3-nitropropionic acid-6402 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the 3-nitropropionic acid-6402 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACO2 aconitase 2, mitochondrial
ACOT11 acyl-CoA thioesterase 11
ACVR1B activin A receptor, type IB
ADAM22 ADAM metallopeptidase domain 22
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADTRP androgen-dependent TFPI-regulating protein
AHSP alpha hemoglobin stabilizing protein
AIRE autoimmune regulator
AKAP5 A kinase (PRKA) anchor protein 5
AMPD1 adenosine monophosphate deaminase 1
ANGPT4 angiopoietin 4
ATP11A ATPase, class VI, type 11A
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide
ATRNL1 attractin-like 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL3 B-cell CLL/lymphoma 3
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3ORF18 chromosome 3 open reading frame 18
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CAPN2 calpain 2, (m/II) large subunit
CD48 CD48 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLIC5 chloride intracellular channel 5
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CREBBP CREB binding protein
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DNM3 dynamin 3
DOCK5 dedicator of cytokinesis 5
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DSC3 desmocollin 3
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FHL1 four and a half LIM domains 1
GNAS GNAS complex locus
GNRH2 gonadotropin-releasing hormone 2
GOSR2 golgi SNAP receptor complex member 2
GPM6A glycoprotein M6A
GPR1 G protein-coupled receptor 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICAM1 intercellular adhesion molecule 1
IFI6 interferon, alpha-inducible protein 6
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JAM3 junctional adhesion molecule 3
KCNK5 potassium channel, two pore domain subfamily K, member 5
KRT9 keratin 9, type I
LAT2 linker for activation of T cells family, member 2
LOC100131510 uncharacterized LOC100131510
LOX lysyl oxidase
LRRC1 leucine rich repeat containing 1
MALL mal, T-cell differentiation protein-like
MAPK11 mitogen-activated protein kinase 11
MMP3 matrix metallopeptidase 3
MR1 major histocompatibility complex, class I-related
NCALD neurocalcin delta
NOVA2 neuro-oncological ventral antigen 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
PCDHA10 protocadherin alpha 10
PCDHB3 protocadherin beta 3
PDE11A phosphodiesterase 11A
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLIN2 perilipin 2
PLSCR2 phospholipid scramblase 2
PML promyelocytic leukemia
PQLC3 PQ loop repeat containing 3
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PTK2B protein tyrosine kinase 2 beta
RBP4 retinol binding protein 4, plasma
RFXAP regulatory factor X-associated protein
RPL10L ribosomal protein L10-like
RPLP2 ribosomal protein, large, P2
RRH retinal pigment epithelium-derived rhodopsin homolog
SAFB scaffold attachment factor B
SAFB2 scaffold attachment factor B2
SAG S-antigen; retina and pineal gland (arrestin)
SCGB2A2 secretoglobin, family 2A, member 2
SH2D3A SH2 domain containing 3A
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SORBS1 sorbin and SH3 domain containing 1
SRPK2 SRSF protein kinase 2
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBL1Y transducin (beta)-like 1, Y-linked
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TPM2 tropomyosin 2 (beta)
TPMT thiopurine S-methyltransferase
TREX1 three prime repair exonuclease 1
TRIM3 tripartite motif containing 3
VCX2 variable charge, X-linked 2
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WNT16 wingless-type MMTV integration site family, member 16
YTHDC2 YTH domain containing 2
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADAM2 ADAM metallopeptidase domain 2
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADGRB2 adhesion G protein-coupled receptor B2
ADGRD2 adhesion G protein-coupled receptor D2
ART1 ADP-ribosyltransferase 1
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
C5ORF42 chromosome 5 open reading frame 42
CACNG3 calcium channel, voltage-dependent, gamma subunit 3
CCDC69 coiled-coil domain containing 69
CCDC71 coiled-coil domain containing 71
CD79B CD79b molecule, immunoglobulin-associated beta
CDO1 cysteine dioxygenase type 1
CFH complement factor H
CHST10 carbohydrate sulfotransferase 10
CLCA3P chloride channel accessory 3, pseudogene
CLCN6 chloride channel, voltage-sensitive 6
CLSTN3 calsyntenin 3
COL15A1 collagen, type XV, alpha 1
CPA2 carboxypeptidase A2 (pancreatic)
CSDC2 cold shock domain containing C2, RNA binding
CSF1R colony stimulating factor 1 receptor
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DMRT1 doublesex and mab-3 related transcription factor 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EPX eosinophil peroxidase
ERN1 endoplasmic reticulum to nucleus signaling 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FHIT fragile histidine triad
GAMT guanidinoacetate N-methyltransferase
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GPR15 G protein-coupled receptor 15
GRM2 glutamate receptor, metabotropic 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HP haptoglobin
HSPA1L heat shock 70kDa protein 1-like
IL11RA interleukin 11 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
ITGA8 integrin, alpha 8
ITM2C integral membrane protein 2C
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA1107 KIAA1107
KIAA1456 KIAA1456
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MDM4 MDM4, p53 regulator
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NRTN neurturin
NTN1 netrin 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSMR oncostatin M receptor
PDE12 phosphodiesterase 12
PEX5L peroxisomal biogenesis factor 5-like
PHEX phosphate regulating endopeptidase homolog, X-linked
PHOX2A paired-like homeobox 2a
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCD1 phospholipase C, delta 1
PODNL1 podocan-like 1
POF1B premature ovarian failure, 1B
PSAT1 phosphoserine aminotransferase 1
PTPRS protein tyrosine phosphatase, receptor type, S
QPCT glutaminyl-peptide cyclotransferase
RAI2 retinoic acid induced 2
RDH16 retinol dehydrogenase 16 (all-trans)
RHBG Rh family, B glycoprotein (gene/pseudogene)
SDS serine dehydratase
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SLC17A2 solute carrier family 17, member 2
SLC35G2 solute carrier family 35, member G2
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
SP1 Sp1 transcription factor
STAC SH3 and cysteine rich domain
TAC3 tachykinin 3
TMEM206 transmembrane protein 206
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRAIP TRAF interacting protein
TUBA4B tubulin, alpha 4b
TUBB2B tubulin, beta 2B class IIb
TUBB7P tubulin, beta 7, pseudogene
VIPR1 vasoactive intestinal peptide receptor 1
VPREB3 pre-B lymphocyte 3
XYLT1 xylosyltransferase I
ZNF506 zinc finger protein 506
ZNF695 zinc finger protein 695
ZNF701 zinc finger protein 701