase puromycin sensitive
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUPL2 nucleoporin like 2
PCDH9 protocadherin 9
PCDHB13 protocadherin beta 13
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4DIP phosphodiesterase 4D interacting protein
PPAP2B phosphatidic acid phosphatase type 2B
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRAMEF11 PRAME family member 11
PRMT7 protein arginine methyltransferase 7
PSG4 pregnancy specific beta-1-glycoprotein 4
PVT1 Pvt1 oncogene (non-protein coding)
RAB35 RAB35, member RAS oncogene family
RBM5 RNA binding motif protein 5
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIN3 Ras and Rab interactor 3
RNMT RNA (guanine-7-) methyltransferase
RPL23 ribosomal protein L23
SCAF4 SR-related CTD-associated factor 4
SDC2 syndecan 2
SERBP1 SERPINE1 mRNA binding protein 1
SFXN3 sideroflexin 3
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC30A5 solute carrier family 30 (zinc transporter), member 5
ST20 suppressor of tumorigenicity 20
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STMN1 stathmin 1
SUGP1 SURP and G patch domain containing 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM121 transmembrane protein 121
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAIP TRAF interacting protein
TRMT61A tRNA methyltransferase 61A
USP2 ubiquitin specific peptidase 2
VEGFB vascular endothelial growth factor B
VIPR1 vasoactive intestinal peptide receptor 1
VIPR2 vasoactive intestinal peptide receptor 2
ZBTB7A zinc finger and BTB domain containing 7A
ZNF205 zinc finger protein 205
ZNF444 zinc finger protein 444
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADCY6 adenylate cyclase 6
AIDA axin interactor, dorsalization associated
AMIGO2 adhesion molecule with Ig-like domain 2
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ATAD5 ATPase family, AAA domain containing 5
BPGM 2,3-bisphosphoglycerate mutase
C8ORF44 chromosome 8 open reading frame 44
C9ORF40 chromosome 9 open reading frame 40
CA2 carbonic anhydrase II
CFD complement factor D (adipsin)
CHML choroideremia-like (Rab escort protein 2)
COQ6 coenzyme Q6 monooxygenase
CRYBG3 beta-gamma crystallin domain containing 3
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCTN6 dynactin 6
DGAT1 diacylglycerol O-acyltransferase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAL4 dynein, axonemal, light chain 4
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPHA2 EPH receptor A2
ERMP1 endoplasmic reticulum metallopeptidase 1
EXD3 exonuclease 3'-5' domain containing 3
FADS2 fatty acid desaturase 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GAB2 GRB2-associated binding protein 2
GOLGA8B golgin A8 family, member B
GRPR gastrin-releasing peptide receptor
GTPBP2 GTP binding protein 2
HDAC11 histone deacetylase 11
HIST1H2AI histone cluster 1, H2ai
HIST1H2BI histone cluster 1, H2bi
HOXA4 homeobox A4
IDI2-AS1 IDI2 antisense RNA 1
JAK2 Janus kinase 2
JOSD1 Josephin domain containing 1
KCTD17 potassium channel tetramerization domain containing 17
KDM7A lysine (K)-specific demethylase 7A
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MOCS3 molybdenum cofactor synthesis 3
MVD mevalonate (diphospho) decarboxylase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NME5 NME/NM23 family member 5
NPFFR1 neuropeptide FF receptor 1
NPY5R neuropeptide Y receptor Y5
NR2C2 nuclear receptor subfamily 2, group C, member 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OGFRL1 opioid growth factor receptor-like 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PARP16 poly (ADP-ribose) polymerase family, member 16
PGR progesterone receptor
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAC1 placenta-specific 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXNB3 plexin B3
POMT2 protein-O-mannosyltransferase 2
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PQLC2 PQ loop repeat containing 2
RAB5C RAB5C, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RGS19 regulator of G-protein signaling 19
RNF146 ring finger protein 146
SAYSD1 SAYSVFN motif domain containing 1
SCD5 stearoyl-CoA desaturase 5
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SGPP1 sphingosine-1-phosphate phosphatase 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
STAG3 stromal antigen 3
STK16 serine/threonine kinase 16
STK25 serine/threonine kinase 25
TMEM230 transmembrane protein 230
TMEM57 transmembrane protein 57
TNRC6B trinucleotide repeat containing 6B
UBE2W ubiquitin-conjugating enzyme E2W (putative)
ULBP2 UL16 binding protein 2
WDR76 WD repeat domain 76
ZBTB39 zinc finger and BTB domain containing 39
ZNF134 zinc finger protein 134
ZNF137P zinc finger protein 137, pseudogene
ZNF280D zinc finger protein 280D
ZNF34 zinc finger protein 34
ZNF37BP zinc finger protein 37B, pseudogene
ZNF606 zinc finger protein 606