4-phenylbutyric acid Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation. (Chemical Entities of Biological Interest Ontology, CHEBI_41500)
External Link http://ctdbase.org/detail.go?type=chem&acc=C075773
Similar Terms
Downloads & Tools

Genes

32 genes/proteins interacting with the chemical 4-phenylbutyric acid from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
APP amyloid beta (A4) precursor protein
BAX BCL2-associated X protein
CASP12 caspase 12 (gene/pseudogene)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ERN1 endoplasmic reticulum to nucleus signaling 1
HDAC1 histone deacetylase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IL1B interleukin 1, beta
LEPR leptin receptor
MAGEA9 melanoma antigen family A9
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MECP2 methyl CpG binding protein 2
MEF2A myocyte enhancer factor 2A
NCF1 neutrophil cytosolic factor 1
NFE2L2 nuclear factor, erythroid 2-like 2
PARK7 parkinson protein 7
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
TGFB1 transforming growth factor, beta 1
TH tyrosine hydroxylase
TUBB3 tubulin, beta 3 class III
UMOD uromodulin