5224221-956 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the 5224221-956 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMOTL2 angiomotin like 2
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
BCL2L11 BCL2-like 11 (apoptosis facilitator)
CBX4 chromobox homolog 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEP164 centrosomal protein 164kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLGN calmegin
CRELD1 cysteine-rich with EGF-like domains 1
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSL1 FOS-like antigen 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GLTSCR1L GLTSCR1-like
GPR87 G protein-coupled receptor 87
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HBEGF heparin-binding EGF-like growth factor
HIST1H2BJ histone cluster 1, H2bj
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMOX1 heme oxygenase 1
HSPA1L heat shock 70kDa protein 1-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
INHBE inhibin, beta E
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LARP6 La ribonucleoprotein domain family, member 6
LMO4 LIM domain only 4
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MEF2A myocyte enhancer factor 2A
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OSGIN1 oxidative stress induced growth inhibitor 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPH phosphoserine phosphatase
RAB32 RAB32, member RAS oncogene family
RGS20 regulator of G-protein signaling 20
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RNF6 ring finger protein (C3H2C3 type) 6
SAMD4A sterile alpha motif domain containing 4A
SH3BGR SH3 domain binding glutamate-rich protein
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOCS2 suppressor of cytokine signaling 2
TES testin LIM domain protein
TFE3 transcription factor binding to IGHM enhancer 3
TGFB2 transforming growth factor, beta 2
TGIF1 TGFB-induced factor homeobox 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
ULBP1 UL16 binding protein 1
VEGFA vascular endothelial growth factor A
WDR33 WD repeat domain 33
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZNF227 zinc finger protein 227
ZNF571 zinc finger protein 571

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADGRA3 adhesion G protein-coupled receptor A3
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKRD10 ankyrin repeat domain 10
ASF1B anti-silencing function 1B histone chaperone
BAHD1 bromo adjacent homology domain containing 1
BAK1 BCL2-antagonist/killer 1
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BTBD2 BTB (POZ) domain containing 2
C14ORF132 chromosome 14 open reading frame 132
C2CD2 C2 calcium-dependent domain containing 2
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCNE1 cyclin E1
CCNE2 cyclin E2
CERK ceramide kinase
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
CROT carnitine O-octanoyltransferase
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNA2 DNA replication helicase/nuclease 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFNA3 ephrin-A3
EGR3 early growth response 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERCC6L excision repair cross-complementation group 6-like
FA2H fatty acid 2-hydroxylase
FAM111A family with sequence similarity 111, member A
FAM172A family with sequence similarity 172, member A
FASTKD5 FAST kinase domains 5
FBRS fibrosin
FEN1 flap structure-specific endonuclease 1
FMO4 flavin containing monooxygenase 4
FOXC1 forkhead box C1
GEMIN6 gem (nuclear organelle) associated protein 6
GMIP GEM interacting protein
GPR19 G protein-coupled receptor 19
HIST1H2BI histone cluster 1, H2bi
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXA5 homeobox A5
HOXC13 homeobox C13
HPS6 Hermansky-Pudlak syndrome 6
HTRA1 HtrA serine peptidase 1
IFT22 intraflagellar transport 22
IP6K2 inositol hexakisphosphate kinase 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KIAA0125 KIAA0125
KIAA0894 KIAA0894 protein
KIAA0907 KIAA0907
KLHL26 kelch-like family member 26
LAMA3 laminin, alpha 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAGEF1 melanoma antigen family F1
MAMLD1 mastermind-like domain containing 1
MAPK12 mitogen-activated protein kinase 12
MAPKAP1 mitogen-activated protein kinase associated protein 1
MED24 mediator complex subunit 24
MEIS1 Meis homeobox 1
MMD monocyte to macrophage differentiation-associated
MOGS mannosyl-oligosaccharide glucosidase
MPPED2 metallophosphoesterase domain containing 2
MYLIP myosin regulatory light chain interacting protein
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5DC2 5'-nucleotidase domain containing 2
PCNA proliferating cell nuclear antigen
PEX11A peroxisomal biogenesis factor 11 alpha
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PODXL podocalyxin-like
PRKCD protein kinase C, delta
PRR15L proline rich 15-like
PTPRE protein tyrosine phosphatase, receptor type, E
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RBL1 retinoblastoma-like 1
RBM12 RNA binding motif protein 12
RECQL4 RecQ protein-like 4
RIBC2 RIB43A domain with coiled-coils 2
SALL2 spalt-like transcription factor 2
SGK1 serum/glucocorticoid regulated kinase 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SOX9 SRY (sex determining region Y)-box 9
STARD13 StAR-related lipid transfer (START) domain containing 13
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUOX sulfite oxidase
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TM7SF3 transmembrane 7 superfamily member 3
TMEM183A transmembrane protein 183A
UNC119B unc-119 homolog B (C. elegans)
WDR46 WD repeat domain 46
WRAP73 WD repeat containing, antisense to TP73
ZBED8 zinc finger, BED-type containing 8
ZMAT3 zinc finger, matrin-type 3
ZNF669 zinc finger protein 669