4-hydroxyphenazone-4175 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the 4-hydroxyphenazone-4175 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ACSM5 acyl-CoA synthetase medium-chain family member 5
ACTC1 actin, alpha, cardiac muscle 1
ADAM22 ADAM metallopeptidase domain 22
ADGRA2 adhesion G protein-coupled receptor A2
AGGF1 angiogenic factor with G patch and FHA domains 1
AHSP alpha hemoglobin stabilizing protein
AK1 adenylate kinase 1
ATP10B ATPase, class V, type 10B
BAX BCL2-associated X protein
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BDKRB1 bradykinin receptor B1
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
BTN3A1 butyrophilin, subfamily 3, member A1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF1 chromosome 14 open reading frame 1
C1ORF61 chromosome 1 open reading frame 61
CFAP69 cilia and flagella associated protein 69
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLSTN3 calsyntenin 3
CNTNAP2 contactin associated protein-like 2
COL8A1 collagen, type VIII, alpha 1
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CRHR2 corticotropin releasing hormone receptor 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
EDNRA endothelin receptor type A
EPHB1 EPH receptor B1
EPYC epiphycan
FSHB follicle stimulating hormone, beta polypeptide
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GBP1 guanylate binding protein 1, interferon-inducible
GM2A GM2 ganglioside activator
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPR1 G protein-coupled receptor 1
GPR85 G protein-coupled receptor 85
GSK3A glycogen synthase kinase 3 alpha
HAO2 hydroxyacid oxidase 2 (long chain)
HFE hemochromatosis
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IKZF2 IKAROS family zinc finger 2 (Helios)
IL2RB interleukin 2 receptor, beta
KIF21B kinesin family member 21B
KIF5C kinesin family member 5C
KLF6 Kruppel-like factor 6
KLK13 kallikrein-related peptidase 13
KMT2A lysine (K)-specific methyltransferase 2A
LAMC2 laminin, gamma 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRC48 leucine rich repeat containing 48
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MDFI MyoD family inhibitor
MED16 mediator complex subunit 16
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MID1 midline 1
NEUROG2 neurogenin 2
NIPAL3 NIPA-like domain containing 3
NOV nephroblastoma overexpressed
NR2E3 nuclear receptor subfamily 2, group E, member 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OASL 2'-5'-oligoadenylate synthetase-like
OGDHL oxoglutarate dehydrogenase-like
OMD osteomodulin
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PCDH1 protocadherin 1
PIGR polymeric immunoglobulin receptor
PKNOX2 PBX/knotted 1 homeobox 2
POFUT1 protein O-fucosyltransferase 1
POU3F2 POU class 3 homeobox 2
PPP1R10 protein phosphatase 1, regulatory subunit 10
PURG purine-rich element binding protein G
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SORBS2 sorbin and SH3 domain containing 2
SOX10 SRY (sex determining region Y)-box 10
SP100 SP100 nuclear antigen
TBCD tubulin folding cofactor D
TCP10L t-complex 10-like
TNS1 tensin 1
TRIM10 tripartite motif containing 10
TSC22D2 TSC22 domain family, member 2
TUBB7P tubulin, beta 7, pseudogene
ZFP36L1 ZFP36 ring finger protein-like 1
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADGRE1 adhesion G protein-coupled receptor E1
ADGRE5 adhesion G protein-coupled receptor E5
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ALPK1 alpha-kinase 1
ARC activity-regulated cytoskeleton-associated protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATG10 autophagy related 10
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AXIN1 axin 1
C14ORF93 chromosome 14 open reading frame 93
C17ORF53 chromosome 17 open reading frame 53
C1ORF159 chromosome 1 open reading frame 159
C1ORF54 chromosome 1 open reading frame 54
C3 complement component 3
C5AR1 complement component 5a receptor 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CD82 CD82 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CLSTN2 calsyntenin 2
CNTNAP1 contactin associated protein 1
CPB2 carboxypeptidase B2 (plasma)
CRYBB2P1 crystallin, beta B2 pseudogene 1
CUZD1 CUB and zona pellucida-like domains 1
CXADR coxsackie virus and adenovirus receptor
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DCBLD2 discoidin, CUB and LCCL domain containing 2
DLK2 delta-like 2 homolog (Drosophila)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAL4 dynein, axonemal, light chain 4
FBXL7 F-box and leucine-rich repeat protein 7
FBXO2 F-box protein 2
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF23 fibroblast growth factor 23
FOXI1 forkhead box I1
FSCN1 fascin actin-bundling protein 1
FSCN3 fascin actin-bundling protein 3, testicular
GFI1 growth factor independent 1 transcription repressor
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRB7 growth factor receptor-bound protein 7
GSTTP1 glutathione S-transferase theta pseudogene 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
INHA inhibin, alpha
IRAK4 interleukin-1 receptor-associated kinase 4
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KEL Kell blood group, metallo-endopeptidase
KLF3 Kruppel-like factor 3 (basic)
KREMEN2 kringle containing transmembrane protein 2
LHX3 LIM homeobox 3
LIN7B lin-7 homolog B (C. elegans)
LINC00597 long intergenic non-protein coding RNA 597
LOC729164 hCG1732469
LY6G6C lymphocyte antigen 6 complex, locus G6C
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAGEA3 melanoma antigen family A3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NT5DC3 5'-nucleotidase domain containing 3
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
PARG poly (ADP-ribose) glycohydrolase
PCDHGB5 protocadherin gamma subfamily B, 5
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLXNB3 plexin B3
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PRAMEF11 PRAME family member 11
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNF122 ring finger protein 122
SCN10A sodium channel, voltage gated, type X alpha subunit
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLC16A4 solute carrier family 16, member 4
SLC17A2 solute carrier family 17, member 2
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SPTA1 spectrin, alpha, erythrocytic 1
TAS2R4 taste receptor, type 2, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TH tyrosine hydroxylase
TMCC2 transmembrane and coiled-coil domain family 2
TMEM62 transmembrane protein 62
TMLHE trimethyllysine hydroxylase, epsilon
VIPR1 vasoactive intestinal peptide receptor 1
WDR25 WD repeat domain 25
WDR33 WD repeat domain 33
WDR62 WD repeat domain 62
WNT10B wingless-type MMTV integration site family, member 10B
ZBTB22 zinc finger and BTB domain containing 22
ZNF204P zinc finger protein 204, pseudogene
ZNF230 zinc finger protein 230
ZNF76 zinc finger protein 76
ZNF8 zinc finger protein 8