3-nitropropionic acid-6407 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the 3-nitropropionic acid-6407 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ANP32A-IT1 ANP32A intronic transcript 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARMC4 armadillo repeat containing 4
ATP9A ATPase, class II, type 9A
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL9 B-cell CLL/lymphoma 9
C10ORF10 chromosome 10 open reading frame 10
C8ORF60 chromosome 8 open reading frame 60
CALD1 caldesmon 1
CASZ1 castor zinc finger 1
CAV2 caveolin 2
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CISH cytokine inducible SH2-containing protein
CNOT8 CCR4-NOT transcription complex, subunit 8
COBL cordon-bleu WH2 repeat protein
COMMD4 COMM domain containing 4
CSE1L CSE1 chromosome segregation 1-like (yeast)
CUZD1 CUB and zona pellucida-like domains 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
ECE1 endothelin converting enzyme 1
EGF epidermal growth factor
EIF4E2 eukaryotic translation initiation factor 4E family member 2
ELF4 E74-like factor 4 (ets domain transcription factor)
FGFR1 fibroblast growth factor receptor 1
FUZ fuzzy planar cell polarity protein
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLS2 glutaminase 2 (liver, mitochondrial)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNS glucosamine (N-acetyl)-6-sulfatase
HMGB3P1 high mobility group box 3 pseudogene 1
HPS1 Hermansky-Pudlak syndrome 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KLHL25 kelch-like family member 25
KRIT1 KRIT1, ankyrin repeat containing
LAMC3 laminin, gamma 3
LHX2 LIM homeobox 2
LIG3 ligase III, DNA, ATP-dependent
LZTS3 leucine zipper, putative tumor suppressor family member 3
MED22 mediator complex subunit 22
MFSD6 major facilitator superfamily domain containing 6
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MR1 major histocompatibility complex, class I-related
MSL3 male-specific lethal 3 homolog (Drosophila)
MTF2 metal response element binding transcription factor 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPR2 natriuretic peptide receptor 2
NR2C1 nuclear receptor subfamily 2, group C, member 1
NRTN neurturin
PAQR6 progestin and adipoQ receptor family member VI
PFDN4 prefoldin subunit 4
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLBD1 phospholipase B domain containing 1
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PPP4R4 protein phosphatase 4, regulatory subunit 4
PTCRA pre T-cell antigen receptor alpha
PTGES prostaglandin E synthase
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAVER2 ribonucleoprotein, PTB-binding 2
RERE arginine-glutamic acid dipeptide (RE) repeats
RGS17 regulator of G-protein signaling 17
RNF122 ring finger protein 122
RPL31 ribosomal protein L31
RXRA retinoid X receptor, alpha
SIK3 SIK family kinase 3
SIVA1 SIVA1, apoptosis-inducing factor
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
STAG3 stromal antigen 3
TBXA2R thromboxane A2 receptor
TCF3 transcription factor 3
TCP11L1 t-complex 11, testis-specific-like 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TRA2A transformer 2 alpha homolog (Drosophila)
TRAIP TRAF interacting protein
TRIM3 tripartite motif containing 3
TRIP11 thyroid hormone receptor interactor 11
UHRF1BP1L UHRF1 binding protein 1-like
USP46 ubiquitin specific peptidase 46
VAC14 Vac14 homolog (S. cerevisiae)
WNT6 wingless-type MMTV integration site family, member 6
WSB1 WD repeat and SOCS box containing 1
ZHX3 zinc fingers and homeoboxes 3
ZNF277 zinc finger protein 277
ZNF286A zinc finger protein 286A
ZNF446 zinc finger protein 446
ZNF639 zinc finger protein 639
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ADGRG2 adhesion G protein-coupled receptor G2
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARRB2 arrestin, beta 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BTBD18 BTB (POZ) domain containing 18
C1QTNF1 C1q and tumor necrosis factor related protein 1
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CCDC85C coiled-coil domain containing 85C
CD80 CD80 molecule
CDH7 cadherin 7, type 2
CEP97 centrosomal protein 97kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIDEC cell death-inducing DFFA-like effector c
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CRLF1 cytokine receptor-like factor 1
DGKD diacylglycerol kinase, delta 130kDa
DMBT1 deleted in malignant brain tumors 1
DMRT1 doublesex and mab-3 related transcription factor 1
DOCK1 dedicator of cytokinesis 1
DOLPP1 dolichyldiphosphatase 1
DPF1 D4, zinc and double PHD fingers family 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM120C family with sequence similarity 120C
FAM222B family with sequence similarity 222, member B
FBXL2 F-box and leucine-rich repeat protein 2
FMO4 flavin containing monooxygenase 4
FSTL3 follistatin-like 3 (secreted glycoprotein)
GLB1L galactosidase, beta 1-like
GLDC glycine dehydrogenase (decarboxylating)
GMEB1 glucocorticoid modulatory element binding protein 1
GRIP2 glutamate receptor interacting protein 2
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HDAC4 histone deacetylase 4
HDAC9 histone deacetylase 9
HIST1H2AM histone cluster 1, H2am
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HLX H2.0-like homeobox
HMOX1 heme oxygenase 1
HOXB9 homeobox B9
HOXC13 homeobox C13
HOXC4 homeobox C4
HPS6 Hermansky-Pudlak syndrome 6
KIAA1462 KIAA1462
LAMP3 lysosomal-associated membrane protein 3
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC390998 ribosomal protein L10 pseudogene
LSP1 lymphocyte-specific protein 1
MDFI MyoD family inhibitor
MFSD11 major facilitator superfamily domain containing 11
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMP13 matrix metallopeptidase 13
MMP3 matrix metallopeptidase 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL44 mitochondrial ribosomal protein L44
MTG1 mitochondrial ribosome-associated GTPase 1
MUC3B mucin 3B, cell surface associated
NME5 NME/NM23 family member 5
NT5M 5',3'-nucleotidase, mitochondrial
NTSR1 neurotensin receptor 1 (high affinity)
OLFML2A olfactomedin-like 2A
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PARP3 poly (ADP-ribose) polymerase family, member 3
PARPBP PARP1 binding protein
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRR3 proline rich 3
PRR7 proline rich 7 (synaptic)
PTPRU protein tyrosine phosphatase, receptor type, U
RNF208 ring finger protein 208
SCN10A sodium channel, voltage gated, type X alpha subunit
SERTAD3 SERTA domain containing 3
SETBP1 SET binding protein 1
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLITRK5 SLIT and NTRK-like family, member 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK16 serine/threonine kinase 16
SYT17 synaptotagmin XVII
TAC3 tachykinin 3
TBC1D17 TBC1 domain family, member 17
THRAP3 thyroid hormone receptor associated protein 3
TMEM209 transmembrane protein 209
TSPAN12 tetraspanin 12
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBTD1 ubiquitin domain containing 1
VNN1 vanin 1
ZNF141 zinc finger protein 141
ZNF623 zinc finger protein 623
ZNF668 zinc finger protein 668